GABA-transaminase activity in rat and human brain: regional, age and sex-related differences

1991 ◽  
Vol 84 (1-2) ◽  
pp. 95-102 ◽  
Author(s):  
F. Sherif ◽  
L. Eriksson ◽  
L. Oreland
Keyword(s):  
Human Brain ◽  
Transaminase Activity ◽  
Gaba Transaminase ◽  
Age And Sex

scholarly journals Age and sex dependent variability of type 2 dopamine receptors in the human brain: A large-scale PET cohort

2021 ◽  
Author(s):  
Tuulia Malén ◽  
Tomi Karjalainen ◽  
Janne Isojärvi ◽  
Aki Vehtari ◽  
Paul-Christian Bürkner ◽  
...  
Keyword(s):  
Human Brain ◽  
Large Scale ◽  
Movement Control ◽  
Heterogeneous Data ◽  
Small Sample ◽  
Cross Sectional ◽  
Psychiatric Conditions ◽  
Small Sample Sizes ◽  
Age And Sex

BACKGROUND: The dopamine system contributes to a multitude of functions ranging from reward and motivation to learning and movement control, making it a key component in goal-directed behavior. Altered dopaminergic function is observed in neurological and psychiatric conditions. Numerous factors have been proposed to influence dopamine function, but due to small sample sizes and heterogeneous data analysis methods in previous studies their specific and joint contributions remain unresolved. METHODS: In this cross-sectional register-based study we investigated how age, sex, body mass index (BMI), as well as cerebral hemisphere and regional volume influence striatal type 2 dopamine receptor (D2R) availability in the human brain. We analyzed a large historical dataset (n=156, 120 males and 36 females) of [11C]raclopride PET scans performed between 2004 and 2018. RESULTS: Striatal D2R availability decreased through age for both sexes and was higher in females versus males throughout age. BMI and striatal D2R availability were weakly associated. There was no consistent lateralization of striatal D2R. The observed effects were independent of regional volumes. These results were validated using two different spatial normalization methods, and the age and sex effects also replicated in an independent sample (n=135). CONCLUSIONS: D2R density is dependent on age and sex, which may contribute to the vulnerability of neurological and psychiatric conditions involving altering D2R expression.

In vitro brain GABA-transaminase activity of 1-(4-acetylphenyl)-3-aryloxypyrrolidine-2,5-dione derivatives

2013 ◽  
Vol 6 (4) ◽  
pp. 442-446 ◽  
Author(s):  
Jigarkumar R. Patel ◽  
Bharat Z. Dholakiya ◽  
Nibha Mishra
Keyword(s):  
Transaminase Activity ◽  
Gaba Transaminase ◽  
Brain Gaba

Interleukin 1β and GABA-transaminase activity in rat thymus

2000 ◽  
Vol 22 (9) ◽  
pp. 719-728 ◽  
Author(s):  
D. Cavallotti ◽  
M. Artico ◽  
C. Cavallotti ◽  
S. De Santis ◽  
F.Tranquilli Leali
Keyword(s):  
Interleukin 1Β ◽  
Transaminase Activity ◽  
Gaba Transaminase

Reduced GABA transaminase activity in the Huntington's disease putamen

1984 ◽  
Vol 48 (3) ◽  
pp. 339-342 ◽  
Author(s):  
C.J. Carter
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Transaminase Activity ◽  
Gaba Transaminase

scholarly journals Role of nitric oxide synthase on brain GABA transaminase activity and GABA levels

2018 ◽  
Vol 68 (3) ◽  
pp. 349-359 ◽  
Author(s):  
Lourdes A. Vega Rasgado ◽  
Guillermo Ceballos Reyes ◽  
Fernando Vega Díaz
Keyword(s):  
Nitric Oxide ◽  
Ex Vivo ◽  
Transaminase Activity ◽  
Gaba Transaminase ◽  
Neuronal Nos ◽  
New Generation ◽  
Oxide Synthase ◽  
Brain Gaba

Abstract In an attempt to clarify the controversial role of nitric oxide (NO) in seizures, the effects of NO on brain GABA transaminase (GABA-T) activity and GABA levels were investigated. To this aim, the effects of the substrate (l-arginine) and inhibitors (Nω-nitro-l-arginine methyl ester, 7-nitroindazole) of NO synthase (NOS) on GABA-T activity and GABA levels in vitro and ex vivo were analyzed. In vitro NO diminished GABA-T activity and increased GABA. Ex vivo NO modified GABA-T activity and GABA levels biphasically. Inhibition of endothelial and neuronal NOS (eNOS and nNOS) had opposite effects on GABA-T activity and GABA levels, even during seizures induced by pentylenetetrazole. Different effects of NO on GABA-T activity and on GABA levels, depending on the NOS isoform involved, may explain its contradictory role in seizures, the endothelial NOS acting as an anticonvulsant and the neuronal NOS as a proconvulsant. nNOS inhibitors may represent a new generation of antiepileptics.

Effects of age and sex on the concentrations of glutamate and glutamine in the human brain

2013 ◽  
Vol 38 (6) ◽  
pp. 1480-1487 ◽  
Author(s):  
Sven Hädel ◽  
Christoph Wirth ◽  
Michael Rapp ◽  
Jürgen Gallinat ◽  
Florian Schubert
Keyword(s):  
Human Brain ◽  
Age And Sex

Proton spectroscopy of human brain: Effects of age and sex

1994 ◽  
Vol 18 (6) ◽  
pp. 995-1004 ◽  
Author(s):  
H.Cecil Charles ◽  
Francois Lazeyras ◽  
K.Ranga Rama Krishnan ◽  
Orest B. Boyko ◽  
Linda J. Patterson ◽  
...  
Keyword(s):  
Human Brain ◽  
Proton Spectroscopy ◽  
Age And Sex

In Vivo Measurement of Dopamine Receptors in Human Brain by Positron Emission Tomography Age and Sex Differences

1988 ◽  
Vol 515 (1 Central Deter) ◽  
pp. 203-214 ◽  
Author(s):  
DEAN F. WONG ◽  
EMMANUEL P. BROUSSOLLE ◽  
GARY WAND ◽  
VICTOR VILLEMAGNE ◽  
ROBERT F. DANNALS ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Sex Differences ◽  
Human Brain ◽  
Dopamine Receptors ◽  
Emission Tomography ◽  
In Vivo Measurement ◽  
Positron Emission ◽  
Age And Sex

Effects of the antidepressant/antipanic drug phenelzine on GABA concentrations and GABA-transaminase activity in rat brain

1992 ◽  
Vol 43 (11) ◽  
pp. 2486-2489 ◽  
Author(s):  
David J. McManus ◽  
Glen B. Baker ◽  
Ian L. Martin ◽  
Andrew J. Greenshaw ◽  
Kevin F. McKenna
Keyword(s):  
Rat Brain ◽  
Transaminase Activity ◽  
Gaba Transaminase
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