Synthesis and antiviral activity of some oxygen-containing heterocyclic compounds

1993 ◽  
Vol 26 (7-8) ◽  
pp. 610-613
Author(s):  
M. G. Zalinyan ◽  
G. G. Danagulyan ◽  
E. A. Abgaryan ◽  
N. G. Balasanyan ◽  
�. R. Kalashyan ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Heterocyclic Compounds

Antiviral Activity of Fluorinated Heterocyclic Compounds

2016 ◽  
Author(s):  
Liubov Biliavska ◽  
Yulia Pankivska ◽  
Olga Povnitsa ◽  
Svitlana Zagorodnya ◽  
Ganna Gudz ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Heterocyclic Compounds ◽  
Strong Antiviral Activity

scholarly journals Nitrogen-Based Heterocyclic Compounds: A Promising Class of Antiviral Agents against Chikungunya Virus

Life ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 16
Author(s):  
Andreza C. Santana ◽  
Ronaldo C. Silva Filho ◽  
José C. J. M. D. S. Menezes ◽  
Diego Allonso ◽  
Vinícius R. Campos
Keyword(s):  
Antiviral Activity ◽  
Mechanism Of Action ◽  
Heterocyclic Compounds ◽  
Chikungunya Virus ◽  
Antiviral Agents ◽  
Antiviral Drug ◽  
Important Class ◽  
Available Nitrogen ◽  
Global Threat ◽  
Present Understanding

Arboviruses, in general, are a global threat due to their morbidity and mortality, which results in an important social and economic impact. Chikungunya virus (CHIKV), one of the most relevant arbovirus currently known, is a re-emergent virus that causes a disease named chikungunya fever, characterized by a severe arthralgia (joint pains) that can persist for several months or years in some individuals. Until now, no vaccine or specific antiviral drug is commercially available. Nitrogen heterocyclic scaffolds are found in medications, such as aristeromycin, favipiravir, fluorouracil, 6-azauridine, thioguanine, pyrimethamine, among others. New families of natural and synthetic nitrogen analogous compounds are reported to have significant anti-CHIKV effects. In the present work, we focus on these nitrogen-based heterocyclic compounds as an important class with CHIKV antiviral activity. We summarize the present understanding on this class of compounds against CHIKV and also present their possible mechanism of action.

scholarly journals Heterocyclic compounds based on 3-(4-bromophenyl) azo-5-phenyl-2(3H)-furanone: Anti-avian influenza virus (H5N1) activity / Heterociklički derivati 3-(4-bromfenil) azo-5-fenil-2(3H)-furanona: Djelovanje na virus ptičje gripe (H5N1)

2012 ◽  
Vol 62 (4) ◽  
pp. 593-606 ◽  
Author(s):  
Eman M. Flefel ◽  
Randa E. Abdel-Mageid ◽  
Waled A. Tantawy ◽  
Mohamed A. Ali ◽  
Abd El-Galil E. Amr
Keyword(s):  
Influenza Virus ◽  
Antiviral Activity ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Heterocyclic Compounds ◽  
Madin Darby Canine Kidney ◽  
Plaque Reduction Assay ◽  
Avian Influenza Virus H5n1 ◽  
Darby Canine Kidney

1 3-[2-(4-Bromphenyl)hydrazono]-5-phenyl-furan-2(3H)-one () was used for preparation of some novel pyrazole, pyridazinone, oxadiazole, triazole, thiazolidine and thioxopyrimidine derivatives. Some of the prepared products were tested for anti-avian influenza virus activity and revealed promising antiviral activity against H5N1 virus [A/Chicken/Egypt/1/20 % (H5N1)] by determination of both EC50 and LD50 and confirmed by plaque reduction assay on Madin-Darby canine kidney cells. Compounds 3-[2-(4-bromophenyl)hydrazono]-5-phenylfuran-2(3H)-one (1), 1-(4-bromophenyl)-N-hydroxy-5-phenyl-1H-pyrazole-3-carboxamide (5) and 1-(4-bromophenyl)-N-{2,3-dihydro-4-hydroxy-3-phenyl-6-oxo-2-thioxopyrimidin-1(6H)-yl}-5-phenyl-1H-pyrazole-3-carboxamide (12a) showed the highest effects. Detailed synthesis, spectroscopic data, and antiviral activity of the synthesized compounds are reported.

Design, synthesis, antiviral activity and mode of action of phenanthrene-containingN-heterocyclic compounds inspired by the phenanthroindolizidine alkaloid antofine

2015 ◽  
Vol 72 (2) ◽  
pp. 371-378 ◽  
Author(s):  
Xiuling Yu ◽  
Peng Wei ◽  
Ziwen Wang ◽  
Yuxiu Liu ◽  
Lizhong Wang ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Mode Of Action ◽  
Heterocyclic Compounds ◽  
Design Synthesis

Probing the Carbon-Nitrogen Bonding in Heterocyclic Compounds with the N K-Shell Excitation Spectroscopy

1997 ◽  
Vol 7 (C2) ◽  
pp. C2-527-C2-528
Author(s):  
St Bender ◽  
R. Franke ◽  
J. Hormes ◽  
A. A. Pavlychev ◽  
N. G. Fominykh ◽  
...  
Keyword(s):  
Heterocyclic Compounds

Antiviral activity of EPs® 7630 as assessed in a fibroblast-virus protection assay

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
C Thaele ◽  
A Janecki ◽  
AF Kiderlen ◽  
H Kolodziej
Keyword(s):  
Antiviral Activity ◽  
Protection Assay
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