Effect of antrectomy of gastric secretion induced by insulin hypoglycemia in dogs

1977 ◽  
Vol 83 (3) ◽  
pp. 298-301
Author(s):  
A. A. Fisher ◽  
Yu. M. Zubenko ◽  
R. I. Polyak
Keyword(s):  
Gastric Secretion ◽  
Insulin Hypoglycemia

Gastric Secretion Following Vagosplanchnic Nerve Anastomosis

1956 ◽  
Vol 184 (2) ◽  
pp. 418-427 ◽  
Author(s):  
Anthony M. Imparato ◽  
L. Corsan Reid ◽  
J. William Hinton
Keyword(s):  
Electrical Stimulation ◽  
Gastric Secretion ◽  
Functional Relationship ◽  
Early Postoperative Period ◽  
Insulin Hypoglycemia ◽  
Splanchnic Nerves ◽  
Nerve Anastomosis ◽  
Nerve Anastomoses ◽  
Secretory Apparatus ◽  
Stimulation Of

Gastric secretion in response to insulin hypoglycemia and electrical stimulation of the vagus was studied in 18 dogs who had bilateral vagosplanchnic anastomoses in the chest. In six dogs the pattern of gastric secretory response to insulin changed from negative in the early postoperative period to positive between 85 and 613 days postanastomosis. In two, apparent return of vagus function was confirmed by electrical stimulation of the vagi. One of five dogs in whom splanchnovagal nerve anastomoses were performed showed a return of response to insulin at 63 days which was abolished by excision of the anastomoses. On the basis of a review of some of the ideas regarding interpretation of cross nerve anastomoses and some of the conflicting opinions regarding the fiber content of the sympathetic splanchnic nerves, the authors conclude the most likely explanation for the observed phenomena is that there are preganglionic cholinergic fibers in the greater splanchnic nerves whose relationship to the gastric secretory apparatus is similar to that of cholinergic fibers in the vagus. The regenerating fibers of the vagus followed the sheaths of these degenerating fibers and re-established functional relationship with the gastric secretory apparatus.

Alterations in gastric secretion following hypothalamic lesions producing hyperphagia

1965 ◽  
Vol 209 (2) ◽  
pp. 319-323 ◽  
Author(s):  
Peter T. Ridley ◽  
Frank P. Brooks
Keyword(s):  
Food Intake ◽  
Gastric Secretion ◽  
Neural Control ◽  
Neural Mechanisms ◽  
Gastric Fistula ◽  
Central Regulation ◽  
Pepsin Secretion ◽  
Insulin Hypoglycemia ◽  
Hypothalamic Lesions

Fasting gastric secretion and secretion during insulin hypoglycemia were collected from hypothalamic hyperphagic rats equipped with chronic gastric fistula in an attempt to correlate the hypothalamic neural mechanisms controlling food intake with gastric secretion. The interdigestive or basal fasting secretion of rats rendered hyperphagic by stereotaxic ablation of the ventromedial nuclei was significantly increased in volume, acid concentration and output, and pepsin output when compared with control and sham-operated rats and rats with hypothalamic lesions without hyperphagia. Hypothalamic hyperphagic rats did not show a significant increase in gastric secretion during insulin hypoglycemia, whereas the other groups did. The levels of hypoglycemia induced by insulin were comparable in all groups. These studies suggest an important role of the ventromedial nuclei in the central regulation of acid and pepsin secretion, and also relate the hypothalamic neural control of gastric secretion to that of food intake. The results also indicate that this nucleus is involved either as a "center" or pathway in the augmentation of gastric secretion by insulin hypoglycemia.

Inhibitory Effect of Pancreatic Secretin on Gastric Secretion

1957 ◽  
Vol 190 (3) ◽  
pp. 396-402 ◽  
Author(s):  
Herbert B. Greenlee ◽  
Enrique H. Longhi ◽  
Jose Delgadillo Guerrero ◽  
Thomas S. Nelsen ◽  
Abdul Latif El-Bedri ◽  
...  
Keyword(s):  
Gastric Secretion ◽  
Intravenous Injection ◽  
Inhibitory Effect ◽  
The Other ◽  
Gastrin Release ◽  
Depressant Effect ◽  
Insulin Hypoglycemia ◽  
Heidenhain Pouch ◽  
Marked Inhibition ◽  
Inhibition Of Gastric Secretion

In dogs prepared with both a vagus denervated Heidenhain pouch and a total pancreatic fistula, the intravenous injection of pancreatic secretin (Lilly) produced a profuse secretion of pancreatic juice and a simultaneous marked inhibition of gastric secretion. In dogs prepared with an isolated antrum pouch and a Heidenhain pouch the gastric secretion induced by the instillation of food in the antrum pouch was completely inhibited by the intravenous injection of pancreatic secretin. On the other hand, the intravenous injection of pancreatic secretin had little or no effect on the secretion of gastric juice produced by insulin hypoglycemia or by the injection of histamine. It is suggested that pancreatic secretin may represent the mechanism by means of which acid food in the duodenum inhibits gastric secretion. It is probable that this inhibition is caused by prevention of gastrin release from the antrum rather than to a depressant effect on the parietal cells.

