Odontes serotina as a stimulator of regeneration processes in rat liver in chronic toxic hepatitis

The aim of the study was to assess the role of the cellular component of the stroma in liver regeneration after its toxic damage. The experimental model of toxic hepatitis caused by intraperitoneal administration of tetrachloromethane (CCl4) showed that regeneration processes in the liver on the 3rd day are manifested in an increase in binuclear hepatocytes, Ki-67 + cells and hepatocytes dividing by mitosis. The reaction of the stromal component is expressed in an increase in the number of CD45 +, mast and sinusoidal cells (SC). On the 7th day of the development of toxic hepatitis the hepatocyte alteration increases, that is accompanied by a sharp decrease in the mitotic index and the number of Ki-67 + cells. In the stromal component there is a decrease in the number of sinusoidal cells, CD45 + and a significant increase in mast cells with a high secretion granule content.

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Multifocal Osteonecrosis Glucocorticoid Induced

Revista de Chimie ◽

10.37358/rc.17.1.5418 ◽

2017 ◽

Vol 68 (1) ◽

pp. 200-202

Author(s):

Alexandru Patrascu ◽

Liliana Savin ◽

Olivera Lupescu ◽

Dan Mihailescu ◽

Dana Nicoleta Mihai ◽

...

Keyword(s):

Wilson Disease ◽

Toxic Hepatitis ◽

Left Shoulder ◽

Hepatic Transplantation ◽

Number Of Patients ◽

Cementless Prosthesis ◽

Chronic Toxic Hepatitis ◽

Aseptic Osteonecrosis ◽

Hemi Arthroplasty ◽

Protective Treatment

The present study describes a 29 years old patient diagnosed with aseptic osteonecrosis with multiple localization occurred after a corticoid treatment for chronic toxic hepatitis. The clinical and para-clinical examinations determined the diagnosis of Wilson disease and avascular necrosis with multiple localizations. The evolution of the disease was favourable following the surgical treatment consisting of bilateral total hip arthroplasty with cementless prosthesis, hemi-arthroplasty of the left shoulder with cementless prosthesis, orthotopic hepatic transplantation with an entire liver from donor in cerebral death and immunosuppressive, anticoagulant, antiretroviral and gastro-protective treatment. There is an increase of the number of patients undergoing a glucocorticoids treatment for several months, years or lifelong periods. This type of treatment increases the risk of osteonecrosis depending on the dosage and the duration of the treatment.

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PERIODONTAL STATUS IN PATIENTS WITH DISEASES OF HEPATOBILIARY SYSTEM, BURDENED WITH TOBACCO AND DRUG ADDICTION

Wiadomości Lekarskie ◽

10.36740/wlek202003121 ◽

2020 ◽

Vol 73 (3) ◽

pp. 517-520

Author(s):

Anastasia I. Furdychko ◽

Marta P. Ilchyshyn ◽

Irena R. Fedun ◽

Adriana Ya. Barylyak ◽

Oksana M. Slaba ◽

...

Keyword(s):

Iodine Number ◽

Drug Addiction ◽

Toxic Hepatitis ◽

Comparison Group ◽

Periodontal Diseases ◽

Drug Addicts ◽

Periodontal Tissues ◽

Alcoholic Steatohepatitis ◽

The Status ◽

Chronic Toxic Hepatitis

The aim: To study the effect of drug addiction and smoking on the status of periodontal tissues in patients with hepatobiliary pathology. Materials and methods: 58 smokers, 63 drug addicts with hepatobiliary pathology were examined and 92 persons of comparison group (with inflammatory periodontal diseases affected by hepatobiliary pathology, without addiction). Examination of patients included determination of iodine number by Svrakov, S-L and Stallard hygiene indices, PMA index and index PBI. Results: The results of examination of smokers are worse in patients with cirrhosis than in patients with chronic toxic hepatitis and non-alcoholic steatohepatitis and also the results of these two groups was significantly worse than that of the comparison group (iodine number by Svrakov – 1,4 times and 1,3 times higher, PMA index – 1,7 times and 1,4 times worse, in accordance). The results of the study showed that drug addicts patients are worse values in patients with cirrhosis than in patients with chronic toxic hepatitis and non-alcoholic steatohepatitis and also the results of these two groups was significantly worse than that of the comparison group (iodine number by Svrakov – 1,5 times and 1,4 times higher, PMA index – 1,7 times and 1,5 times worse, in accordance). Conclusions: Presence of hepatobiliary pathology in smokers and drug addicts increases the risk of periodontal diseases.

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