Indomethacin and cerebral blood flow in premature infants treated for patent ductus arteriosus

1988 ◽  
Vol 147 (3) ◽  
pp. 315-316 ◽  
Author(s):  
O. Pryds ◽  
G. Greisen ◽  
K. H. Johansen
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Patent Ductus Arteriosus ◽  
Premature Infants ◽  
Ductus Arteriosus ◽  
Patent Ductus

Cerebral Blood Flow Velocity During Occlusive Manipulation of Patent Ductus Arteriosus in Children

1999 ◽  
Vol 9 (1) ◽  
pp. 23-29 ◽  
Author(s):  
Rosendo A Rodriguez ◽  
Garry Cornel ◽  
Martin C Hosking ◽  
Nihal Weerasena ◽  
William M Splinter ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Patent Ductus Arteriosus ◽  
Flow Velocity ◽  
Blood Flow Velocity ◽  
Cerebral Blood Flow Velocity ◽  
Ductus Arteriosus ◽  
Patent Ductus

scholarly journals 124 PATENT DUCTUS ARTERIOSUS AND CEREBRAL BLOOD FLOW

1986 ◽  
Vol 20 (10) ◽  
pp. 1054-1054 ◽  
Author(s):  
E Saliba ◽  
A Chantepie ◽  
M C Vaillant ◽  
D Bloc ◽  
L Pourcelot ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Patent Ductus Arteriosus ◽  
Ductus Arteriosus ◽  
Patent Ductus

Abnormal cerebral blood flow patterns in preterm infants with a large patent ductus arteriosus

1982 ◽  
Vol 101 (4) ◽  
pp. 587-593 ◽  
Author(s):  
Richard E. Behrman ◽  
Christopher G. Martin ◽  
A. Rebecca Snider ◽  
Steven M. Katz ◽  
Joyce L. Peabody ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Patent Ductus Arteriosus ◽  
Preterm Infants ◽  
Ductus Arteriosus ◽  
Flow Patterns ◽  
Blood Flow Patterns ◽  
Patent Ductus

scholarly journals Prediction of early diagnosis of acute kidney injury in premature infants with hemodynamically significant patent ductus arteriosus

2020 ◽  
pp. 5-11
Author(s):  
T.P. Borysova ◽  
◽  
O.U. Obolonska ◽  
O.E. Khudyakov ◽  
◽  
...  
Keyword(s):  
Blood Flow ◽  
Patent Ductus Arteriosus ◽  
Serum Creatinine ◽  
Renal Artery ◽  
Flow Velocity ◽  
Premature Infants ◽  
Blood Flow Velocity ◽  
Ductus Arteriosus ◽  
Kidney Injury ◽  
Patent Ductus

The development of acute kidney injury (AKI) in preterm infants with hemodynamically significant patent ductus arteriosus (HSPDA) is an additional burden on homeostatic mechanisms, leading to loss of fluid, electrolyte balance, and acid-base disturbance and increasing the risk of mortality by 50%. Therefore, early detection of AKI in preterm infants with HSPDA is extremely important in terms of improving treatment outcomes. Purpose — to create, evaluate and further analyze the binary logistic regression model of AKI on the background of HSPDA in premature infants. Materials and methods. The group of study participants consisted of 40 premature babies with HSPDA, who were admitted for treatment on the first day of life to the Department of Anesthesiology and Neonatal Intensive Care at MI «Dnepropetrovsk Regional Children's Clinical Hospital» Dnepropetrovsk Regional Council». On the third to fifth day of life, 23 (57.5%) patients were diagnosed with AKI. Clinical and laboratory examination included obstetric history, gestational age, weight, physical examination, clinical analysis of blood and urine, arterial blood oxygen saturation, biochemical methods — examination of urea, serum and urine creatinine, serum and urine sodium, serum potassium. The concentration index of creatinine, fractional excretion of sodium, glomerular filtration rate (GFR) according to the Schwartz formula were calculated. Instrumental methods of examination included echocardiography with Doppler, ultrasound Doppler of renal vessels, renal spectroscopy in the near infrared region. In order to preliminarily determine the diagnostic potential of some clinical'anamnestic and laboratory data, the parameters of the sample with AKI and the sample without this pathology were compared: in the case of interval scale the Mann–Whitney U-test was used, in the case of categorical scale — χ2-test or Fisher's exact test. Spearman's rank correlation was used to form the optimal set of input variables for regression modeling. The method of binary logistic regression was used to develop a diagnostic model of AKI development on the background of HSPDA in premature infants. Results. At the stage of exploratory data analysis (several dozen parameters of clinical and biochemical analysis of blood and urine, renal hemodynamics, renal oxygenation and therapeutic measures on the first day), as well as clinical and anamnestic data, it was found that AKI has a significant relationship with 14 interval ( maximum blood flow velocity in the interlobar renal artery, minimum blood flow velocity in the interlobar renal artery, resistance index in the interlobar renal artery, maximum blood flow velocity in the main renal artery, diameter of the open arterial duct, renal oxygenation, fractional renal tissue extraction of oxygen, serum creatinine, GFR, creatinine concentration index, urinary sodium, fractional sodium excretion, urine protein, diastolic blood pressure) and 9 nominal values (the size of the patent ductus arteriosus on the first day of more than 2 mm, ibuprofen therapy at a dose of 20 mg/kg on the first day, ibuprofen therapy on the first day of life, furosemide treatment, history of renal disease in the mother, chronic foci of infection in the mother, hypertension of pregnancy, threat of abortion, necrotizing enterocolitis in the patient on the first day of life). Conclusions. The most significant predictors of AKI development in premature infants with HSPDA are the parameter of maximum blood flow velocity in the interlobar renal artery, HSPDA diameter greater than 2 mm and serum creatinine level on the first day of life. The sensitivity of the AKI logistic regression model, in which HSPDA diameter and serum creatinine level are used as explanatory variables, is 91%, specificity — 88%, overall accuracy — 90%. Replacement of serum creatinine in the logit function for the maximum blood flow velocity in the interlobar renal artery allows to increase the sensitivity of the model up to 96%, and the overall accuracy up to 93%. The study was conducted in accordance with the principles of the Helsinki Declaration. The research protocol was approved by the Local Ethics Committee of the institution mentioned in the work. Informed consent of parents of children was obtained for the research. The authors were declare no conflict of interest. Key words: hemodynamically significant patent ductus arteriosus, premature infants, acute kidney injury, prediction of early diagnosis.

