Diagnostic value of serum bile acids and routine liver function tests in hepatobiliary diseases

1983 ◽  
Vol 28 (2) ◽  
pp. 129-136 ◽  
Author(s):  
R. Ferraris ◽  
G. Colombatti ◽  
M. T. Fiorentini ◽  
R. Carosso ◽  
W. Arossa ◽  
...  
Keyword(s):  
Liver Function ◽  
Bile Acids ◽  
Liver Function Tests ◽  
Diagnostic Value ◽  
Serum Bile Acids ◽  
Function Tests ◽  
Hepatobiliary Diseases

scholarly journals Obstetric Cholestasis: A Review and Update

2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Olawumi Adaramodu ◽  
Anthony Kodzo-Grey Venyo
Keyword(s):  
Liver Function ◽  
Bile Acids ◽  
Intrahepatic Cholestasis ◽  
Liver Function Tests ◽  
Intrahepatic Cholestasis Of Pregnancy ◽  
Third Trimester ◽  
Serum Bile Acids ◽  
Function Tests ◽  
Cholestasis Of Pregnancy ◽  
In Pregnancy

Obstetric cholestasis (OC) is a liver disorder that occurs in the late second and early third trimester of pregnancy characterized by pruritus with increased serum bile acids and other liver function tests. The pathophysiology of OC is still not completely understood. The symptoms and biochemical abnormality rapidly resolve after delivery. OC is associated with an increased risk of adverse obstetrical outcomes. The aetiology of obstetric cholestasis of pregnancy is poorly understood and is thought to be complicated and multifactorial.  OC typically occurs in the late second trimester when the oestrogen levels are the highest in pregnancy. The most common complaint is generalized intense pruritus, which usually starts after the 30th week of pregnancy. Pruritus can be more common in the palms and soles and is typically worse at night. Other symptoms of cholestasis, such as nausea, anorexia, fatigue, right upper quadrant pain, dark urine, and pale stool, can be present. Clinical jaundice is rare but may present in 14% to 25% of patients after 1 to 4 weeks of the onset of pruritus. Some patients also complain of insomnia as a result of pruritus. Generally, physical examination is unremarkable except for scratch marks on the skin from pruritus. Pruritus is a cardinal symptom of intra-hepatic cholestasis of pregnancy (ICP) and may precede biochemical abnormalities. The diagnosis of intrahepatic cholestasis of pregnancy is via the presence of clinical symptoms pruritus in the third trimester with elevated maternal total serum bile acids and excluding other diagnoses, which can cause similar symptoms and lab abnormalities. Fasting blood samples should be used to check for the total bile salt acid level as it can become elevated in the postprandial state. Once the diagnosis of OC of pregnancy is confirmed, immediate treatment is necessary, and the primary goal of therapy is to decrease the risk of perinatal morbidity and mortality and to alleviate maternal symptoms. Maternal pruritus can be alleviated with use of moisturisers and oral antihistamines. Ursodeoxycholic acid (UDCA) is the drug of choice for the treatment of ICP. Many authors have advocated elective early delivery of women with intrahepatic cholestasis of pregnancy to reduce the risk of sudden foetal death. The Royal College of Obstetricians and Gynaecologists recommends induction of labour after 37+0 weeks of gestation. Obstetric cholestasis of pregnancy is not an indication for Caesarean delivery. Postpartum pruritus typically disappears in the first 2 to 3 days following delivery, and serum bile acid concentrations will normalize eventually. ICP is not a contraindication to breastfeeding, and mothers with a history of ICP in pregnancy can breastfeed their infants. Postpartum monitoring and follow up of bile acids and liver function tests should be done in 4-6 weeks to ensure resolution. Women with the persistent abnormality of liver function test after 6 to 8 weeks require investigation for other aetiologies.

LIVER DAMAGE AFTER PARACETAMOL OVERDOSE COMPARISON OF LIVER-FUNCTION TESTS, FASTING SERUM BILE ACIDS, AND LIVER HISTOLOGY

The Lancet ◽  
1975 ◽  
Vol 306 (7935) ◽  
pp. 579-581 ◽  
Author(s):  
Oliver James ◽  
S.H. Roberts ◽  
AdrianP. Douglas ◽  
M. Lesna ◽  
L. Pulman ◽  
...  
Keyword(s):  
Liver Function ◽  
Bile Acids ◽  
Liver Damage ◽  
Liver Function Tests ◽  
Liver Histology ◽  
Paracetamol Overdose ◽  
Fasting Serum ◽  
Serum Bile Acids ◽  
Function Tests

Serum Bile Acids, Gamma-Glutamyltransferase and Routine Liver Function Tests in Emetic and Nonemetic Pregnancies

1986 ◽  
Vol 21 (4) ◽  
pp. 169-176 ◽  
Author(s):  
A. Järnfelt-Samsioe ◽  
B. Eriksson ◽  
J. Waldenström ◽  
G. Samsioe
Keyword(s):  
Liver Function ◽  
Bile Acids ◽  
Liver Function Tests ◽  
Gamma Glutamyltransferase ◽  
Serum Bile Acids ◽  
Function Tests

