Intracellular investigation of an anaphylactic reaction of guinea pig atrial cells

1968 ◽  
Vol 65 (1) ◽  
pp. 23-26
Author(s):  
I. S. Gushchin
Keyword(s):  
Guinea Pig ◽  
Anaphylactic Reaction ◽  
Atrial Cells ◽  
Intracellular Investigation

scholarly journals ALLERGIC IRRITABILITY

1925 ◽  
Vol 41 (3) ◽  
pp. 327-335 ◽  
Author(s):  
Paul A. Lewis ◽  
Dorothy Loomis
Keyword(s):  
Guinea Pig ◽  
Anaphylactic Reaction ◽  
Inbred Lines ◽  
Reaction Complex

Inbred lines of guinea pig which have previously been observed to differ in their susceptibility to tuberculosis differ in their anaphylactic responses as well. The families that are relatively resistant to tuberculosis appear also to be somewhat more resistant to some one or more of the phases of the anaphylactic reaction complex.

scholarly journals Histamine H1 -receptor-mediated modulation of the delayed rectifier K+ current in guinea-pig atrial cells: opposite effects on IKs and IKr

1999 ◽  
Vol 128 (7) ◽  
pp. 1545-1553 ◽  
Author(s):  
Yasunori Matsumoto ◽  
Takehiko Ogura ◽  
Hiroko Uemura ◽  
Toshihiro Saito ◽  
Yoshiaki Masuda ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Delayed Rectifier ◽  
H1 Receptor ◽  
Histamine H1 Receptor ◽  
Atrial Cells ◽  
K Current

Anaphylactic Reaction in the Phrenic Nerve of the Guinea-Pig

1972 ◽  
Vol 3 (6) ◽  
pp. 291-298 ◽  
Author(s):  
Jesús G. Ninomiya ◽  
Enrique Gijón ◽  
Francisco Alonso-deflorida
Keyword(s):  
Guinea Pig ◽  
Anaphylactic Reaction ◽  
Phrenic Nerve

Rectification of muscarinic K+ current by magnesium ion in guinea pig atrial cells

1987 ◽  
Vol 253 (1) ◽  
pp. H210-H214
Author(s):  
M. Horie ◽  
H. Irisawa
Keyword(s):  
Guinea Pig ◽  
Action Potentials ◽  
Single Channel ◽  
Outward Current ◽  
Atrial Cells ◽  
Voltage Dependent ◽  
K Current ◽  
Single Channel Currents ◽  
Channel Currents ◽  
Low K

Rectifying properties of the acetylcholine (ACh)-sensitive K+ channels were studied using a patch-clamp method in single atrial cells prepared enzymatically from adult guinea pig hearts. In the presence of micromolar concentration of nonhydrolyzable guanosine 5'-triphosphate (GTP) analogue 5'-guanylylimidodiphosphate (GppNHp) and the absence of Mg2+ at the inner surface of patch membrane [( Mg2+]i), the channel activity recovered in inside-out patch condition. The single channel conductance became ohmic between -80 and +80 mV (symmetrical 150 mM K+ solutions). The rapid relaxation of outward single channel currents was disclosed on a depolarization. [Mg2+]i blocked the outward current through the channel dose- and voltage-dependently and also induced a dose-dependent increase in the channel activation. The apparent paradoxical role of [Mg2+]i is important for the cholinergic control in the heart; voltage-dependent Mg block ensures a low K+ conductance of cell membrane at the plateau of action potentials during the exposure to ACh, thereby slowing the heart rate without unfavorable shortening of the action potentials.

Influence of capsaicin on anaphylactic reaction in the guinea-pig

1988 ◽  
Vol 20 ◽  
pp. 17-18
Author(s):  
S. Franchi Micheli ◽  
G. Gentilini ◽  
M. Ciuffi ◽  
S. Luzzi ◽  
L. Zilletti
Keyword(s):  
Guinea Pig ◽  
Anaphylactic Reaction

Ionic diffusion in transverse tubules of cardiac ventricular myocytes

1998 ◽  
Vol 275 (3) ◽  
pp. H852-H860 ◽  
Author(s):  
Neal Shepherd ◽  
Holly B. McDonough
Keyword(s):  
Guinea Pig ◽  
Calcium Ions ◽  
Rate Of Change ◽  
Slow Phase ◽  
Total Current ◽  
Transverse Tubules ◽  
Current Increase ◽  
Atrial Cells ◽  
Ventricular Cells ◽  
Current Change

We have estimated the rate of diffusion of calcium ions in the transverse tubules of isolated cardiocytes by recording changes in peak calcium current ( I Ca) caused by rapid changes of the extracellular calcium concentration ([Ca]o) at various intervals just preceding activation of I Ca. Isolated ventricular cells of guinea pig heart and atrial cells from rabbit heart were voltage-clamped (whole cell patch), superfused at a high flow rate, and stimulated continuously with depolarizing pulses (0.5 Hz, 200- or 20-ms pulses from a holding potential of −45 or −75 mV to 0 mV). In ventricular cells, the change in peak I Ca following a sudden change of [Ca]oincreased rapidly as the delay between the solution change and depolarization was increased, up to a delay of ∼75 ms [time constant (τ) ≈ 20 ms, 30–40% of total current change), and then increased more slowly (τ ≈ 200 ms, 60–70% of total current change); 400–500 ms were needed to achieve 90% of the total current increase. In atrial cells, a clear separation into two phases was not possible and 90% of the current change occurred within 85 ms. The slow phase of current change, which was unique to the ventricular cells, presumably reflects the slow equilibration of ions between the bulk perfusate and the lumina of the transverse tubules. If the lengths of the transverse tubules were equal to the cell thickness, the slow rate of change of current would be consistent with an apparent diffusion coefficient for calcium ions of 0.95 × 10−6cm2/s, considerably smaller than the value in bulk solution (7.9 × 10−6cm2/s). Most likely, this discrepancy is due to a high degree of tortuosity in the transverse tubular system in guinea pig ventricular cells or possibly to ion binding sites within the tubular membranes and glycocalyx.

Anticholinergic Effects of Class III Antiarrhythmic Drugs in Guinea Pig Atrial Cells

Circulation ◽  
1995 ◽  
Vol 91 (11) ◽  
pp. 2834-2843 ◽  
Author(s):  
Katsumi Mori ◽  
Yukio Hara ◽  
Toshihiro Saito ◽  
Yoshiaki Masuda ◽  
Haruaki Nakaya
Keyword(s):  
Guinea Pig ◽  
Antiarrhythmic Drugs ◽  
Class Iii ◽  
Anticholinergic Effects ◽  
Atrial Cells

A slow and progressive action of cyanide on the anaphylactic reaction of guinea pig lung slices

1965 ◽  
Vol 14 (5) ◽  
pp. 683-692 ◽  
Author(s):  
A. Prouvost-Danon ◽  
M.Silva Lima ◽  
M.Queiroz da Cruz ◽  
H. Moussatché
Keyword(s):  
Guinea Pig ◽  
Anaphylactic Reaction
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