Gastric Secretion and Free Histamine in Urine

1958 ◽  
Vol 195 (1) ◽  
pp. 202-208 ◽  
Author(s):  
William T. Irvine ◽  
Charles F. Code
Keyword(s):  
Gastric Secretion ◽  
Gastric Juice ◽  
Free Acid ◽  
Secretory Response ◽  
Active Secretion ◽  
Insulin Hypoglycemia ◽  
Urinary Histamine ◽  
Made In

Simultaneous determinations of the hourly outputs of free histamine in the urine and free acid in the juice from Heidenhain gastric pouches were made in dogs after the ingestion of meat. The gastric secretory response to the meal was separated into intestinal and gastric components. The rough parallelism, noted by others, between the outputs of acid in the gastric juice and free histamine in the urine after the meal was verified. When the meat was placed in the jejunum the output of histamine in the urine promptly increased while the output of acid was minimal or absent. Later, the output of acid increased while the output of histamine declined. Meat placed in the isolated stomach produced active secretion of acid but no increase in urinary histamine. No increase of urinary histamine followed a meal of bread and milk. During nervous secretion induced by insulin hypoglycemia, the output of free histamine in the urine did not change.

Inhibition of cephalic and antral phases of gastric secretion by antral chalone

1962 ◽  
Vol 202 (4) ◽  
pp. 716-720 ◽  
Author(s):  
James C. Thompson ◽  
Harvey J. Lerner ◽  
Jorge A. Tramontana
Keyword(s):  
Hydrochloric Acid ◽  
Gastric Secretion ◽  
Portal Vein ◽  
Acid Secretion ◽  
Acid Output ◽  
Insulin Hypoglycemia ◽  
Heidenhain Pouch ◽  
Pavlov Pouch

The effect of antral acidification on the antral and cephalic phases of gastric secretion has been studied. Cross-transfusions were carried out between pairs of dogs in which blood from the portal vein of one dog was administered to another dog with a denervated fundic pouch. Transfusion of blood collected during acidification of the antrum resulted in a diminution of Heidenhain pouch acid secretion in response to food and to topical acetylcholine of 64% and 83%, respectively. The effect of antral acidification on gastric secretion stimulated by insulin hypoglycemia was studied in dogs prepared with Pavlov and isolated antral pouches (innervated and denervated). Irrigation of the antral pouch with .1 n hydrochloric acid resulted in a 92% decrease in Pavlov pouch acid output.

Inhibition of Vagally Stimulated Gastric Acid by the Pyloric Antrum

1958 ◽  
Vol 194 (3) ◽  
pp. 531-534 ◽  
Author(s):  
H. J. Shimizu ◽  
R. T. Morrison ◽  
R. C. Harrison
Keyword(s):  
Gastric Secretion ◽  
Gastric Acid ◽  
Acid Production ◽  
Vagal Stimulation ◽  
Gastric Pouch ◽  
Pyloric Antrum ◽  
Insulin Hypoglycemia ◽  
Intestinal Origin ◽  
The Difference

It has been previously demonstrated that gastric acid production of antral and intestinal origin is inhibited by acidification of the antrum. In this experiment a vagally innervated gastric pouch (Hollander) and an excluded antral pouch were constructed in four animals, two of the antral pouches being vagally innervated and two denervated. The gastric pouches were stimulated to secrete in response to insulin hypoglycemia and the effect of acidification of the antrum tested. It was found that gastric secretion was reduced by acidification whether the antrum was denervated or not, the difference between the two being insignificant. It was concluded that the gastric acid produced in response to vagal stimulation is reduced by acidification of the antrum and that denervation of the antrum did not influence this result.

Vagal Gastric Secretory Nerves in the Rat Demonstrated With Insulin

1957 ◽  
Vol 191 (2) ◽  
pp. 262-264 ◽  
Author(s):  
Ardelle Lane ◽  
A. C. Ivy ◽  
E. K. Ivy
Keyword(s):  
Gastric Secretion ◽  
Secretory Response ◽  
Gastric Fistula ◽  
Vagus Nerves ◽  
Insulin Hypoglycemia

It was found in four tests on each of 12 rats with a chronic gastric fistula and accustomed to the experimental procedures that insulin hypoglycemia short of convulsions stimulated gastric secretion when the vagus nerves were intact. In five tests on each of seven rats, it was found that section of the vagi abolished the secretory response to insulin hypoglycemia. This evidence is interpreted as establishing the presence of gastric secretory nerves in the vagi of the rat.

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