Role of adrenoreactive structures of the amygdaloid complex in the regulation of blood coagulation

SummaryThe role of intravascular coagulation in the production of the generalized Shwartzman phenomenon has been evaluated. The administration of endotoxin to animals prepared with Thorotrast results in activation of the coagulation mechanism with the resultant deposition of fibrinoid material in the renal glomeruli. Anticoagulation prevents alterations in the state of the coagulation system and inhibits development of the renal lesions. Platelets are not primarily involved. Platelet antiserum produces similar lesions in animals prepared with Thorotrast, but appears to do so in a manner which does not significantly involve intravascular coagulation.The production of adrenal cortical hemorrhage, comparable to that seen in the Waterhouse-Friderichsen syndrome, following the administration of endotoxin to animals that had previously received ACTH does not require intravascular coagulation and may not be a manifestation of the generalized Shwartzman phenomenon.

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THE RÔLE OF CEPHALIN IN BLOOD COAGULATION

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)85936-1 ◽

1922 ◽

Vol 50 (2) ◽

pp. 455-462

Author(s):

André Gratia ◽

P.A. Levene

Keyword(s):

Blood Coagulation

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Experimental and theoretical evidence supporting the role of Gly363 in blood coagulation factor IXa (Gly193 in chymotrypsin) for proper activation of the proenzyme.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)39894-1 ◽

1990 ◽

Vol 265 (5) ◽

pp. 2956-2961

Author(s):

S P Bajaj ◽

S G Spitzer ◽

W J Welsh ◽

B J Warn-Cramer ◽

C K Kasper ◽

...

Keyword(s):

Blood Coagulation ◽

Coagulation Factor ◽

Factor Ixa ◽

Theoretical Evidence

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On the Role of a Protein Inhibitor in the First Stage of Blood Coagulation

Archives Internationales de Physiologie ◽

10.3109/13813455109144971 ◽

1951 ◽

Vol 58 (4) ◽

pp. 386-411 ◽

Cited By ~ 4

Author(s):

Silvio Fiala

Keyword(s):

Blood Coagulation ◽

Protein Inhibitor

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The Role of Factor XI in a Dilute Thromboplastin Assay of Extrinsic Coagulation Pathway

Thrombosis and Haemostasis ◽

10.1055/s-0037-1615963 ◽

2001 ◽

Vol 85 (06) ◽

pp. 1055-1059 ◽

Cited By ~ 17

Author(s):

Shilong Xiong ◽

Xiaofan He ◽

Fayi Liu ◽

Jianzhong Han ◽

Juncheng Li ◽

...

Keyword(s):

Blood Coagulation ◽

Platelet Rich Plasma ◽

Critical Role ◽

Extrinsic Pathway ◽

Thrombin Inhibition ◽

Normal Plasma ◽

Low Concentrations ◽

Plasma Depletion ◽

Coagulation Pathway

SummaryBlood coagulation has been thought to be composed of both intrinsic and extrinsic pathways. Recent evidence strongly supports the critical role of the extrinsic pathway in the initiation of blood coagulation. This investigation established an assay that examines the role of FXI in the thromboplastin-initiated (extrinsic) coagulation based on this new concept. Plasma clotting times were measured at different concentrations of thromboplastin with activated FXII inhibited (FXIIa-inhibited Diluted Thromboplastin Time, FXIIaiDTT). Only at low concentrations of thromboplastin was FXIIaiDTT of FXI-deficient plasma significantly prolonged than that of normal plasma. Depletion of FXI from normal plasma prolonged its FXIIaiDTT and replenishment of FXI shortened it. FXIIaiDTTs of both FVIII-deficient and FIX-deficient plasma were remarkably prolonged, and addition of normal plasma dose-dependently shortened it. Furthermore, earlier α-thrombin inhibition was directly correlated with decreasing FXa generation. The amount of FXa production was: platelet-rich plasma > platelet-poor plasma > FXI-deficient plasma. Therefore, our findings from the FXIIaiDTT assays not only support the critical role of extrinsic pathway in blood coagulation initiation, but also demonstrate the importance of FXI as an amplifier of thrombin generation in thromboplastin-initiated coagulation.

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