Diagnostic Effectiveness of Biochemical Liver-Function Tests, as Evaluated by Discriminant Function Analysis

1977 ◽  
Vol 23 (4) ◽  
pp. 627-630 ◽  
Author(s):  
Paul Phillip Sher
Keyword(s):  
Alkaline Phosphatase ◽  
Lactate Dehydrogenase ◽  
Discriminant Analysis ◽  
Liver Function ◽  
Function Analysis ◽  
Liver Function Tests ◽  
Diagnostic Value ◽  
Hepatic Disease ◽  
Stepwise Discriminant Analysis ◽  
Function Tests

Abstract I evaluated the diagnostic value of routinely ordered liver-function tests in 175 biopsy-proven cases of hepatic disease by use of stepwise discriminant analysis. The tests studied—total and "direct" bilirubin, alkaline phosphatase, lactate dehydrogenase, and aspartate aminotrans-ferase—correctly classified 45-73% of cases, depending on the homogeneity of the diagnostic groups. Aspartate aminotransferase and alkaline phosphatase were the best discriminators. When all tests were used in the most ho-mogeneous groups (tumors, cirrhosis, and hepatitis), there was a stepwise improvement in diagnostic accuracy from 51 to 73%.

scholarly journals Diagnostic value of liver function tests and Entamoeba histolytica antibody studies in East Africans

1967 ◽  
Vol 20 (2) ◽  
pp. 180-184 ◽  
Author(s):  
D. P. Mullan ◽  
A. M. Ward ◽  
S. Shah ◽  
A. L. Jeanes
Keyword(s):  
Liver Function ◽  
Entamoeba Histolytica ◽  
Liver Function Tests ◽  
Diagnostic Value ◽  
Function Tests

scholarly journals Performance of a calculator for diagnosing the cause of liver damage

2019 ◽  
Vol 147 (1-2) ◽  
pp. 27-33
Author(s):  
Narcisa Petrovic-Subic ◽  
Miroslav Kojic ◽  
Slobodan Jankovic ◽  
Srdjan Stefanovic
Keyword(s):  
Liver Function ◽  
Liver Damage ◽  
Real Life ◽  
High Specificity ◽  
Liver Function Tests ◽  
Diagnostic Value ◽  
Abnormal Liver Function ◽  
Function Tests ◽  
Good Ability ◽  
Significant Difference

Introduction/Objective. Making a calculator that would recognize patterns of abnormal liver function tests and link them to the most probable etiology could help clinicians in their initial orientation towards a definitive diagnosis in patients with liver damage. The aim of our study was to design, construct, and validate a calculator that based on a pattern of abnormalities in liver function tests of a patient with liver damage would propose the most probable etiology. Methods. Patterns of abnormal liver function tests for certain etiology of liver damage were extracted from distributions of actual values taken from reports in medical literature about patients whose etiology of liver damage was proven by reliable diagnostic tests. After setting up the calculator with the patterns extracted, its diagnostic value was checked under real-life conditions, on a sample of patients with liver damage whose etiology was established by the gold standard of diagnostics (biopsy or else). The calculator validation study was carried out at the Military Medical Academy in Belgrade during a two-year period (2015?2016). Results. For all tested diagnoses, the calculator demonstrated a highly significant difference between the area under the receiver-operator curves? values and the value of 0.5 (p < 0.001), and high level of sensitivity (more than 90%, except for the model for chronic hepatitis) as well as relatively high specificity (more than 75%) were noted, indicating good ability of the calculator to detect etiology of liver damage. Conclusion. New calculators showed satisfactory sensitivity and specificity for revealing major liver damage etiologies.

Diagnostic value of liver function tests in bile duct obstruction

1989 ◽  
Vol 46 (3) ◽  
pp. 226-229 ◽  
Author(s):  
Theodore A. Stein ◽  
Gerard P. Burns ◽  
Leslie Wise
Keyword(s):  
Bile Duct ◽  
Liver Function ◽  
Liver Function Tests ◽  
Diagnostic Value ◽  
Bile Duct Obstruction ◽  
Duct Obstruction ◽  
Function Tests

scholarly journals Diagnostic value of liver function tests in the detection of hepatic metastases in lung cancer patients.

Haigan ◽  
1985 ◽  
Vol 25 (5) ◽  
pp. 609-615
Author(s):  
Hiroshi Nishio ◽  
Takahiko Sakuma ◽  
Shinichiro Nakamura ◽  
Takeshi Horai ◽  
Harumichi Ikegami ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Liver Function ◽  
Cancer Patients ◽  
Hepatic Metastases ◽  
Liver Function Tests ◽  
Diagnostic Value ◽  
Lung Cancer Patients ◽  
Function Tests

An Evaluation of Factors Influencing the Discriminative Effectiveness of a Group of Liver Function Tests

1955 ◽  
Vol 28 (6) ◽  
pp. 914-926 ◽  
Author(s):  
Leslie Zieve ◽  
Earl Hill
Keyword(s):  
Liver Function ◽  
Liver Function Tests ◽  
Factors Influencing ◽  
Function Tests
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