Management of acute colitis in inflammatory bowel disease

1986 ◽  
Vol 10 (5) ◽  
pp. 814-818 ◽  
Author(s):  
P. Morel ◽  
P. C. Hawker ◽  
R. N. Allan ◽  
P. W. Dykes ◽  
J. Alexander-Williams
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Acute Colitis ◽  
Inflammatory Bowel

Endothelial hyaluronan synthase 3 aggravates acute colitis in an experimental model of inflammatory bowel disease

2021 ◽  
Author(s):  
Christian Hundhausen ◽  
Rebekka Schneckmann ◽  
Yanina Ostendorf ◽  
Jacqueline Rimpler ◽  
Anette von Glinski ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Experimental Model ◽  
Bowel Disease ◽  
Hyaluronan Synthase ◽  
Acute Colitis ◽  
Inflammatory Bowel

Is abdominal CT useful for the management of patients with severe acute colitis complicating inflammatory bowel disease? A study in 54 consecutive patients

2017 ◽  
Vol 19 (4) ◽  
pp. O97-O102 ◽  
Author(s):  
D. Mege ◽  
M. Monsinjon ◽  
M. Zappa ◽  
C. Stefanescu ◽  
X. Treton ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Acute Colitis ◽  
Abdominal Ct ◽  
Severe Acute Colitis ◽  
Inflammatory Bowel

P461 Is laparoscopy safe and useful in patients with acute colitis complicating inflammatory bowel disease? A first meta-analysis in 478 patients

2013 ◽  
Vol 7 ◽  
pp. S194
Author(s):  
L. Maggiori ◽  
A. Khayat ◽  
X. Tréton ◽  
F. Bretagnol ◽  
Y. Bouhnik ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Meta Analysis ◽  
Acute Colitis ◽  
Inflammatory Bowel

Laparoscopic-assisted vs open colectomy for severe acute colitis in patients with inflammatory bowel disease (IBD)

2000 ◽  
Vol 14 (10) ◽  
pp. 911-914 ◽  
Author(s):  
M. S. Dunker ◽  
W. A. Bemelman ◽  
J. F. M. Slors ◽  
R. A. van Hogezand ◽  
J. Ringers ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Open Colectomy ◽  
Acute Colitis ◽  
Severe Acute Colitis ◽  
Inflammatory Bowel ◽  
Laparoscopic Assisted

New probiotic strains for inflammatory bowel disease management identified by combining in vitro and in vivo approaches

2018 ◽  
Vol 9 (2) ◽  
pp. 317-331 ◽  
Author(s):  
J. Alard ◽  
V. Peucelle ◽  
D. Boutillier ◽  
J. Breton ◽  
S. Kuylle ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Inflammatory Diseases ◽  
Chronic Colitis ◽  
Acute Colitis ◽  
Probiotic Strains ◽  
Inflammatory Bowel ◽  
Anti Inflammatory

Alterations in the gut microbiota composition play a key role in the development of chronic diseases such as inflammatory bowel disease (IBD). The potential use of probiotics therefore gained attention, although outcomes were sometimes conflicting and results largely strain-dependent. The present study aimed to identify new probiotic strains that have a high potential for the management of this type of pathologies. Strains were selected from a large collection by combining different in vitro and in vivo approaches, addressing both anti-inflammatory potential and ability to improve the gut barrier function. We identified six strains with an interesting anti-inflammatory profile on peripheral blood mononuclear cells and with the ability to restore the gut barrier using a gut permeability model based on Caco-2 cells sensitized with hydrogen peroxide. The in vivo evaluation in two 2,4,6-trinitrobenzene sulfonic acid-induced murine models of colitis highlighted that some of the strains exhibited beneficial activities against acute colitis while others improved chronic colitis. Bifidobacterium bifidum PI22, the strain that exhibited the most protective capacities against acute colitis was only slightly efficacious against chronic colitis, while Bifidobacterium lactis LA804 which was less efficacious in the acute model was the most protective against chronic colitis. Lactobacillus helveticus PI5 was not anti-inflammatory in vitro but the best in strengthening the epithelial barrier and as such able to significantly dampen murine acute colitis. Interestingly, Lactobacillus salivarius LA307 protected mice significantly against both types of colitis. This work provides crucial clues for selecting the best strains for more efficacious therapeutic approaches in the management of chronic inflammatory diseases. The strategy employed allowed us to identify four strains with different characteristics and a high potential for the management of inflammatory diseases, such as IBD.

scholarly journals P227 Timing of acute severe colitis in the course of an inflammatory bowel disease: is it a prognostic factor?

2021 ◽  
Vol 15 (Supplement_1) ◽  
pp. S278-S278
Author(s):  
N Sahar ◽  
W Dahmani ◽  
E Nour ◽  
H Aya ◽  
B A Wafa ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Clinical Presentation ◽  
Response To Therapy ◽  
Full Blood Count ◽  
Acute Colitis ◽  
Severe Acute Colitis ◽  
Group A ◽  
Inflammatory Bowel ◽  
Group B

Abstract Background In this study, we aimed to compare outcomes of patients with a severe acute colitis (SAC) inaugurating their inflammatory bowel disease (IBD) with SAC occurring in those with Known diagnosis of IBD. Methods We conducted a retrospective chart review of patients who were admitted to our unit for severe acute colitis over 7 years. Demographics, characteristics of the disease, clinical presentation, laboratory, morphologic investigations, treatments and outcomes were reviewed from medical records. Patients were divided in two groups: SAC inaugurating IBD (A) and SAC occurring during the course of Known IBD (B) and compared in terms of clinical presentation, response to medical treatment and colectomy rate. Statistical analysis was performed with SPSS software version 19. Results A total of 62 patients were colliged (23 males and 39 females). Mean age at the onset of SAC was 36 years (14–78 years). There were 34 patients of group (A) and 28 patients of group (B). Overall, there were 28 patients with Crohn’s disease, 31 patients with UC and 3 others with indetermined colitis. There were no differences between both of the groups with regard to sex, age at the onset of SAC, smoking status, family history of IBD, body mass index and laboratory findings including full blood count and C reactive protein. Mean Truelove–Witts score was higher in group A vs group B (4 Vs 3, p<0.0001). Erythrocyte sedimentation rate was slightly higher in group A than group B (68 Vs 53, p=0.07). Overall, endoscopic signs of severity were significantly more common in patients from group A vs group B: deep colonic ulcerations (p=0.05) and diffuse mucosal abrasions (p=0.04). Patients from group B seem to respond better to steroid therapy than patients from group A (68% Vs 58%, p=0.5). There was no difference between both of the groups with regard to use of cyclosporine, colectomy, and recurrence of SAC. Conclusion Patients with severe acute colitis inaugurating their IBD seemed to have more severe clinical presentation than in those followed for IBD and complicated by SAC. However, response to therapy and need for colectomy are similar in both groups.

scholarly journals P540 Can we predict response to cyclosporine as second line therapy in patients with severe acute colitis of inflammatory bowel disease?

2014 ◽  
Vol 8 ◽  
pp. S292-S293
Author(s):  
N. Ben Mustapha ◽  
A. Labidi ◽  
M. Serghini ◽  
H. Dabbabi ◽  
M. Fekih ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Second Line ◽  
Acute Colitis ◽  
Second Line Therapy ◽  
Line Therapy ◽  
Severe Acute Colitis ◽  
Inflammatory Bowel
Sign in / Sign up

Export Citation Format

Share Document