Circulating immune complexes of Hodgkin's disease contain an antigen that is present in Hodgkin and reed-sternberg cells

1985 ◽  
Vol 110 (1) ◽  
pp. 56-64 ◽  
Author(s):  
Gerold Bepler ◽  
Qing-yi Zhen ◽  
Klaus Havemann
Keyword(s):  
Immune Complexes ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease ◽  
Circulating Immune Complexes

The in vivo effect of thymic factor (thymostimulin) administration on circulating immune complexes and serum lysozyme levels in untreated Hodgkin's disease patients.

1983 ◽  
Vol 1 (2) ◽  
pp. 117-125 ◽  
Author(s):  
A Velardi ◽  
F Spinozzi ◽  
P Rambotti ◽  
A Tabilio ◽  
A Losito ◽  
...  
Keyword(s):  
Immune Complexes ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease ◽  
Serum Levels ◽  
Mean Value ◽  
Circulating Immune Complexes ◽  
Calf Thymus ◽  
Serum Lysozyme ◽  
Thymic Factor

The in vivo effect of a calf thymus extract, thymostimulin, on the levels of circulating immune complexes (CIC) and serum lysozyme was evaluated in 32 patients with untreated Hodgkin's disease. Using the platelet aggregation test for detecting CICs, 12 patients (37%) had positive titers before thymostimulin treatment; 3 patients (10%) remained positive following therapy. Serum levels of Clq-binding immune complexes were evaluated (greater than 24.5 micrograms/ml) in 8 patients prior to thymostimulin therapy (mean value: 42.3 micrograms/ml); 3 patients continued to have elevated levels after treatment. Serum lysozyme levels for Hodgkin's patients was similar to control values (10.6 vs. 8.3 micrograms/ml); however, the Hodgkin's patients with initially elevated CICs had a lower serum lysozyme level than patients with initially normal CICs (12.9 vs. 7.3, p less than 0.02). Thymostimulin increased serum lysozyme levels in the Hodgkin's patients in whom the CICs were initially elevated (7.3 vs. 10.4 micrograms/ml, p less than 0.05). These data suggest that thymostimulin exerts an effect on the nonspecific immune system of Hodgkin's disease patients.

Circulating immune complexes in Hodgkin's disease

1978 ◽  
Vol 64 (2) ◽  
pp. 289-294 ◽  
Author(s):  
C.Alan Brown ◽  
Clive L. Hall ◽  
John C. Long ◽  
Kathleen Carey ◽  
Sigmund A. Weitzman ◽  
...  
Keyword(s):  
Immune Complexes ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease ◽  
Circulating Immune Complexes

CIRCULATING IMMUNE COMPLEXES AND SYMPTOMS IN HODGKIN'S DISEASE

The Lancet ◽  
1976 ◽  
Vol 307 (7957) ◽  
pp. 449-451 ◽  
Author(s):  
P.L. Amlot ◽  
B.D. Williams ◽  
J.M. Slaney
Keyword(s):  
Immune Complexes ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease ◽  
Circulating Immune Complexes

Correlation between Immune Complexes and Prognostic Factors in Hodgkin's Disease

1978 ◽  
Vol 54 (2) ◽  
pp. 20P-21P
Author(s):  
P. L. Amlot ◽  
B. Pussell ◽  
J. M. Slaney ◽  
B. D. Williams
Keyword(s):  
Prognostic Factors ◽  
Immune Complexes ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease

Precipitable immune complexes in Hodgkin's disease

1983 ◽  
Vol 32 (4) ◽  
pp. 437-441 ◽  
Author(s):  
Hans-Hartwig Euler ◽  
Rosemarie Béress ◽  
Imme Moldenhauer ◽  
Helmut Löffler
Keyword(s):  
Immune Complexes ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease

Binding of Soluble Immune Complexes in Serum of Patients with Hodgkin's Disease to Tissue Cultures Derived from the Tumor

1977 ◽  
Vol 297 (6) ◽  
pp. 295-299 ◽  
Author(s):  
John C. Long ◽  
Clive L. Hall ◽  
C. Alan Brown ◽  
Cathryn Stamatos ◽  
Sigmund A. Weitzman ◽  
...  
Keyword(s):  
Immune Complexes ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease ◽  
Tissue Cultures ◽  
Soluble Immune Complexes

Tonsillectomy: A Prognostic Factor in Hodgkin's Disease?

1981 ◽  
Vol 67 (5) ◽  
pp. 425-430
Author(s):  
Paolo G. Gobbi ◽  
Paola Cavalli ◽  
Bruno Franzini ◽  
Ubaldo Di Prisco ◽  
Massimo Federico ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Immune Complexes ◽  
Hodgkin's Disease ◽  
Lymphoid Tissue ◽  
Prognostic Value ◽  
Hodgkin’S Disease ◽  
Favorable Effect ◽  
Histologic Type ◽  
Survival Curves ◽  
The Past

The clinical features and course of Hodgkin's disease (HD) were investigated in 160 previously tonsillectomized patients and compared with 375 nontonsillectomized ones. In both groups, sex, social class, histologic type, stage and symptoms were almost identically distributed. Tonsillectomized patients showed a higher incidence of initial cervical forms (p < 0.05) and more frequently developed the disease under 35 years of age (p < 0.001), thus also reflecting the different policies of the otolaryngologists in the past few decades. Moreover, the tonsillectomized patients enjoyed a significantly better survival (p ≈ 0.01) than the nontonsillectomized ones. Adjusted survival curves for age and site of initial involvement proved that the favorable prognostic value of tonsillectomy was not due to the altered distribution of these 2 factors in the 2 groups; in addition, an earlier diagnosis in tonsillectomized patients could be excluded. The favorable effect of tonsillectomy in HD patients might be related specifically to the reduced portion of immunologically reacting oropharyngeal lymphoid tissue remaining after tonsillectomy. A decreased output of the specific immune-complexes, which are responsible for the disease, according to Vianna's theory, might be hypothesized in tonsillectomized patients.

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