The dynamics of solid-solid phase transitions 2. Incoherent interfaces

1994 ◽  
Vol 127 (1) ◽  
pp. 41-99 ◽  
Author(s):  
Paolo Cermelli ◽  
Morton E. Gurtin
Biomolecules ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1014
Author(s):  
Macy L. Sprunger ◽  
Meredith E. Jackrel

Aberrant protein folding underpins many neurodegenerative diseases as well as certain myopathies and cancers. Protein misfolding can be driven by the presence of distinctive prion and prion-like regions within certain proteins. These prion and prion-like regions have also been found to drive liquid-liquid phase separation. Liquid-liquid phase separation is thought to be an important physiological process, but one that is prone to malfunction. Thus, aberrant liquid-to-solid phase transitions may drive protein aggregation and fibrillization, which could give rise to pathological inclusions. Here, we review prions and prion-like proteins, their roles in phase separation and disease, as well as potential therapeutic approaches to counter aberrant phase transitions.


2018 ◽  
Author(s):  
P. Bowlan ◽  
L. Smilowitz ◽  
B. F. Henson ◽  
N. Suvorova ◽  
D. Oschwald

1988 ◽  
Vol 269O (1) ◽  
Author(s):  
B. Baranowski ◽  
M. Friesel ◽  
A. Lundén

2008 ◽  
Vol 26 (1) ◽  
pp. 216-219 ◽  
Author(s):  
Ke-Zhong WU ◽  
Jian-Ling LI ◽  
Jian-Jun ZHANG ◽  
Xiao-Di LIU

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