Possible Role of Calcium-Dependent Protein Phosphorylation in Mediating Neurotransmitter Release and Anticonvulsant Action

Epilepsia ◽  
1977 ◽  
Vol 18 (3) ◽  
pp. 357-365 ◽  
Author(s):  
Robert J. Lorenzo ◽  
Steven D. Freedman
Keyword(s):  
Protein Phosphorylation ◽  
Neurotransmitter Release ◽  
Anticonvulsant Action ◽  
Calcium Dependent ◽  
Dependent Protein

scholarly journals A CACNA1A variant associated with trigeminal neuralgia alters the gating of Cav2.1 channels

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Eder Gambeta ◽  
Maria A. Gandini ◽  
Ivana A. Souza ◽  
Laurent Ferron ◽  
Gerald W. Zamponi
Keyword(s):  
Trigeminal Neuralgia ◽  
Missense Mutation ◽  
Neurotransmitter Release ◽  
Trigeminal System ◽  
Wild Type ◽  
Calcium Dependent ◽  
Whole Cell Patch Clamp ◽  
C Terminus ◽  
Dependent Inactivation

AbstractA novel missense mutation in the CACNA1A gene that encodes the pore forming α1 subunit of the CaV2.1 voltage-gated calcium channel was identified in a patient with trigeminal neuralgia. This mutation leads to a substitution of proline 2455 by histidine (P2455H) in the distal C-terminus region of the channel. Due to the well characterized role of this channel in neurotransmitter release, our aim was to characterize the biophysical properties of the P2455H variant in heterologously expressed CaV2.1 channels. Whole-cell patch clamp recordings of wild type and mutant CaV2.1 channels expressed in tsA-201 cells reveal that the mutation mediates a depolarizing shift in the voltage-dependence of activation and inactivation. Moreover, the P2455H mutant strongly reduced calcium-dependent inactivation of the channel that is consistent with an overall gain of function. Hence, the P2455H CaV2.1 missense mutation alters the gating properties of the channel, suggesting that associated changes in CaV2.1-dependent synaptic communication in the trigeminal system may contribute to the development of trigeminal neuralgia.

Calcium-Dependent Protein Phosphorylation in Germinated Pollen

1986 ◽  
pp. 345-346
Author(s):  
Gideon M. Polya ◽  
Vito Micucci ◽  
Anne L. Rae ◽  
Philip J. Harris ◽  
Adrienne E. Clarke
Keyword(s):  
Protein Phosphorylation ◽  
Calcium Dependent ◽  
Dependent Protein ◽  
Germinated Pollen

scholarly journals Ergopeptine-Sensitive Calcium-Dependent Protein Phosphorylation System in the Brain

1984 ◽  
Vol 42 (3) ◽  
pp. 842-855 ◽  
Author(s):  
Carol A. Stratford ◽  
Stephen K. Fisher ◽  
Tetsufumi Ueda
Keyword(s):  
Protein Phosphorylation ◽  
Calcium Dependent ◽  
Dependent Protein ◽  
The Brain

Calcium-dependent protein phosphorylation in morning glory hypocotyls

1992 ◽  
Vol 31 (7) ◽  
pp. 2251-2254 ◽  
Author(s):  
Hikaru Sakamoto ◽  
Sachiko Shibata
Keyword(s):  
Protein Phosphorylation ◽  
Morning Glory ◽  
Calcium Dependent ◽  
Dependent Protein
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