Effects of N-acetylaspartic acid on the brain after frontal lobectomy in rats: Antiamnestic effect and influence on monoamine content

The pathophysiology of mental illness and its relationship to the frontal lobe were subjects of immense interest in the latter half of the 19th century. Numerous studies emerged during this time on cortical localization and frontal lobe theory, drawing upon various ideas from neurology and psychiatry. Reflecting the intense interest in this region of the brain, the 1935 International Neurological Congress in London hosted a special session on the frontal lobe. Among other presentations, Yale physiologists John Fulton and Carlyle Jacobsen presented a study on frontal lobectomy in primates, and neurologist Richard Brickner presented a case of frontal ablation for olfactory meningioma performed by the Johns Hopkins neurosurgeon Walter Dandy. Both occurrences are said to have influenced Portuguese neurologist Egas Moniz (1874–1955) to commence performing leucotomies on patients beginning in late 1935. Here the authors review the relevant events related to frontal lobe theory leading up to the 1935 Neurological Congress as well as the extent of this meeting’s role in the genesis of the modern era of psychosurgery.

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The Monoamine Content of the Brain in the Neurofilament-Deficient Quail, (the Quiver Quail).

Biological and Pharmaceutical Bulletin ◽

10.1248/bpb.17.1053 ◽

1994 ◽

Vol 17 (8) ◽

pp. 1053-1055 ◽

Cited By ~ 3

Author(s):

Hiroyuki HASEGAWA ◽

Toshihiko MURAYAMA ◽

Akemi TAKAHASHI ◽

Chitoshi ITAKURA ◽

Yasuyuki NOMURA

Keyword(s):

The Brain ◽

Monoamine Content

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RAT THYROID ACTIVITY AND COLD RESPONSE AFTER REMOVAL OF FRONTAL PARTS OF THE BRAIN

Acta Endocrinologica ◽

10.1530/acta.0.0370470 ◽

1961 ◽

Vol 37 (3) ◽

pp. 470-478 ◽

Cited By ~ 4

Author(s):

L. van Beugen ◽

J. J. van der Werff ten Bosch

Keyword(s):

Room Temperature ◽

Anterior Commissure ◽

Vaginal Smear ◽

Surgical Removal ◽

Thyroid Activity ◽

Olfactory Bulbs ◽

Cold Response ◽

Rat Thyroid ◽

The Brain ◽

Frontal Lobectomy

ABSTRACT Thyroid activity was studied in rats after surgical removal of the frontal parts of the brain and in intact and blank-operated animals. The index of thyroid function used was the biological half-life of thyroidal 131I calculated from the amounts of 131I present in the thyroid gland, one and eight days after i. p. administration of the tracer. It was found that removal of all the brain tissue three mm anterior to the anterior commissure, including the olfactory bulbs, did not alter thyroid activity at room temperature and that the normal rise in thyroid activity occurred after this operation when the animals were exposed to an environmental temperature of + 4° C for 15 days. It is concluded that the frontal parts of the brain are not essential either for normal thyroid activity or for the thyroid response to cold. Vaginal smear cycles were also normal after »frontal lobectomy«.

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