scholarly journals P142 Postoperative course of laparoscopic subtotal colectomy is not affected by preoperative medical treatment in patients with acute colitis complicating inflammatory bowel disease

2017 ◽  
Vol 11 (suppl_1) ◽  
pp. S148-S148
Author(s):  
D. Mege ◽  
M. Monsinjon ◽  
L. Maggiori ◽  
X. Tréton ◽  
Y. Bouhnik ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Medical Treatment ◽  
Bowel Disease ◽  
Subtotal Colectomy ◽  
Acute Colitis ◽  
Postoperative Course ◽  
Laparoscopic Subtotal Colectomy ◽  
Inflammatory Bowel

Management of Rectal Stump During Laparoscopic Subtotal Colectomy for Inflammatory Bowel Disease: A Comparative Cohort Study from Six Referral Centres

2020 ◽  
Vol 14 (9) ◽  
pp. 1214-1221 ◽  
Author(s):  
Diane Mege ◽  
Merel E Stellingwerf ◽  
Adeline Germain ◽  
Francesco Colombo ◽  
Gianluca Pellino ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Subtotal Colectomy ◽  
Rectal Stump ◽  
Best Management ◽  
Comparative Cohort Study ◽  
Laparoscopic Subtotal Colectomy ◽  
Inflammatory Bowel ◽  
The Impact ◽  
Retrospective Database

Abstract Background and Aims There is no consensus on the best management of the rectum after subtotal colectomy for refractory colitis complicating inflammatory bowel disease [IBD]. The objective was to evaluate the impact of rectal stump management during laparoscopic subtotal colectomy [LSTC] for IBD. Methods Patients who underwent LSTC with double-end ileo-sigmoidostomy [Gr.A] or end ileostomy with closed rectal stump [Gr.B] for IBD were included from a retrospective database of six European referral centres. Results In total, 314 patients underwent LSTC and were allocated to Gr.A [n = 102] and B [n = 212]. After LSTC, stoma-related complications occurred more frequently in Gr.A [12%] than in Gr.B [4%, p = 0.01]. Completion proctectomy with ileal pouch-anal anastomosis [IPAA] was performed as a three-stage procedure in all patients from Gr.A, and in 88 patients from Gr.B [42%; Gr.B1]. The other 124 patients from Gr.B underwent a modified two-stage procedure [58%; Gr.B2]. The second stage was performed laparoscopically in all patients from Gr.A compared with 73% of Gr.B1 [p < 0.0001] and 65% of Gr.B2 patients [p < 0.0001]. When laparoscopy was intended for 2nd stage IPAA, conversion to laparotomy occurred less frequently in Gr.A when compared with B1 [0 vs 5%, p = 0.06] or B2 [10%, p = 0.001]. When all surgical stages were included [LSCT and IPAA], cumulative stoma-related complications occurred more frequently in Gr.A [n = 19] than in Gr.B1 [n = 6, p = 0.02] and Gr.B2 [n = 6, p = 0.001]. Conclusion This study suggests that both techniques of double-end ileosigmoidostomy and end ileostomy with closed rectal stump are safe and effective for rectal stump management after laparoscopic subtotal colectomy.

Laparoscopic subtotal colectomy for acute or severe colitis complicating inflammatory bowel disease: A case-matched study in 88 patients

Surgery ◽  
2007 ◽  
Vol 141 (5) ◽  
pp. 640-644 ◽  
Author(s):  
Cécile Marceau ◽  
Arnaud Alves ◽  
Mehdi Ouaissi ◽  
Yoram Bouhnik ◽  
Patrice Valleur ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Subtotal Colectomy ◽  
Laparoscopic Subtotal Colectomy ◽  
Inflammatory Bowel ◽  
Matched Study ◽  
Severe Colitis

Endothelial hyaluronan synthase 3 aggravates acute colitis in an experimental model of inflammatory bowel disease

2021 ◽  
Author(s):  
Christian Hundhausen ◽  
Rebekka Schneckmann ◽  
Yanina Ostendorf ◽  
Jacqueline Rimpler ◽  
Anette von Glinski ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Experimental Model ◽  
Bowel Disease ◽  
Hyaluronan Synthase ◽  
Acute Colitis ◽  
Inflammatory Bowel

