A preliminary double-blind study on the efficacy of carbamazepine in prophylaxis of manic-depressive illness

1981 ◽  
Vol 73 (1) ◽  
pp. 95-96 ◽  
Author(s):  
Teruo Okuma ◽  
Kazutoyo Inanaga ◽  
Saburo Otsuki ◽  
Keisuke Sarai ◽  
Ryo Takahashi ◽  
...  
Keyword(s):  
Depressive Illness ◽  
Blind Study ◽  
Double Blind Study ◽  
Manic Depressive Illness ◽  
Double Blind ◽  
Manic Depressive

The Nottingham ECT Study

1985 ◽  
Vol 146 (5) ◽  
pp. 520-524 ◽  
Author(s):  
S. Gregory ◽  
C. R. Shawcross ◽  
D. Gill
Keyword(s):  
Clinical Practice ◽  
Depressive Illness ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind ◽  
Highly Effective ◽  
Effective Treatments

SummarySixty nine patients took part in a double-blind study to investigate the efficacy of bilateral, unilateral, and simulated ECT in the treatment of depressive illness. The findings suggest that both bilateral and unilateral ECT are highly effective treatments for depression and are significantly superior to simulated ECT. There was also evidence that patients receiving bilateral ECT recovered more rapidly than those receiving unilateral ECT and required significantly fewer treatments. The relevance of these findings to clinical practice is discussed.

Erythrocyte membrane cation carrier, relapse rate of manic-depressive illness and response to lithium

1976 ◽  
Vol 6 (2) ◽  
pp. 257-263 ◽  
Author(s):  
G. J. Naylor ◽  
D. A. T. Dick ◽  
E. G. Dick
Keyword(s):  
Erythrocyte Membrane ◽  
Affective State ◽  
Sodium Concentration ◽  
Depressive Illness ◽  
Manic Depressive Illness ◽  
Double Blind ◽  
Clinical Events ◽  
Manic Depressive ◽  
Double Blind Clinical Trial ◽  
Before And After

SynopsisBiochemical studies of manic-depressive psychosis usually correlate biochemical findings with current affective state and hence any significant findings could be secondary to mood change. The present study attempts to correlate measures of the erythrocyte membrane cation carrier with clinical events, remote in time from the biochemical assay.Erythrocyte sodium concentration, ouabain-sensitive potassium influx and Na-K ATPase were estimated in 11 patients before and after the cross-over point in a 2-year double blind clinical trial of lithium. Patients with the lowest erythrocyte Na-K ATPase and the highest flux sodium ATPase ratio tended to suffer most episodes of affective illness in the 2 years. Patients who had a low initial Na-K ATPase or a high initial flux sodium ATPase ratio, or in whom this ratio fell most with lithium or whose Na-K ATPase rose most with lithium, clinically responded best to lithium.

Vanadium: a possible aetiological factor in manic depressive illness

1981 ◽  
Vol 11 (2) ◽  
pp. 249-256 ◽  
Author(s):  
Graham J. Naylor ◽  
Anne H. W. Smith
Keyword(s):  
Vitamin C ◽  
Crossover Trial ◽  
Depressive Illness ◽  
Aetiological Factor ◽  
Manic Depressive Illness ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Preliminary Results ◽  
Depressed Patients ◽  
Manic Depressive

SynopsisThe effect of Vitamin C in manic-depressive psychosis was assessed by a double-blind, placebo controlled, crossover trial. Both manic and depressed patients were significantly better following a single 3 g dose of Vitamin C than following a placebo.Preliminary results of a double-blind, crossover comparison of normal vanadium intake with reduced intake in manic and depressed subjects are reported. Both manic and depressed patients were significantly better on reduced intake.These results are in keeping with the suggestion that vanadium may be an aetiological factor in manic depressive illness.

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