Oestrogen treatment of constitutionally tall girls with 0.1 mg/day ethinyl oestradiol

1988 ◽  
Vol 147 (1) ◽  
pp. 59-63 ◽  
Author(s):  
O. Bartsch ◽  
B. Weschke ◽  
B. Weber
Keyword(s):  
Oestrogen Treatment ◽  
Tall Girls ◽  
Ethinyl Oestradiol

Oestrogen treatment of adolescent tall girls; short term side effects

1986 ◽  
Vol 113 (4_Suppl) ◽  
pp. S170-S173 ◽  
Author(s):  
OLAV TRYGSTAD
Keyword(s):  
Side Effects ◽  
Idiopathic Scoliosis ◽  
Final Height ◽  
Psychosocial Problems ◽  
Short Term ◽  
Oestrogen Treatment ◽  
Duration Of Therapy ◽  
Tall Girls ◽  
The Mean ◽  
Ethinyl Oestradiol

Abstract In 1980-1985 680 preadolescent tall girls were treated with pharmacological doses of oestrogen to reduce final height. Indications for the therapy were predicted final height >+2.5 SD (180.75 cm), idiopathic scoliosis, and psychosocial problems. Until 1976 141 girls were given diethyl stilboestrol 5 mg daily. By advice of Prader this was then replaced by ethinyl oestradiol and a progestin was given on days 5-10 each month. The mean duration of therapy was close to 2 years. The observed short-term unwanted effects were due to the pharmacological actions of the drugs, (11 girls had galactorrhoea at the end of therapy; no pituitary prolactionoma was observed) or events happening by chance.

Oestrogen treatment to reduce the adult height of tall girls: long-term effects on fertility

The Lancet ◽  
2004 ◽  
Vol 364 (9444) ◽  
pp. 1513-1518 ◽  
Author(s):  
Alison Venn ◽  
Fiona Bruinsma ◽  
George Werther ◽  
Priscilla Pyett ◽  
Donna Baird ◽  
...  
Keyword(s):  
Adult Height ◽  
Long Term Effects ◽  
Oestrogen Treatment ◽  
Tall Girls

Differential effects of oestrogen treatment on the proportionality of growth in tall girls

1989 ◽  
Vol 149 (1) ◽  
pp. 14-17 ◽  
Author(s):  
M. Hermanussen ◽  
K. Geiger-Benoit ◽  
J. Burmeister
Keyword(s):  
Oestrogen Treatment ◽  
Differential Effects ◽  
Tall Girls

Impact of different doses of ethinyl oestradiol on reduction of final height in constitutionally tall girls

1994 ◽  
Vol 153 (11) ◽  
pp. 797-801 ◽  
Author(s):  
E. E. Joss ◽  
J. Zeuner ◽  
R. P. Zurbrügg ◽  
P. E. Mullis
Keyword(s):  
Final Height ◽  
Tall Girls ◽  
Different Doses ◽  
Ethinyl Oestradiol

The effect of oestrogen treatment on body proportions in constitutionally tall girls

1994 ◽  
Vol 153 (4) ◽  
pp. 237-240 ◽  
Author(s):  
J. M. Brinkers ◽  
P. J. Lamoré ◽  
E. F. Gevers ◽  
B. Boersma ◽  
J. M. Wit
Keyword(s):  
Body Proportions ◽  
Oestrogen Treatment ◽  
Tall Girls

On the ethics of oestrogen treatment for tall girls: an update

2009 ◽  
Vol 35 (11) ◽  
pp. 713-714 ◽  
Author(s):  
P Louhiala
Keyword(s):  
Oestrogen Treatment ◽  
Tall Girls

PROTEIN C AND PROTEIN S LEVELS IN TALL GIRLS TREATED WITH ETHINYL -OESTRADIOL

1987 ◽  
Author(s):  
I A Huisveld ◽  
E C G Greven ◽  
B N Bouma
Keyword(s):  
Protein C ◽  
Binding Protein ◽  
Protein S ◽  
Slight Reduction ◽  
Selective Precipitation ◽  
Factor Ii ◽  
Tall Girls ◽  
High Doses ◽  
Ethinyl Oestradiol

