The supernormal period of the cerebellar parallel fibers effects of [Ca2+]o and [K+]o

1983 ◽  
Vol 397 (3) ◽  
pp. 176-183 ◽  
Author(s):  
Robert C. Malenka ◽  
Jeffery D. Kocsis ◽  
Stephen G. Waxman

Author(s):  
Mario Spagnuolo ◽  
Antonio M. Cazzani

AbstractIn this work, an extension of the strain energy for fibrous metamaterials composed of two families of parallel fibers lying on parallel planes and joined by connective elements is proposed. The suggested extension concerns the possibility that the constituent fibers come into contact and eventually scroll one with respect to the other with consequent dissipation due to friction. The fibers interact with each other in at least three different ways: indirectly, through microstructural connections that could allow a relative sliding between the two families of fibers; directly, as the fibers of a family can touch each other and can scroll introducing dissipation. From a mathematical point of view, these effects are modeled first by introducing two placement fields for the two fiber families and adding a coupling term to the strain energy and secondly by adding two other terms that take into account the interdistance between the parallel fibers and the Rayleigh dissipation potential (to account for friction).



2016 ◽  
Vol 41 (5) ◽  
pp. E149-E158 ◽  
Author(s):  
VF Wandscher ◽  
CD Bergoli ◽  
IF Limberger ◽  
TP Cenci ◽  
P Baldissara ◽  
...  

SUMMARY Objective: This article aims to present a fractographic analysis of an anterior tooth restored with a glass fiber post with parallel fiber arrangement, taking into account force vectors, finite element analysis, and scanning electron microscopy (SEM). Methods: A patient presented at the Faculty of Dentistry (Federal University of Santa Maria, Brazil) with an endodontically treated tooth (ETT), a lateral incisor that had a restorable fracture. The treatment was performed, and the fractured piece was analyzed using stereomicroscopy, SEM, and finite element analysis. Results: The absence of remaining coronal tooth structure might have been the main factor for the clinical failure. We observed different stresses actuating in an ETT restored with a fiber post as well as their relationship with the ultimate fracture. Tensile, compression, and shear stresses presented at different levels inside the restored tooth. Tensile and compressive stresses acted together and were at a maximum in the outer portions and a minimum in the inner portions. In contrast, shear stresses acted concomitantly with tensile and compressive stresses. Shear was higher in the inner portions (center of the post), and lower in the outer portions. This was confirmed by finite element analysis. The SEM analysis showed tensile and compression areas in the fiber post (exposed fibers=tensile areas=lingual surface; nonexposed fibers=compression areas=buccal surface) and shear areas inside the post (scallops and hackle lines). Stereomicroscopic analysis showed brown stains in the crown/root interface, indicating the presence of microleakage (tensile area=lingual surface). Conclusion: We concluded that glass fiber posts with parallel fibers (0°), when restoring anterior teeth, present a greater fracture potential by shear stress because parallel fibers are not mechanically resistant to support oblique occlusal loads. Factors such as the presence of remaining coronal tooth structure and occlusal stability assist in the biomechanical equilibrium of stresses that act upon anterior teeth.





