Mobile Mental Health for Depression Assistance

Depression is a prevalent and severe medical illness that negatively affects how people feel, think, and act, with estimates pointing towards more than 300 million suffering from depression worldwide. Although effective treatments exist, about 80% of people in low and middle-income countries do not receive therapy. Therefore, technology has become a promising tool to assist in reducing disparities. This study aims to identify and map the available evidence on mobile health applied to depression and clarify key concepts. The authors analyzed clinical trials developed over the last five years. EBSCO and PubMed were searched, and a total of 14 conducted RCTs were selected and reviewed. Despite some limitations regarding dropout rates and several ethical and safety concerns, the mobile mental health future seems promising.

Metabolomics analysis revealed acupuncture treatment target the upstream for dry eye disease

AIM: To find out the pathogenesis of dry eye disease (DED) and the possible mechanisms of available effective treatments. METHODS: A non-targeted technology, ultra-high performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (UHPLC-Q-TOF-MS), to investigate metabolic characterizations for tear samples from 18 patients with DED upon drug or acupuncture treatment. RESULTS: A total of 190 named metabolites were identified, which presented so far the broadest tear metabolome. Further analysis indicated a significantly distinct metabolomics profile among all patients, but very subtle metabolic differences upon drug or acupuncture treatment. On one hand, only six significantly changed metabolites were determined after drug treatment, five of which including inosine, monopalmitin, urate, propionylcarnitine, and nicotinamide were all increased and involved in inflammatory responses. On the other hand, merely four metabolites including alanine, serine, and homoserine were found to be significantly different. Further pathway analysis of those six and four significantly changed metabolites revealed that only one pathway, aminoacyl-tRNA biosynthesis was significantly influenced in acupuncture-treated patients, which were highly associated with the cause of the disease. The results here indicated acupuncture treatment may address the cause rather than the symptoms for dry eye disease, displaying partially better compared with drug treatment. CONCLUSION: Collectively, this work extended our understanding on the key regulatory elements or pathways involved in the potential mechanisms of available effective treatments, and would be useful for providing novel potential targets and therapeutic strategies for DED.

Clinical manifestations, diagnostics and treatment of persistent idiopathic facial pain

Persistent idiopathic facial pain (PIFP) is often regarded as an undiagnosed condition with a poor prognosis. Extensive research on this topic is limited, and there are few effective treatments. Even with an established diagnosis of PIFP, due to poor awareness of the etiology and pathogenesis of the development of the disease, patients struggle with the acceptance of the ‘all-encompassing’ disorder in search of the causes that led to the disease and often undergo unnecessary tests and procedures in search of alternative diagnoses.

Optimizing dosage-specific treatments in a multi-scale model of a tumor growth

The emergence of cell resistance in cancer treatment is a complex phenomenon that emerges from the interplay of processes that occur at different scales. For instance, molecular mechanisms and population-level dynamics such as competition and cell-cell variability have been described as playing a key role in the emergence and evolution of cell resistances. Multi-scale models are a useful tool to study biology at a very different time and spatial scales, as they can integrate different processes that take place at the molecular, cellular and intercellular levels. In the present work, we use an extended hybrid multi-scale model of 3T3 fibroblast spheroid to perform a deep exploration of the parameter space of effective treatment strategies based on TNF pulses. To explore the parameter space of effective treatments in different scenarios and conditions, we have developed an HPC-optimized model exploration workflow based on EMEWS. We first studied the effect of the cells spatial distribution in the values of the treatment parameters by optimizing the supply strategies in 2D monolayers and 3D spheroids of different sizes. We later study the robustness of the effective treatments when heterogeneous populations of cells are considered. We found that our model exploration workflow can find effective treatments in all the studied conditions. Our results show that cells' spatial geometry, as well as, population variability should be considered when optimizing treatment strategies in order to find robust parameter sets.

Psychoneurobiology Research and Personalized Treatment of Schizophrenia

Psychoneurobiological approaches have been used to develop effective treatments for unmet needs in schizophrenia, e [...]

COVID cure or perpetual vaccination?: 30 cheap effective treatments of COVID-19 & variants, like ivermectin, or never-ending compulsory injection, with unsafe, genotoxic, infertilizing, injuring, crippling, handicapping, lethal, inefficient, ineffective, abortion-tainted, abortive, unethical, experimental genetic-hacks, deceivingly called vaccines instead of haccines? Scientific proof of the COVID PLANdemic with 1000 peer reviewed published references.

