The acute effect of nimodipine on cerebral blood flow, its CO2 reactivity, and cerebral oxygen metabolism in human volunteers

1991 ◽  
Vol 111 (1-2) ◽  
pp. 49-53 ◽  
Author(s):  
J. F. Schmidt ◽  
G. Waldemar ◽  
O. B. Paulson
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Oxygen Metabolism ◽  
Acute Effect ◽  
Cerebral Oxygen ◽  
Co2 Reactivity ◽  
Cerebral Oxygen Metabolism ◽  
Human Volunteers

scholarly journals Sustained high-altitude hypoxia increases cerebral oxygen metabolism

2013 ◽  
Vol 114 (1) ◽  
pp. 11-18 ◽  
Author(s):  
Zachary M. Smith ◽  
Erin Krizay ◽  
Jia Guo ◽  
David D. Shin ◽  
Miriam Scadeng ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
High Altitude ◽  
Acute Mountain Sickness ◽  
Oxygen Metabolism ◽  
Cerebral Oxygen ◽  
Altitude Hypoxia ◽  
Cerebral Oxygen Metabolism ◽  
High Altitude Hypoxia ◽  
Significant Difference

Acute mountain sickness (AMS) is a common condition occurring within hours of rapid exposure to high altitude. Despite its frequent occurrence, the pathophysiological mechanisms that underlie the condition remain poorly understood. We investigated the role of cerebral oxygen metabolism (CMRO2) in AMS. The purpose of this study was to test 1) if CMRO2 changes in response to hypoxia, and 2) if there is a difference in how individuals adapt to oxygen metabolic changes that may determine who develops AMS and who does not. Twenty-six normal human subjects were recruited into two groups based on Lake Louise AMS score (LLS): those with no AMS (LLS ≤ 2), and those with unambiguous AMS (LLS ≥ 5). [Subjects with intermediate scores (LLS 3–4) were not included.] CMRO2 was calculated from cerebral blood flow and arterial-venous difference in O2 content. Cerebral blood flow was measured using arterial spin labeling MRI; venous O2 saturation was calculated from the MRI of transverse relaxation in the superior sagittal sinus. Arterial O2 saturation was measured via pulse oximeter. Measurements were made during normoxia and after 2-day high-altitude exposure at 3,800 m. In all subjects, CMRO2 increased with sustained high-altitude hypoxia [1.54 (0.37) to 1.82 (0.49) μmol·g−1·min−1, n = 26, P = 0.045]. There was no significant difference in CMRO2 between AMS and no-AMS groups. End-tidal Pco2 was significantly reduced during hypoxia. Low arterial Pco2 is known to increase neural excitability, and we hypothesize that the low arterial Pco2 resulting from ventilatory acclimatization causes the observed increase in CMRO2.

scholarly journals Effect of Extracorporeal Membrane Oxygenation on Cerebral Blood Flow and Cerebral Oxygen Metabolism in Newborn Sheep

1990 ◽  
Vol 28 (1) ◽  
pp. 50-51 ◽  
Author(s):  
Billie Lou Short ◽  
L Kyle Walker ◽  
Christine A Gleason ◽  
M Douglas Jones ◽  
Richard J Traystman
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Extracorporeal Membrane Oxygenation ◽  
Oxygen Metabolism ◽  
Cerebral Oxygen ◽  
Cerebral Oxygen Metabolism ◽  
Membrane Oxygenation

Cerebral oxygen metabolism and cerebral blood flow in man during light sleep (stage 2)

1991 ◽  
Vol 557 (1-2) ◽  
pp. 217-220 ◽  
Author(s):  
Peter Lund Madsen ◽  
Jes F. Schmidt ◽  
Søren Holm ◽  
Sissel Vorstrup ◽  
Niels A. Lassen ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Sleep Stage ◽  
Oxygen Metabolism ◽  
Cerebral Oxygen ◽  
Cerebral Oxygen Metabolism ◽  
Light Sleep

Abstract 17303: Longitudinal Cerebral Oxygen Metabolism in Congenital Heart Disease

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Jessie Mei Lim ◽  
Davide Marini ◽  
Amandeep Saini ◽  
Stephanie Au-Young ◽  
Steven Fan ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Oxygen Consumption ◽  
Congenital Heart ◽  
Oxygen Metabolism ◽  
Cerebral Oxygen ◽  
Brain Growth ◽  
Cerebral Oxygen Metabolism ◽  
Cerebral Oxygen Consumption

Background: Brain growth differences are apparent between different types of cyanotic congenital heart disease, but the underlying mechanism remains unclear. Here, we explored and characterized longitudinal cerebral hemodynamic and oxygen metabolism profiles and their relationships to brain growth patterns in infants with single ventricle physiologies (SV) and transposition of the great arteries (TGA). We hypothesized that there are marked differences in cerebral oxygen metabolism in those with SV compared with TGA. Methods: Cerebral blood flow (CBF), oxygen delivery (CDO2) and consumption (CVO2) and brain growth were measured in 103 term newborns with SV and TGA using MRI at pre- and post-surgery and at follow-up. We measured whole brain size by segmenting a 3D steady state free precession acquisition. Cerebral blood flow was measured using phase contrast imaging of the neck vessels and cerebral venous blood oxygen saturation was derived from T2 oximetry of the superior sagittal sinus. TGAs were divided into those with and without ventricular septums. Results: CBF profiles were similar between the 3 lesion groups. Cerebral oxygen delivery trends increased but were not significantly different between cardiac groups. We observed that this may be mediated by different mechanisms: an increase in arterial saturation in TGAs, and an increase in hemoglobin concentration in SVs. Cerebral oxygen consumption in SV infants remained low (p = 0.54) while that of TGA increased over time (TGA IVS p < 0.001; TGA VSD p <0.001) (Fig. 1), mediated by an unchanging oxygen extraction fraction in SVs (p = 0.59). The SV cerebral oxygen consumption profile aligned with their declining brain weight z-score trajectory. Conclusions: In conclusion, there are characteristic differences in hemodynamic adaptations between SVs and TGAs. Changes in oxygen metabolism may be facilitating brain growth trajectories. This informs us of possible mechanisms involved during a time of critical brain development.

Correlation Between Cerebral Oxygen Metabolism and Cerebral Blood Flow Simultaneously Measured Before and After Acetazolamide Administration

1999 ◽  
Vol 4 (4) ◽  
pp. 418 ◽  
Author(s):  
Hiroichiro Yamaguchi ◽  
Hideto Yamauchi ◽  
Shiro Hazama ◽  
Hirotsugu Hamamoto ◽  
Nobuhiro Inoue
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Oxygen Metabolism ◽  
Cerebral Oxygen ◽  
Cerebral Oxygen Metabolism ◽  
Before And After
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