Effect of paraaminobenzoic acid on cholesterol synthesis and breakdown in the liver of intact and atherosclerotic rabbits

1963 ◽  
Vol 56 (4) ◽  
pp. 1089-1091
Author(s):  
A. F. Ryzhova
Keyword(s):  
Cholesterol Synthesis ◽  
Paraaminobenzoic Acid

Lamin B receptor: role on chromatin structure, cellular senescence and possibly aging

2020 ◽  
Vol 477 (14) ◽  
pp. 2715-2720
Author(s):  
Susana Castro-Obregón
Keyword(s):  
Cellular Senescence ◽  
Nuclear Membrane ◽  
Chromatin Structure ◽  
Cholesterol Synthesis ◽  
Reductase Activity ◽  
Chimeric Protein ◽  
Nuclear Lamina ◽  
Lamin B ◽  
Inner Nuclear Membrane ◽  
Lamin B Receptor

The nuclear envelope is composed by an outer nuclear membrane and an inner nuclear membrane, which is underlain by the nuclear lamina that provides the nucleus with mechanical strength for maintaining structure and regulates chromatin organization for modulating gene expression and silencing. A layer of heterochromatin is beneath the nuclear lamina, attached by inner nuclear membrane integral proteins such as Lamin B receptor (LBR). LBR is a chimeric protein, having also a sterol reductase activity with which it contributes to cholesterol synthesis. Lukasova et al. showed that when DNA is damaged by ɣ-radiation in cancer cells, LBR is lost causing chromatin structure changes and promoting cellular senescence. Cellular senescence is characterized by terminal cell cycle arrest and the expression and secretion of various growth factors, cytokines, metalloproteinases, etc., collectively known as senescence-associated secretory phenotype (SASP) that cause chronic inflammation and tumor progression when they persist in the tissue. Therefore, it is fundamental to understand the molecular basis for senescence establishment, maintenance and the regulation of SASP. The work of Lukasova et al. contributed to our understanding of cellular senescence establishment and provided the basis that lead to the further discovery that chromatin changes caused by LBR reduction induce an up-regulated expression of SASP factors. LBR dysfunction has relevance in several diseases and possibly in physiological aging. The potential bifunctional role of LBR on cellular senescence establishment, namely its role in chromatin structure together with its enzymatic activity contributing to cholesterol synthesis, provide a new target to develop potential anti-aging therapies.

Cholesterol Synthesis Inhibition

2020 ◽  
Author(s):  
Keyword(s):  
Cholesterol Synthesis ◽  
Synthesis Inhibition

Total gastrectomy and small intestinal cholesterol synthesis in diabetic rats

Diabetes ◽  
1989 ◽  
Vol 38 (2) ◽  
pp. 219-224
Author(s):  
K. R. Feingold ◽  
Q. H. Zeng ◽  
M. Soued ◽  
A. Siperstein ◽  
M. K. Serio ◽  
...  
Keyword(s):  
Total Gastrectomy ◽  
Cholesterol Synthesis ◽  
Diabetic Rats ◽  
Small Intestinal

Targeting Matrix Metalloproteinases in Atherosclerosis and Cardiovascular Dysfunction

2019 ◽  
Vol 70 (2) ◽  
pp. 718-720
Author(s):  
Lucia Corina Dima-Cozma ◽  
Sebastian Cozma ◽  
Delia Hinganu ◽  
Cristina Mihaela Ghiciuc ◽  
Florin Mitu
Keyword(s):  
Smooth Muscle ◽  
Matrix Metalloproteinases ◽  
Cholesterol Synthesis ◽  
Balloon Dilation ◽  
Aortic Aneurysms ◽  
Arterial Lesions ◽  
Smooth Muscle Cell Migration ◽  
And Migration

Matrix metalloproteinases (MMPs) are the primary mediators of extracellular remodeling and their properties are useful in diagnostic evaluation and treatment. They are zinc-dependent proteases. MMPs have been involved in the mechanisms of atherosclerosis in various arterial areas, ischemic heart disease and myocardial infarction, atrial fibrillation and aortic aneurysms. Recently, MMP9 has been implicated in dyslipidemia and cholesterol synthesis by the liver. Increased MMP expression and activity has been associated with neointimal arterial lesions and migration of smooth muscle cells after arterial balloon dilation, while MMP inhibition decreases smooth muscle cell migration in vivo and in vitro.

scholarly journals Angptl4 Upregulates Cholesterol Synthesis in Liver via Inhibition of LPL- and HL-Dependent Hepatic Cholesterol Uptake

2007 ◽  
Vol 27 (11) ◽  
pp. 2420-2427 ◽  
Author(s):  
Laeticia Lichtenstein ◽  
Jimmy F.P. Berbée ◽  
Susan J. van Dijk ◽  
Ko Willems van Dijk ◽  
André Bensadoun ◽  
...  
Keyword(s):  
Cholesterol Synthesis ◽  
Hepatic Cholesterol ◽  
Cholesterol Uptake

scholarly journals Ketogenesis and Cholesterol Synthesis in Normal and Neoplastic Tissues of the Rat

1969 ◽  
Vol 244 (15) ◽  
pp. 4251-4256 ◽  
Author(s):  
J D McGarry ◽  
D W Foster
Keyword(s):  
Cholesterol Synthesis ◽  
Neoplastic Tissues

scholarly journals Effect of vitamin D3 derivatives on cholesterol synthesis and HMG-CoA reductase activity in cultured cells.

1989 ◽  
Vol 30 (3) ◽  
pp. 379-386
Author(s):  
A K Gupta ◽  
R C Sexton ◽  
H Rudney
Keyword(s):  
Vitamin D3 ◽  
Cholesterol Synthesis ◽  
Cultured Cells ◽  
Reductase Activity ◽  
Hmg Coa Reductase ◽  
Coa Reductase

scholarly journals Normal and inhibited cholesterol synthesis in the cultured rat embryo.

1997 ◽  
Vol 38 (1) ◽  
pp. 22-34
Author(s):  
B Llirbat ◽  
C Wolf ◽  
F Chevy ◽  
D Citadelle ◽  
G Bereziat ◽  
...  
Keyword(s):  
Cholesterol Synthesis ◽  
Rat Embryo
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