Medical treatment of inflammatory bowel disease

1992 ◽  
Vol 8 (4) ◽  
pp. 663-675 ◽  
Author(s):  
M Campieri ◽  
P Gionchetti ◽  
A Belluzzi ◽  
C Brignola ◽  
M Miglioli ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Medical Treatment ◽  
Bowel Disease ◽  
Inflammatory Bowel

scholarly journals Incisional hernia repair by synthetic mesh prosthesis in patients with inflammatory bowel disease: a comparative analysis

BMC Surgery ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Daniel Heise ◽  
Charles Schram ◽  
Roman Eickhoff ◽  
Jan Bednarsch ◽  
Marius Helmedag ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Risk Factor ◽  
Hernia Repair ◽  
Bowel Disease ◽  
Hernia Recurrence ◽  
Postoperative Course ◽  
Major Complications ◽  
Inflammatory Bowel ◽  
The Impact

Abstract Background Patients with inflammatory bowel disease (IBD) have a high-life time risk undergoing abdominal surgery and are prone to develop incisional hernias (IH) in the postoperative course. Therefore, we investigated the role of IBD as perioperative risk factor in open ventral hernia repair (OVHR) as well as the impact of IBD on hernia recurrence during postoperative follow-up. Methods The postoperative course of 223 patients (Non-IBD (n = 199) and IBD (n = 34)) who underwent OVHR were compared by means of extensive group comparisons and binary logistic regressions. Hernia recurrence was investigated in the IBD group according to the Kaplan–Meier method and risk factors for recurrence determined by Cox regressions. Results General complications (≥ Clavien-Dindo I) occurred in 30.9% (72/233) and major complications (≥ Clavien-Dindo IIIb) in 7.7% (18/233) of the overall cohort with IBD being the single independent risk-factor for major complications (OR = 4.2, p = 0.007). Further, IBD patients displayed a recurrence rate of 26.5% (9/34) after a median follow-up of 36 months. Multivariable analysis revealed higher rates of recurrence in patients with ulcerative colitis (UC, 8/15, HR = 11.7) compared to patients with Crohn’s disease (CD, 1/19, HR = 1.0, p = 0.021). Conclusion IBD is a significant risk factor for major postoperative morbidity after OVHR. In addition, individuals with IBD show high rates of hernia recurrence over time with UC patients being more prone to recurrence than patients with CD.

scholarly journals P501 Incidence and therapeutic management/treatment of very early onset inflammatory bowel disease during 2015–2020

2021 ◽  
Vol 15 (Supplement_1) ◽  
pp. S485-S485
Author(s):  
G Ninh ◽  
V Wewer ◽  
C Jakobsen
Keyword(s):  
Inflammatory Bowel Disease ◽  
Surgical Treatment ◽  
Medical Treatment ◽  
Bowel Disease ◽  
Early Onset ◽  
Biological Therapy ◽  
Cumulative Risk ◽  
Immunomodulatory Therapy ◽  
Inflammatory Bowel

Abstract Background To investigate the incidence of very early onset inflammatory bowel disease (VEO-IBD) in a cohort representing two regions in Denmark during the period 2015–2019 and to assess the medical and surgical treatment. Methods All patients diagnosed with VEO-IBD within The Capital Region and The Zealand Region from January 1, 2015 to July 1, 2020 were included. Demographic and clinical data and medical and surgical treatment were extracted from the files. Results Forty patients with VEO-IBD were identified. The incidence rate was 2.0/100,000 (CI 95% 0.8–5.9) during the 2015–2019. Totally 35 patients (87.5%) received immunomodulatory therapy during follow-up. The cumulative risk of receiving immunomodulatory therapy after 1 year, 3 years and 5 years was 58% (95% CI 39–71), 88% (95% CI 70–95) and 91% (95% CI 73–97) respectively. Totally 23 patients (57.5%) received biological therapy. The cumulative risk of receiving biological therapy after 1 year, 3 years and 5 years was 37% (95% CI 19–50), 46% (95% CI 27–60) and 57% (95% CI 36–71) respectively. Six patients (15%) received vedolizumab. Four patients (10%) with VEO-IBD underwent a colectomy during the follow-up period of which two patients received vedolizumab. Conclusion The incidence of VEO-IBD was 2.0/100,000. Medical treatment with immunomodulators and biological therapy was used extensively, possibly reducing surgery. However, medical treatment remains a complicated balancing of the effect (anti-inflammatory), side effect (cancer risk) and surgery in VEO-IBD.

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