On the role of Ca2+-calmodulin-dependent and cAMP-dependent protein phosphorylation in the circadian rhythm ofNeurospora crassa

1990 ◽  
Vol 159 (6) ◽  
pp. 695-706 ◽  
Author(s):  
D. Techel ◽  
G. Gebauer ◽  
W. Kohler ◽  
T. Braumann ◽  
B. Jastorff ◽  
...  
Keyword(s):  
Circadian Rhythm ◽  
Protein Phosphorylation ◽  
Ofneurospora Crassa ◽  
Dependent Protein

scholarly journals Calcineurin Is an Antagonist to PKA Protein Phosphorylation Required for Postmating Filamentation and Virulence, While PP2A Is Required for Viability in Ustilago maydis

2009 ◽  
Vol 22 (10) ◽  
pp. 1293-1301 ◽  
Author(s):  
John D. Egan ◽  
María D. García-Pedrajas ◽  
David L. Andrews ◽  
Scott E. Gold
Keyword(s):  
Protein Phosphorylation ◽  
Reverse Genetics ◽  
Genetic Model ◽  
Ustilago Maydis ◽  
Catalytic Subunit ◽  
Haploid Strain ◽  
Catalytic Subunits ◽  
Dependent Protein ◽  
Corn Smut

Ustilago maydis is a dimorphic basidiomycete and the causal agent of corn smut disease. It serves as a genetic model for understanding dimorphism, pathogenicity, and mating response in filamentous fungi. Previous studies indicated the importance of regulated cAMP-dependent protein kinase A (PKA) for filamentous growth and pathogenicity in U. maydis. The roles of two protein phosphatases that potentially act antagonistically to PKA were assessed. A reverse genetics approach to mutate the catalytic subunits of calcineurin (CN, protein phosphatase [PP]2B) and PP2A in U. maydis was employed. A mutation in the CN catalytic subunit ucn1 caused a dramatic multiple-budding phenotype and mating between two ucn1 mutants was severely reduced. The pathogenicity of ucn1 mutant strains was also severely reduced, even in a solopathogenic haploid strain. Importantly, mutations disrupting protein phosphorylation by PKA were epistatic to ucn1 mutation, indicating a major role of ucn1 as a PKA antagonistic phosphatase. Genetic and inhibitor studies indicated that the U. maydis PP2A catalytic subunit gene (upa2) was essential.

scholarly journals The role of Ca2+-dependent protein phosphorylation in platelet aggregation

1980 ◽  
Vol 11 (3) ◽  
pp. 379-383 ◽  
Author(s):  
Masakatsu NISHIKAWA ◽  
Yasuharu SASAKI ◽  
Sachiko IKUKAWA ◽  
Hiroyoshi HIDAKA
Keyword(s):  
Platelet Aggregation ◽  
Protein Phosphorylation ◽  
Dependent Protein

The Possible Role of Prolactin in the Circadian Rhythm of Leptin Secretion in Male Rats

2000 ◽  
Vol 224 (3) ◽  
pp. 152-158 ◽  
Author(s):  
C. A. Mastronardi ◽  
A. Walczewska ◽  
W. H. Yu ◽  
S. Karanth ◽  
A. F. Parlow ◽  
...  
Keyword(s):  
Circadian Rhythm ◽  
Male Rats
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