Cytology and time of origin of interstitial neurons in the white matter in infant and adult human and monkey telencephalon

1980 ◽  
Vol 9 (2) ◽  
pp. 219-242 ◽  
Author(s):  
Ivica Kostovic ◽  
Pasko Rakic
Keyword(s):  
White Matter ◽  
Adult Human ◽  
Interstitial Neurons ◽  
Time Of Origin

scholarly journals White Matter Interstitial Neurons in the Adult Human Brain: 3% of Cortical Neurons in Quest for Recognition

Cells ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 190
Author(s):  
Goran Sedmak ◽  
Miloš Judaš
Keyword(s):  
Cerebral Cortex ◽  
White Matter ◽  
Human Brain ◽  
Cortical Neurons ◽  
Large Population ◽  
Adult Brain ◽  
Brain Disorders ◽  
Adult Human Brain ◽  
Adult Human ◽  
Interstitial Neurons

White matter interstitial neurons (WMIN) are a subset of cortical neurons located in the subcortical white matter. Although they were fist described over 150 years ago, they are still largely unexplored and often considered a small, functionally insignificant neuronal population. WMIN are adult remnants of neurons located in the transient fetal subplate zone (SP). Following development, some of the SP neurons undergo apoptosis, and the remaining neurons are incorporated in the adult white matter as WMIN. In the adult human brain, WMIN are quite a large population of neurons comprising at least 3% of all cortical neurons (between 600 and 1100 million neurons). They include many of the morphological neuronal types that can be found in the overlying cerebral cortex. Furthermore, the phenotypic and molecular diversity of WMIN is similar to that of the overlying cortical neurons, expressing many glutamatergic and GABAergic biomarkers. WMIN are often considered a functionally unimportant subset of neurons. However, upon closer inspection of the scientific literature, it has been shown that WMIN are integrated in the cortical circuitry and that they exhibit diverse electrophysiological properties, send and receive axons from the cortex, and have active synaptic contacts. Based on these data, we are able to enumerate some of the potential WMIN roles, such as the control of the cerebral blood flow, sleep regulation, and the control of information flow through the cerebral cortex. Also, there is a number of studies indicating the involvement of WMIN in the pathophysiology of many brain disorders such as epilepsy, schizophrenia, Alzheimer’s disease, etc. All of these data indicate that WMIN are a large population with an important function in the adult brain. Further investigation of WMIN could provide us with novel data crucial for an improved elucidation of the pathophysiology of many brain disorders. In this review, we provide an overview of the current WMIN literature, with an emphasis on studies conducted on the human brain.

Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain

10.1038/nm837 ◽  
2003 ◽  
Vol 9 (4) ◽  
pp. 439-447 ◽  
Author(s):  
Marta C. Nunes ◽  
Neeta Singh Roy ◽  
H. Michael Keyoung ◽  
Robert R. Goodman ◽  
Guy McKhann ◽  
...  
Keyword(s):  
White Matter ◽  
Human Brain ◽  
Progenitor Cells ◽  
Neural Progenitor Cells ◽  
Neural Progenitor ◽  
Subcortical White Matter ◽  
Adult Human Brain ◽  
Adult Human

Distribution of Microtubule-Associated Protein MAP2-Immunoreactive Interstitial Neurons in the Parahippocampal White Matter in Subjects With Schizophrenia

2003 ◽  
Vol 160 (1) ◽  
pp. 149-155 ◽  
Author(s):  
Lise Rioux ◽  
Jonathan Nissanov ◽  
Katherine Lauber ◽  
Warren B. Bilker ◽  
Steven E. Arnold
Keyword(s):  
White Matter ◽  
Interstitial Neurons

scholarly journals Populations of subplate and interstitial neurons in fetal and adult human telencephalon

2010 ◽  
Vol 217 (4) ◽  
pp. 381-399 ◽  
Author(s):  
Miloš Judaš ◽  
Goran Sedmak ◽  
Mihovil Pletikos ◽  
Nataša Jovanov-Milošević
Keyword(s):  
Adult Human ◽  
Interstitial Neurons ◽  
Human Telencephalon

Dynamic properties of learning-related grey and white matter changes in the adult human brain

2010 ◽  
Vol 41 (01) ◽  
Author(s):  
M Taubert ◽  
B Draganski ◽  
A Anwander ◽  
K Müller ◽  
A Horstmann ◽  
...  
Keyword(s):  
White Matter ◽  
Human Brain ◽  
Dynamic Properties ◽  
White Matter Changes ◽  
Adult Human Brain ◽  
Adult Human

Progenitor Cells of the Adult Human Subcortical White Matter

2004 ◽  
pp. 259-287 ◽  
Author(s):  
Neeta S. Roy ◽  
Martha S. Windrem ◽  
Steven A. Goldman
Keyword(s):  
White Matter ◽  
Progenitor Cells ◽  
Subcortical White Matter ◽  
Adult Human

scholarly journals InverseT2 contrast at 1.5 Tesla between gray matter and white matter in the occipital lobe of normal adult human brain

2001 ◽  
Vol 46 (2) ◽  
pp. 401-406 ◽  
Author(s):  
Jinyuan Zhou ◽  
Xavier Golay ◽  
Peter C.M. van Zijl ◽  
M. Johanna Silvennoinen ◽  
Risto Kauppinen ◽  
...  
Keyword(s):  
White Matter ◽  
Human Brain ◽  
Gray Matter ◽  
Occipital Lobe ◽  
Normal Adult ◽  
Adult Human Brain ◽  
Adult Human

Directed Growth of Adult Human White Matter Stem Cell–Derived Neurons on Aligned Fibrillar Collagen

2010 ◽  
Vol 16 (4) ◽  
pp. 1103-1113 ◽  
Author(s):  
Babette Lanfer ◽  
Andreas Hermann ◽  
Matthias Kirsch ◽  
Uwe Freudenberg ◽  
Ulrike Reuner ◽  
...  
Keyword(s):  
Stem Cell ◽  
White Matter ◽  
Fibrillar Collagen ◽  
Adult Human ◽  
Directed Growth
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