Identity of inhibitory presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT1B binding sites

1986 ◽  
Vol 332 (1) ◽  
pp. 1-7 ◽  
Author(s):  
G. Engel ◽  
M. G�thert ◽  
D. Hoyer ◽  
E. Schlicker ◽  
K. Hillenbrand
Keyword(s):  
Rat Brain ◽  
Binding Sites ◽  
Brain Cortex ◽  
Rat Brain Cortex

Characterization of [3H]-forskolin binding sites in young and adult rat brain cortex: identification of suramin as a competitive inhibitor of [3H]-forskolin binding

2005 ◽  
Vol 83 (7) ◽  
pp. 573-581 ◽  
Author(s):  
Jiri Stöhr ◽  
Jiri Novotny ◽  
Petr Svoboda
Keyword(s):  
Rat Brain ◽  
Binding Sites ◽  
Brain Cortex ◽  
Specific Binding ◽  
Age Groups ◽  
Competitive Inhibitor ◽  
Adenyl Cyclase Activity ◽  
High Affinity ◽  
Young Rats ◽  
Rat Brain Cortex

Little is know about forskolin binding in the rat brain during ontogenetic development. For this paper, we have characterized specific binding sites for [3H]-forskolin in cerebrocortical membranes from young (12-day-old) and adult (90-day-old) rats. High-affinity, as well as super-high-affinity, [3H]-forskolin binding sites were detected in samples from both age groups tested, and the binding parameters of these sites differed significantly. Whereas the number of high-affinity [3H]-forskolin binding sites was higher by about 50% in adult than in young rats, their affinity was markedly (about 4 times) lower. In the presence of AlF4–, the number high-affinity [3H]-forskolin binding sites in samples from young rats rose to the level determined in samples from adult animals, and the number of super-high-affinity sites considerably increased in both age groups. The different characteristics of [3H]-forskolin binding found in cerebrocortical membranes from young and adult rats may be closely related to markedly diminished adenyl cyclase activity in preparations from adult animals. Results of our experiments with suramin indicated that this drug may act as a competitive inhibitor of [3H]-forskolin binding. Key words: rat brain cortex; development; forskolin binding; suramin.

Effects of anesthetics on sodium uptake into rat brain cortex in vitro

1972 ◽  
Vol 21 (12) ◽  
pp. 1763-1773 ◽  
Author(s):  
R. Shankaran ◽  
J.H. Quastel
Keyword(s):  
Rat Brain ◽  
Brain Cortex ◽  
Sodium Uptake ◽  
Rat Brain Cortex

The expression changes of Numblike in rat brain cortex after traumatic brain injury

2012 ◽  
Vol 43 (2) ◽  
pp. 195-201 ◽  
Author(s):  
Shengyang Jiang ◽  
Xiaohong Wu ◽  
Yaohua Yan ◽  
Jian Xu ◽  
Bai Shao ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Rat Brain ◽  
Brain Cortex ◽  
Rat Brain Cortex

Aluminum accumulation and membrane fluidity alteration in synaptosomes isolated from rat brain cortex following aluminum ingestion: effect of cholesterol

2002 ◽  
Vol 44 (2) ◽  
pp. 181-193 ◽  
Author(s):  
Virgı́lia S Silva ◽  
J Miguel Cordeiro ◽  
Manuel J Matos ◽  
Catarina R Oliveira ◽  
Paula P Gonçalves
Keyword(s):  
Rat Brain ◽  
Membrane Fluidity ◽  
Brain Cortex ◽  
Rat Brain Cortex ◽  
Aluminum Accumulation
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