What is 10x more lethal than COVID-19? Viral covidiocy. 9 out of 10 COVID deaths were vaccinated in Argentina, where case fatality rate was 1300% higher for the vaccinated than for the unvaccinated, plus a higher 40% contagion rate (5% if unvaccinated): the opposite of the narrative. Though not as drastic, Israel, UK, Chile, Uruguay and the USA, also showed worse outcomes for the vaccinated than the unvaxxed, because of different natural evolution of variant waves, periods, treatments and vaccine brands. COVID waves seem to have receded due to the increase of herd immunity of the recovered, both vaccinated and unvaccinated.In the USA and Europe, 5 million adverse reactions and 70 thousand deaths were reported linked to COVID vaccines. Informed consent forms can’t protect COVID-19 vaccine manufacturers against legal actions, even under immunity by law, not only because they are not really “vaccines” but gene hacks to produce the S1 spike protein (or parts), nor because some or all the elements are secret, un-disclosed or hidden, but especially, because the cure had been found, voiding Emergency Use Authorization (EUA): if you get COVID, especially if vaccinated, follow this successful evidence-based treatment: https://covid19criticalcare.com/covid-19-protocols/ ( translations: https://covid19criticalcare.com/covid-19-protocols/translations/ ). Yet, there are many other options in this document.This research is not “anti-vaccine”, but pro-sane-vaccines. Unlike insane vaccines, it stands for evidence based medicine, i.e. scientifically proven safe and effective treatments. 500 scientific citations prove a systemic bias against cheap effective cures and towards unethical, ineffective and/or unsafe vaccines.Among dozens of effective treatments here reviewed, ivermectin is the best mass cure for COVID-19 variants. It had been scientifically proven beyond any reasonable doubt by May 2020, yet, instead of informing the public about the amazing results and going back to normal, there was a global scheme to block lifesaving information and promote lock downs, masks, restrictions, experimental vaccines and passports.1 million dollars of ivermectin would end the pandemic compared to 160 thousand million dollars PER YEAR to keep a perpetual endemic disease, with vaccines always chasing new variants in a never ending lucrative arms race. It is not a matter of unsettled science: there are more RCT studies than for any other standard-of-care treatment. An insane “war on bugs” by legal drug cartels?With COVID vaccines, Governments have turned a medical act into an administrative mandate. Yet, not a single medical association protested against this violation of the right of the physician to practice medicine, i.e. a customized treatment according to the best knowledge/possibilities?Human rights continue to be systematically violated: to life, to informed consent, to fertility, to ethical treatments (where benefits are higher than harms), to healthcare (instead of sickening-care), to treatments for vaccine injuries, to compensation for injuries and death, to privacy (passes), to freedom (to work, move, assemble, worship), etc.This research presents scientific evidence for a planned global genocide: COVID lab creation, vital information cover-up, deadly recommendations, COVID cure censorship and lethal disinformation to promote dangerous vaccines, which are the worst medical and epidemiological solution to the plandemic:MAY A PERSON :WITHCOVIDVACCINATIONWITHEFFECTIVETREATMENTAVOID GETTING SICK FROM COVID?🗴 No✓ YesAVOID INFECTING OTHERS?🗴 No✓ YesAVOID HOSPITALIZATION?🗴 No✓ YesAVOID DYING FROM COVID?🗴 No✓ YesAVOID SIDE-EFFECTS LIKE INFERTILITY, MISCARRIAGE, DISABILITY OR DEATH?🗴 No✓ YesGET HEALTHCARE OR MANUFACTURER LIABILITY FOR INJURIES, DEATH OR NEGLIGENCE?🗴 No✓ YesHELP PROTECT OTHERS?🗴 No✓ YesHELP REDUCE THE SATURATION OF THE HEALTH SYSTEM?🗴 No✓ YesGENERATE HERD IMMUNITY?🗴 No✓ YesHELP TO END THE PANDEMIC?🗴 No✓ YesREDUCE THE GENERATION AND SPREAD OF VARIANTS?🗴 No✓ YesAVOID COOPERATION WITH VACCINES PRODUCED WITH ABORTION CELL LINES?🗴 No✓ YesGIVE INFORMED CONSENT WITH A PACKAGE INSERT LISTING ALL THE INGREDIENTS?🗴 No✓ YesAVOID UNDISCLOSED GENE-HACKING, NANO-TAMPERING AND BLUETOOTH CHIP?🗴 No✓ YesFrom the systematic genocide of abortion, they moved on to the COVID genocide of the elderly blocking effective treatment, and then, to the mass genocide with experimental vaccines, starting with the elderly and ending with the babies, even the unborn (vaccinating the pregnants). The genocidal trend didn’t change, only the target population. Same serial killers, different weapons.Hosea 4:6 “My people are dying for lack of knowledge...”

The Role of Pathogens and Anti-Infective Agents in Parkinson’s Disease, from Etiology to Therapeutic Implications

Parkinson’s disease is a debilitating neurodegenerative disorder whose etiology is still unclear, hampering the development of effective treatments. There is an urgent need to identify the etiology and provide further effective treatments. Recently, accumulating evidence has indicated that infection may play a role in the etiology of Parkinson’s disease. The infective pathogens may act as a trigger for Parkinson’s disease, the most common of which are hepatitis C virus, influenza virus, and Helicobacter pylori. In addition, gut microbiota is increasingly recognized to influence brain function through the gut-brain axis, showing an important role in the pathogenesis of Parkinson’s disease. Furthermore, a series of anti-infective agents exhibit surprising neuroprotective effects via various mechanisms, such as interfering with α-synuclein aggregation, inhibiting neuroinflammation, attenuating oxidative stress, and preventing from cell death, independent of their antimicrobial effects. The pleiotropic agents affect important events in the pathogenesis of Parkinson’s disease. Moreover, most of them are less toxic, clinically safe and have good blood-brain penetrability, making them hopeful candidates for the treatment of Parkinson’s disease. However, the use of antibiotics and subsequent gut dysbiosis may also play a role in Parkinson’s disease, making the long-term effects of anti-infective drugs worthy of further consideration and exploration. This review summarizes the current evidence for the association between infective pathogens and Parkinson’s disease and subsequently explores the application prospects of anti-infective drugs in Parkinson’s disease treatment, providing novel insights into the pathogenesis and treatment of Parkinson’s disease.