Cerebral Blood Flow

PEDIATRICS ◽  
1982 ◽  
Vol 70 (6) ◽  
pp. 1013-1013
Author(s):  
BARRY G. BAYLEN ◽  
GEORGE C. EMMANOUILIDES
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Patent Ductus Arteriosus ◽  
Brain Damage ◽  
Pulsatility Index ◽  
Ductus Arteriosus ◽  
Before And After ◽  
The Brain ◽  
Patent Ductus

In the commentary, "Pulsatility Index, Patent Ductus Arteriosus, and Brain Damage," It was stated that we have shown that "blood flow" to the brain was not reduced in premature lambs with left-right ductal shunting. The abstracted data referred primarily to alteration of the percent distribution of blood flow and not to changes of absolute blood flow to systemic organs before and after patent ductus arteriosus (PDA) occlusion in preterm lambs. We subsequently demonstrated that absolute cerebral blood flow (milliliters per gram per minute) in fact was significantly reduced in preterm lambs with PDA.

scholarly journals The effect of patent ductus arteriosus on coronary artery blood flow in premature infants: a prospective observational pilot study

2020 ◽  
Vol 40 (9) ◽  
pp. 1366-1374 ◽  
Author(s):  
Yulia Vaisbourd ◽  
Dawod Sharif ◽  
Arieh Riskin ◽  
Liat Yaniv ◽  
Gil Dinur ◽  
...  
Keyword(s):  
Blood Flow ◽  
Coronary Artery ◽  
Pilot Study ◽  
Patent Ductus Arteriosus ◽  
Premature Infants ◽  
Ductus Arteriosus ◽  
Artery Blood Flow ◽  
Patent Ductus

scholarly journals State of Renal Blood Flow in Premature Children with Hemodynamically Significant Patent Ductus Arteriosus

2021 ◽  
Vol 2 ◽  
pp. 6-13
Author(s):  
Tamara Borysova ◽  
Olga Obolonska ◽  
Irina Andreychenko
Keyword(s):  
Blood Flow ◽  
Patent Ductus Arteriosus ◽  
Renal Artery ◽  
Renal Blood Flow ◽  
Premature Infants ◽  
Ductus Arteriosus ◽  
Peak Systolic Velocity ◽  
Renal Arteries ◽  
Main Renal Artery ◽  
Patent Ductus

Abstract: Introduction: Hemodynamically significant patent ductus arteriosus (HSPDA) lowers the renal circulation because of the "ductal stealing phenomenon," which can change the renal blood flow. The aim: To study the state of blood flow in the main renal artery and interlobar renal artery in premature infants with HSPDA.  Materials and methods: 74 preterm newborns (gestational age 29-36 weeks) were divided into three groups: І - 40 children with HSPDA, ІІ - 17 children with patent ductus arteriosus (PDA) without hemodynamic disorders, ІІІ - 17 children with closed ductus arteriosus. Color ultrasound Doppler scan of the vascular bed of the kidneys was performed using a microconvex sensor with a frequency of 5-8 MHz ("TOSHIBA" Nemso XG model SSA-580A (Japan) from the main renal artery to the interlobar renal arteries of the right kidney. The following parameters of renal blood flow were studied: peak systolic velocity (PSV), end-diastolic velocity (EDV), resistance index (RI).  Results: Peak systolic velocity (PSV) in the main renal artery and interlobar renal arteries did not differ significantly between groups. On the first, third, and tenth days of life, there was a significant decrease in the EDV of blood flow and increased RI in the main renal artery. The EDV of blood flow and RI in the interlobar renal artery on the first day of life did not differ depending on PDA's presence and its hemodynamic significance. On the third and tenth days of life and in the interlobar renal artery, a significant decrease in EDV of blood flow and increased RI were noted. These renal blood flow characteristics were closely related to the size of the PDA on the first day of life. Conclusion: A feature of renal hemodynamics in HSPDA in premature infants is a decrease in the EDV of blood flow in the main renal artery and interlobar renal artery, as well as an increase in the RI of these vessels, directly correlating with the size of the PDA in the first day of life. During the first ten days of life, dynamic control revealed a slowed process of restoration of renal blood flow in babies with HSPDA, despite the PDA's closure.

Sign in / Sign up

Export Citation Format

Share Document