Dual expression of CD45RA and CD45RO isoforms on myelin basic protein-specific CD4+ T-cell lines in multiple sclerosis

1993 ◽  
Vol 13 (2) ◽  
pp. 152-161 ◽  
Author(s):  
Yufen Qin ◽  
Stanley van den Noort ◽  
Jeff Kurt ◽  
Sudhir Gupta
Keyword(s):  
Multiple Sclerosis ◽  
T Cell ◽  
Myelin Basic Protein ◽  
Cell Lines ◽  
Basic Protein ◽  
Cd4 T Cell ◽  
T Cell Lines ◽  
Dual Expression

Citrulline-containing myelin basic protein is recognized by T-cell lines derived from multiple sclerosis patients and healthy individuals

Neurology ◽  
1994 ◽  
Vol 44 (1) ◽  
pp. 123-123 ◽  
Author(s):  
R. Martin ◽  
J. N. Whitaker ◽  
L. Rhame ◽  
R. R. Goodin ◽  
H. F. McFarland
Keyword(s):  
Multiple Sclerosis ◽  
T Cell ◽  
Myelin Basic Protein ◽  
Cell Lines ◽  
Basic Protein ◽  
Healthy Individuals ◽  
T Cell Lines ◽  
Multiple Sclerosis Patients

scholarly journals Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis.

1994 ◽  
Vol 179 (3) ◽  
pp. 973-984 ◽  
Author(s):  
J Zhang ◽  
S Markovic-Plese ◽  
B Lacet ◽  
J Raus ◽  
H L Weiner ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
T Cells ◽  
Cerebrospinal Fluid ◽  
T Cell ◽  
Myelin Basic Protein ◽  
Cell Lines ◽  
Basic Protein ◽  
Proteolipid Protein ◽  
Normal Individuals ◽  
T Cell Lines

Equal numbers of CD4+ T cells recognizing myelin basic protein (MBP) and proteolipid protein (PLP) are found in the circulation of normal individuals and multiple sclerosis (MS) patients. We hypothesized that if myelin-reactive T cells are critical for the pathogenesis of MS, they would exist in a different state of activation as compared with myelin-reactive T cells cloned from the blood of normal individuals. This was investigated in a total of 62 subjects with definitive MS. While there were no differences in the frequencies of MBP- and PLP-reactive T cells after primary antigen stimulation, the frequency of MBP or PLP but not tetanus toxoid-reactive T cells generated after primary recombinant interleukin (rIL-2) stimulation was significantly higher in MS patients as compared with control individuals. Primary rIL-2-stimulated MBP-reactive T cell lines were CD4+ and recognized MBP epitopes 84-102 and 143-168 similar to MBP-reactive T cell lines generated with primary MBP stimulation. In the cerebrospinal fluid (CSF) of MS patients, MBP-reactive T cells generated with primary rIL-2 stimulation accounted for 7% of the IL-2-responsive cells, greater than 10-fold higher than paired blood samples, and these T cells also selectively recognized MBP peptides 84-102 and 143-168. In striking contrast, MBP-reactive T cells were not detected in CSF obtained from patients with other neurologic diseases. These results provide definitive in vitro evidence of an absolute difference in the activation state of myelin-reactive T cells in the central nervous system of patients with MS and provide evidence of a pathogenic role of autoreactive T cells in the disease.

Antigen-dependent HLA-DR-restricted lysis of human astrocytes by CD4+ T-cell lines specific for myelin-basic protein (MBP)

1991 ◽  
Vol 35 ◽  
pp. 125
Author(s):  
F. Weber ◽  
E. Meinl ◽  
F. Aloisi ◽  
G. Borsellino ◽  
R. Hohlfeld ◽  
...  
Keyword(s):  
T Cell ◽  
Myelin Basic Protein ◽  
Cell Lines ◽  
Basic Protein ◽  
Cd4 T Cell ◽  
Human Astrocytes ◽  
Hla Dr ◽  
T Cell Lines

Target epitopes of myelin basic protein specific T cell lines in multiple sclerosis

1993 ◽  
Vol 14 (2) ◽  
pp. 139-143 ◽  
Author(s):  
G. Ristori ◽  
M. Salvetti ◽  
C. Buttinelli ◽  
M. Falcone ◽  
S. Trabace ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
T Cell ◽  
Myelin Basic Protein ◽  
Cell Lines ◽  
Basic Protein ◽  
T Cell Lines

Regulation of myelin basic protein-specific helper T cells in multiple sclerosis: Generation of suppressor T cell lines

1992 ◽  
Vol 139 (1) ◽  
pp. 118-130 ◽  
Author(s):  
Zhang Jingwu ◽  
Marleen Schreurs ◽  
Robert Medaer ◽  
Jef C.M. Raus
Keyword(s):  
Multiple Sclerosis ◽  
T Cells ◽  
T Cell ◽  
Myelin Basic Protein ◽  
Cell Lines ◽  
Basic Protein ◽  
Helper T Cells ◽  
Suppressor T Cell ◽  
T Cell Lines

Human myelin basic protein (MBP) epitopes recognized by mouse MBP-selected T cell lines from multiple sclerosis patients

1994 ◽  
Vol 49 (1-2) ◽  
pp. 45-50 ◽  
Author(s):  
Yuan K. Chou ◽  
Richard E. Jones ◽  
Dennis Bourdette ◽  
Ruth Whithman ◽  
George Hashim ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
T Cell ◽  
Myelin Basic Protein ◽  
Cell Lines ◽  
Basic Protein ◽  
T Cell Lines ◽  
Multiple Sclerosis Patients
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