Glutamate decarboxylase activity in the substantia nigra and the hippocampus of rats microinjected with inhibitors of the enzyme

1991 ◽  
Vol 16 (3) ◽  
pp. 263-267 ◽  
Author(s):  
Ricardo Tapia ◽  
Patricia Salazar
Keyword(s):  
Substantia Nigra ◽  
Glutamate Decarboxylase ◽  
Decarboxylase Activity

scholarly journals Decrease of Glutamate Decarboxylase Activity in Substantia Nigra and Caudoputamen following Transient Hyperglycemic Ischemia in the Rat

1989 ◽  
Vol 9 (6) ◽  
pp. 897-901 ◽  
Author(s):  
Jaroslava Folbergrová ◽  
Maj-Lis Smith ◽  
Kenji Inamura ◽  
Bo K. Siesjö
Keyword(s):  
Cerebral Cortex ◽  
Substantia Nigra ◽  
Glutamate Decarboxylase ◽  
Cell Damage ◽  
Decarboxylase Activity ◽  
Transient Ischemia ◽  
Inhibitory Transmission ◽  
Generalized Seizures ◽  
Postischemic Period ◽  
Gad Activity

Glutamate decarboxylase (GAD) activity was determined in caudoputamen (CP), substantia nigra (SN), and cerebral cortex (CCX) after 19–22 h of recirculation following 10 min of transient ischemia in hyperglycemic rats, i.e., under the conditions when previously a pronounced nerve cell damage was demonstrated in both CP and SN. The present results demonstrate a decrease of GAD activity in SN by 30% and in CP by 22% and no change in CCX. No statistically significant change in GAD activity could be detected in SN, CP, or CCX 1,4, and 7 days following 10 min of ischemia in normoglycemic animals. The decrease of GAD activity in SN at the time preceding the onset of postischemic seizures suggests that there may be an imbalance between augmented excitatory and decreased inhibitory transmission in SN. We tentatively conclude that this may increase the probability of generalized seizures in the postischemic period following ischemia in hyperglycemic animals.

scholarly journals Effect of undernutrition in early life on glutamate decarboxylase activity in the adult brain

1972 ◽  
Vol 130 (1) ◽  
pp. 12P-12P ◽  
Author(s):  
B P F Adlard ◽  
J Dobbing ◽  
A Lynch ◽  
R Balázs ◽  
A P Reynolds
Keyword(s):  
Glutamate Decarboxylase ◽  
Early Life ◽  
Adult Brain ◽  
Decarboxylase Activity

Two approaches to the determination of glutamate decarboxylase activity in vivo

1979 ◽  
Vol 4 (5) ◽  
pp. 702
Author(s):  
L.P. Miller ◽  
J.R. Walters ◽  
D.L. Martin ◽  
N. Eng
Keyword(s):  
Glutamate Decarboxylase ◽  
Decarboxylase Activity

Glutamate decarboxylase activity in brain regions of differentially-housed mice; a difference in the olfactory bulb

1980 ◽  
Vol 36 (7) ◽  
pp. 853-854 ◽  
Author(s):  
J. M. Blindermann ◽  
F. V. DeFeudis ◽  
M. Maitre ◽  
R. Misslin ◽  
P. Mandel
Keyword(s):  
Olfactory Bulb ◽  
Glutamate Decarboxylase ◽  
Brain Regions ◽  
Decarboxylase Activity

Modifications of brain glutamate decarboxylase activity by pyridoxal phosphate-γ-glutamyl hydrazone

1967 ◽  
Vol 16 (7) ◽  
pp. 1211-1218 ◽  
Author(s):  
Ricardo Tapia ◽  
Miguel Pérez De La Mora ◽  
Guillermo H. Massieu
Keyword(s):  
Glutamate Decarboxylase ◽  
Pyridoxal Phosphate ◽  
Decarboxylase Activity
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