Felodipine in severe chronic congestive heart failure: Acute effects on central hemodynamics and regional blood flow distribution

1989 ◽  
Vol 3 (6) ◽  
pp. 903-911 ◽  
Author(s):  
Giorgio Binetti ◽  
Ida Rubino ◽  
Elisabetta Varani ◽  
Roberto Spadoni ◽  
Rossella Maria Ferretti ◽  
...  
1990 ◽  
Vol 15 (2) ◽  
pp. A238
Author(s):  
Kazushi Itoh ◽  
Hiroshi Yamabe ◽  
Yoshinori Yasaka ◽  
Hiroyuki Namura ◽  
Yasunori Hashimoto ◽  
...  

2012 ◽  
Vol 30 ◽  
pp. e234
Author(s):  
Daryl O. Schwenke ◽  
Matthew Beard ◽  
Takashi Sonobe ◽  
James T. Pearson ◽  
Hirotsugu Tsuchimochi ◽  
...  

Circulation ◽  
1984 ◽  
Vol 69 (1) ◽  
pp. 57-64 ◽  
Author(s):  
M E Leithe ◽  
R D Margorien ◽  
J B Hermiller ◽  
D V Unverferth ◽  
C V Leier

1995 ◽  
Vol 25 (1) ◽  
pp. 105-112 ◽  
Author(s):  
Stan A. J. van den Broek ◽  
Pieter A. de Graeff ◽  
Andries J. Smit ◽  
Armand R. J. Girbes ◽  
Louis Journée ◽  
...  

1994 ◽  
Vol 267 (3) ◽  
pp. H912-H917
Author(s):  
N. Imai ◽  
M. Kashiki ◽  
P. D. Woolf ◽  
C. S. Liang

We have shown previously that right heart failure (RHF) in dogs is associated with activated endogenous opiate systems, and that administration of the opioid receptor antagonist, naloxone, increases arterial pressure, cardiac contractile function and organ blood flows. To study whether the cardiovascular effects of naloxone are mediated via the mu- or delta-opioid receptors, we administered ICI-154,129, a delta-receptor antagonist, and naloxonazine, a mu-receptor antagonist, to 10 conscious dogs with RHF on 2 separate days. Like naloxone, ICI-154,129 increased mean aortic pressure, cardiac output, peak positive first derivative of left ventricular pressure, and blood flows to the myocardium, kidneys, splanchnic beds, and skeletal muscle. These changes were associated with increases in plasma epinephrine and norepinephrine. In contrast, naloxonazine had no effects on systemic hemodynamics, regional blood flow distribution, and plasma catecholamines in RHF. These findings suggest that the increased endogenous opioids during heart failure act on the delta-opioid receptors to decrease myocardial mechanical performance and alter regional blood flow distribution. Opioid receptor-blocking agents may exert beneficial cardiovascular effects in heart failure.


1995 ◽  
Vol 221 (5) ◽  
pp. 531-542 ◽  
Author(s):  
John J. Ferrara ◽  
D. Lynn Dyess ◽  
Guy L. Peeples ◽  
D. Paul Christenberry ◽  
W. Scott Roberts ◽  
...  

1983 ◽  
Vol 1 (6) ◽  
pp. 1391-1395 ◽  
Author(s):  
Steven R. Goldsmith ◽  
Gary S. Francis ◽  
T. Barry Levine ◽  
Jay N. Cohn

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