Increased levels of several coagulation factors and reduced levels of anti thrombin III (ATIII) have been observed in adults on oestrogen medication and in girls who were treated for excessive tallness with high doses of ethinyloestradiol (E2). In females using oral contraceptives an additional effect on the protein C system has been reported. In our study we evaluated the effect of e-thinyloestradiol treatment (0.1-0.3 mg, administered for at least 6 months) in 14 tall girls (age 14 + 2 yr and height 179 + 4 cm). 13 girls of comparable age (13 + 2 yr) and height 175 + 7 cm) served as controls. Protein C, protein S, C4-binding protein as well as Factor II, plasminogen and ATIII antigen levels were determined by rocket immunoelectrophoresis. ATI11 heparin cofactor ami do-lytic activity was assessed using S2222. Protein S antigen not in complex with C4b-binding protein (PSfree), was assayed in the supernatant plasma after selective precipitation of the protein S-C4b-binding protein complex with PEG 8000. Complete separation of free protein S and PS-C4b-bp complex was verified with crossed immunoelectrophoresis. Results were expressed as % of a normal pool. In the group of girls who were being treated with ethinyl oestradiol (E2-users) significantly higher levels (P<0.001) were observed for protein C (126 ± 29 vs 88 ± 10 in the controls), Factor II (109 ± 18 vs 81 ± 12 in the controls) and plasminogen (131 ± 19 vs 85 ± 9 in the controls). Protein S (58 ± 10 vs 97 ± 8 in the controls) and PSfree (54 ± 11 vs 88 ± 11 in the controls) were sig nificantly reduced (P<0.001) in the E2-users. Only a slight reduction was observed in ATIII antigen levels (95 ± 16 vs 104 ± 9 in the controls) and in the ATIII heparin cofactor activity (105 ± 14 vs 104 ± 9 in the controls). No difference between E2-users and controls was observed in the C4b-binding protein levels (111 ± 25 vs 114 ± 33).Results indicate that treatment of tall girls with high doses of synthetic oestrogens is associated with in vitro signs of hypercoagulability quite comparable to those observed in adult females. However, in contrast to observations made in adults no thromboembolic complications have been reported in juvenile subjects on E2-medication implying additional (aqe-related) variables in the qe-nesis of thrombosis.

Studies of the factors modulating antidiuretic hormone excretion in man in response to the osmolar stimulus: effects of oestrogen and angiotensin II

1983 ◽  
Vol 104 (3) ◽  
pp. 295-302 ◽  
Author(s):  
Michel B. Vallotton ◽  
Ulrich Merkelbach ◽  
Rolf C. Gaillard
Keyword(s):  
Angiotensin Ii ◽  
Antidiuretic Hormone ◽  
Hypertonic Saline ◽  
Plasma Renin ◽  
Electrolyte Balance ◽  
Renin Substrate ◽  
Oestrogen Treatment ◽  
Significant Difference ◽  
The Mean ◽  
Ethinyl Oestradiol

Abstract. The aim of this study was to assess the influence of hormones known to regulate fluid and electrolyte balance on the release of antidiuretic hormone induced by raising serum osmolality. The stimulus provoked by the infusion of a 2.5% NaCl solution induces an increase of urinary [arginine-8]vasopressin from 1.12 to 2.64 ng/h in men and from 1.65 to 7.27 ng/h in women as has been previously reported. These results were compared to those obtained in males infused with angiotensin II (All) before and during a hypertonic sodium load and in males infused with hypertonic saline on the fourth day of administration of ethinyl-oestradiol. During the combined infusion of All and then hypertonic saline, the mean hourly urinary excretion of AVP increased from 2.8 to 5.67 ng/h. Within each group the increase of urinary AVP was highly significant. The rise of urinary AVP during All infusion was significantly different from the rise observed both in untreated males and untreated females, lying in between. The mean hourly excretion rate of AVP increased before and after hypertonic saline loading from 2.65 to 5.3 ng/h in males pre-treated with ethinyl-oestradiol. The significant difference observed between males and females is reduced when males treated with oestrogen were compared to female subjects. In each group plasma renin activity decreased to low values during the salt-loading test. During oestrogen treatment PRA and plasma renin substrate rose, while urinary aldosterone remained almost unchanged. We conclude that All stimulates the release of AVP in males and potentiates the response of AVP to the osmolar stimulus, and that oestrogen potentiates in man the release of AVP in response to the osmolar stimulus. This oestrogenic effect may account for the observed sex difference.

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