1996 ◽  
Vol 10 (1) ◽  
pp. 192-192
Author(s):  
Siu-Chun Lee ◽  
Jan A. Grzesik


1985 ◽  
Vol 54 (5) ◽  
pp. 1346-1362 ◽  
Author(s):  
H. A. Swadlow

The long-term stability of conduction velocity and recovery processes were studied in a fast-conducting (corticotectal) and in a more slowly conducting (visual callosal) axonal system. Chronic microelectrode recording methods were used in conjunction with antidromic activation via electrical stimulation at one or more axonal site. These methods enabled 54 axons to be studied for greater than 20 days and seven of these cells to be studied for 101-448 days. The conduction velocities of corticotectal axons were characteristic of myelinated axons and were very stable over time. The conduction velocities of most callosal axons were characteristic of nonmyelinated axons, and 68% of callosal axons had conduction velocities that were stable over long periods of time. Of the remaining callosal axons, approximately one third showed an increase in conduction velocity (8-14%), whereas two thirds showed a progressive and systematic decrease in conduction velocity (6-81%). These changes in conduction velocity were distributed along the callosal axon, rather than limited to a single segment of axon. Although the refractory period of callosal and corticotectal axons showed considerable variability over time, the minimal interval between two conducted impulses was stable. The stability of this property was remarkable because the minimal interspike intervals of different axons with similar conduction velocities often differed greatly. Callosal axons show a supernormal period of increased conduction velocity following the relative refractory period and a subsequent subnormal period of decreased conduction velocity following a burst of prior impulses. In different callosal axons the magnitude of the velocity changes (percent change) differs greatly, even among axons of the same conduction velocity. For a given axon, however, these properties are very stable over time. These results on axonal properties may be useful in studies requiring the examination of extracellular responses of individual neurons over long periods of time. Antidromic latency provides a useful means of identifying a cell, particularly when conduction times are long. The stability of the minimal interspike interval and the supernormal period within individual axons make them suitable as ancillary criteria in identifying individual neurons. These three measures are independent of spike amplitude and waveform, and together they provide a "signature" by which individual cortical neurons can be identified over periods that represent a significant portion of the lifespan of adult mammals.



2019 ◽  
Vol 98 (12) ◽  
pp. 1287-1293 ◽  
Author(s):  
N.P. Lang

The discovery of the phenomenon “osseointegration,” or functional ankylosis, has led to the development of oral implants with high clinical performance. Consequently, the placement of titanium implants has changed the paradigms of restorative dentistry. Implants are used to prevent placing reconstructions anchored on natural teeth when these are vital and intact. Furthermore, implants are suitable to improve subjective chewing function and to replace missing and strategically important abutments. The osseointegration process is characterized by a predictable sequence of healing events that encompass the formation of woven bone, parallel fibers, and lamellar bone and result in fully functional bone that will remodel throughout life. While the osseointegration facilitates the use of implants as prosthetic abutments, it has to be kept in mind that the peri-implant soft tissue may be subject to biological complications. This, in turn, may result in an infectious process that will jeopardize the osseointegration. Consequently, the monitoring of the peri-implant tissues is an important aspect, and early intervention in situations with peri-implant mucositis is mandatory for the prevention of peri-implantitis. Hence, it is evident that oral implants need lifelong maintenance care if their longevity is to be assured.



2010 ◽  
Vol 68 ◽  
pp. e335
Author(s):  
Aya Ito-Ishida ◽  
Eriko Miura ◽  
Keiko Matsuda ◽  
Michisuke Yuzaki ◽  
Shigeo Okabe


2010 ◽  
Vol 104 (5) ◽  
pp. 2462-2473 ◽  
Author(s):  
Michael T. Roberts ◽  
Laurence O. Trussell

In the outer layers of the dorsal cochlear nucleus, a cerebellum-like structure in the auditory brain stem, multimodal sensory inputs drive parallel fibers to excite both principal (fusiform) cells and inhibitory cartwheel cells. Cartwheel cells, in turn, inhibit fusiform cells and other cartwheel cells. At the microcircuit level, it is unknown how these circuit components interact to modulate the activity of fusiform cells and thereby shape the processing of auditory information. Using a variety of approaches in mouse brain stem slices, we investigated the synaptic connectivity and synaptic strength among parallel fibers, cartwheel cells, and fusiform cells. In paired recordings of spontaneous and evoked activity, we found little overlap in parallel fiber input to neighboring neurons, and activation of multiple parallel fibers was required to evoke or alter action potential firing in cartwheel and fusiform cells. Thus neighboring neurons likely respond best to distinct subsets of sensory inputs. In contrast, there was significant overlap in inhibitory input to neighboring neurons. In recordings from synaptically coupled pairs, cartwheel cells had a high probability of synapsing onto nearby fusiform cells or other nearby cartwheel cells. Moreover, single cartwheel cells strongly inhibited spontaneous firing in single fusiform cells. These synaptic relationships suggest that the set of parallel fibers activated by a particular sensory stimulus determines whether cartwheel cells provide feedforward or lateral inhibition to their postsynaptic targets.



1938 ◽  
Vol 124 (3) ◽  
pp. 591-595 ◽  
Author(s):  
H. E. Hoff ◽  
L. H. Nahum


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