Adrenergic, serotoninergic, histaminergic, and imipramine binding sites in post-mortal human cerebral microvessel preparations

1988 ◽  
Vol 73 (3) ◽  
pp. 177-189 ◽  
Author(s):  
C. O'Neill ◽  
C. J. Fowler ◽  
J. O. Marcusson ◽  
B. Winblad
Keyword(s):  
Binding Sites ◽  
Imipramine Binding ◽  
Cerebral Microvessel

Tritiated imipramine binding sites in affective disorders and schizophrenia

1987 ◽  
Vol 12 (3) ◽  
pp. 193-198 ◽  
Author(s):  
D.H. Desmedt ◽  
D. Egrise ◽  
J. Mendlewicz
Keyword(s):  
Binding Sites ◽  
Affective Disorders ◽  
Imipramine Binding

scholarly journals Imipramine Binding Sites in Membrane Preparations from Monkey Brain

1988 ◽  
Vol 46 ◽  
pp. 236
Author(s):  
Ritsuko Takano ◽  
Toru Egashira ◽  
Yasumitsu Yamanaka
Keyword(s):  
Binding Sites ◽  
Monkey Brain ◽  
Imipramine Binding

Platelet 3H-imipramine binding in major depressive episodes

1991 ◽  
Vol 6 (2) ◽  
pp. 73-78
Author(s):  
G Faludi ◽  
K Tekes
Keyword(s):  
Clinical Practice ◽  
Binding Sites ◽  
Biological Marker ◽  
Affinity Constant ◽  
Major Depressive ◽  
State Dependent ◽  
Imipramine Binding ◽  
Major Depressive Episodes ◽  
Depressive Episodes ◽  
Age And Sex

SummaryDensity (Bmax) and affinity constant (Kd) values of tritiated imipramine binding sites were determined on platelets from patients suffering from major depression and from healthy, age-and sex-matched controls. Significantly lower Bmax values were found in the depressed patients, while the Kd values did not differ from those of controls. The results suggest that, in accordance with data from the literature, decrease in 3H-imipramine binding sites may be used as a state-dependent biological marker of depression in clinical practice.

Chemical heterogeneity of [3H]imipramine binding sites on human platelet membranes

1990 ◽  
Vol 189 (2-3) ◽  
pp. 175-183
Author(s):  
Andrey M. Fomenko ◽  
Yury G. Plyashkevich ◽  
Oleg S. Brusov ◽  
Vladimir P. Demushkin
Keyword(s):  
Binding Sites ◽  
Human Platelet ◽  
Chemical Heterogeneity ◽  
Platelet Membranes ◽  
Imipramine Binding

Pre- and Postsynaptic Localization of3H-Imipramine Binding Sites in Rat Cerebral Cortex

1984 ◽  
Vol 4 (7) ◽  
pp. 755-771 ◽  
Author(s):  
Marta Stockert ◽  
Angela Veiga ◽  
Sergio Butman ◽  
Eduardo De Robertis
Keyword(s):  
Cerebral Cortex ◽  
Binding Sites ◽  
Rat Cerebral Cortex ◽  
Imipramine Binding

3H-imipramine binding sites in the rat brain

1981 ◽  
Vol 317 (4) ◽  
pp. 310-314 ◽  
Author(s):  
G. Gro� ◽  
M. G�thert ◽  
H.-P. Ender ◽  
H.-J. Sch�mann
Keyword(s):  
Rat Brain ◽  
Binding Sites ◽  
Imipramine Binding

Decreased Imipramine Binding in the Brains of Patients with Depressive Illness

1983 ◽  
Vol 142 (2) ◽  
pp. 188-192 ◽  
Author(s):  
E. K. Perry ◽  
E. F. Marshall ◽  
G. Blessed ◽  
B. E. Tomlinson ◽  
R. H. Perry
Keyword(s):  
Psychiatric Disorder ◽  
Binding Sites ◽  
Senile Dementia ◽  
Occipital Cortex ◽  
Depressive Illness ◽  
Scatchard Analysis ◽  
Alzheimer Type ◽  
Dementia Of Alzheimer Type ◽  
Uptake Mechanism ◽  
Imipramine Binding

SummaryThe binding of tritiated imipramine was significantly reduced in the hippocampus and occipital cortex from a series of patients with depressive illness compared with age-matched patients with no psychiatric disorder. In contrast there was no change in imipramine binding in established cases of senile dementia of Alzheimer-type. Scatchard analysis indicated normal binding affinity but a reduction in the number of imipramine binding sites in depression. These observations parallel previous findings of decreased binding sites in platelets from depressed patients and suggest there may be an abnormality in the uptake mechanism for serotonin in depression.

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