Effects of dimethindene maleate (Fenistil®) on histaminic, muscarinic and serotoninergic receptor systems

1992 ◽  
Vol 36 (S2) ◽  
pp. C428-C430 ◽  
Author(s):  
M. Sautel ◽  
R. Towart ◽  
M. Théraulaz-Lacroix ◽  
A. F. Weitsch
Keyword(s):  
Serotoninergic Receptor

Evidence that the anxiolytic-like effects of the beta3 receptor agonist Amibegron involve serotoninergic receptor activity

2013 ◽  
Vol 110 ◽  
pp. 27-32 ◽  
Author(s):  
Pelin Tanyeri ◽  
Mehmet Emin Buyukokuroglu ◽  
Oguz Mutlu ◽  
Guner Ulak ◽  
Furuzan Yildiz Akar ◽  
...  
Keyword(s):  
Receptor Agonist ◽  
Receptor Activity ◽  
Serotoninergic Receptor

Decrease of food intake by quipazine in the rat: relation to serotoninergic receptor stimulation

1977 ◽  
Vol 29 (1) ◽  
pp. 53-54 ◽  
Author(s):  
R. Samanin ◽  
C. Bendotti ◽  
F. Miranda ◽  
S. Garattini
Keyword(s):  
Food Intake ◽  
Receptor Stimulation ◽  
Serotoninergic Receptor

Expression of the 5-HT2A Serotoninergic Receptor in Human Placenta and Choriocarcinoma Cells: Mitogenic Implications of Serotonin

Placenta ◽  
2005 ◽  
Vol 26 (6) ◽  
pp. 484-490 ◽  
Author(s):  
B. Sonier ◽  
C. Lavigne ◽  
M. Arseneault ◽  
R. Ouellette ◽  
C. Vaillancourt
Keyword(s):  
Human Placenta ◽  
Choriocarcinoma Cells ◽  
Serotoninergic Receptor

scholarly journals Two New βN-Alkanoyl-5-Hydroxytryptamides with Relevant Antinociceptive Activity

Biomedicines ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 455
Author(s):  
Jorge Luis Amorim ◽  
Fernanda Alves Lima ◽  
Ana Laura Macedo Brand ◽  
Silvio Cunha ◽  
Claudia Moraes Rezende ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Antinociceptive Activity ◽  
Heated Plate ◽  
Plate Model ◽  
Cannabinoid Cb1 Receptor ◽  
Hot Plate ◽  
Antinociceptive Effects ◽  
New Compounds ◽  
Induced Reaction ◽  
Serotoninergic Receptor

In this work, we describe a new route for the synthesis and the antinociceptive effects of two new βN-alkanoyl-5-hydroxytryptamides (named C20:0-5HT and C22:0-5HT). The antinociceptive activities were evaluated using well-known models of thermal-induced (reaction to a heated plate, the hot plate model) or chemical-induced (licking response to paw injection of formalin, capsaicin, or glutamate) nociception. The mechanism of action for C20:0-5HT and C22:0-5HT was evaluated using naloxone (opioid receptor antagonist, 1 mg/kg), atropine (muscarinic receptor antagonist, 1 mg/kg), AM251 (cannabinoid CB1 receptor antagonist, 1 mg/kg), or ondansetron (5-HT3 serotoninergic receptor antagonist, 0.5 mg/kg) 30 min prior to C20:0-5HT or C22:0-5HT. The substances both presented significant effects by reducing licking behavior induced by formalin, capsaicin, and glutamate and increasing the latency time in the hot plate model. Opioidergic, muscarinic, cannabinoid, and serotoninergic pathways seem to be involved in the antinociceptive activity since their antagonists reversed the observed effect. Opioid receptors are partially involved due to tolerant mice demonstrating less antinociception when treated with both compounds. Our data showed a quicker and simpler route for the synthesis of the new βN-alkanoyl-5-hydroxytryptamides. Both compounds demonstrated significant antinociceptive effects. These new compounds could be used as a scaffold for the synthesis of analogues with promising antinociceptive effects.

5-HT2A serotoninergic receptor in the locus coeruleus participates in the first phase of lipopolysaccharide-induced fever

2007 ◽  
Vol 85 (5) ◽  
pp. 497-501 ◽  
Author(s):  
Alexandre O. Fernandes da Silva ◽  
Luciane H. Gargaglioni ◽  
Luiz G.S. Branco
Keyword(s):  
Body Temperature ◽  
Locus Coeruleus ◽  
Bacterial Lipopolysaccharide ◽  
Febrile Response ◽  
Way 100635 ◽  
Serotoninergic Receptors ◽  
Serotoninergic Receptor

This study was aimed at testing the hypothesis that serotoninergic receptors in the locus coeruleus (LC) play a role in bacterial lipopolysaccharide-induced fever. To this end, 5-HT1A (WAY-100635; 3 μg/100 nL) and 5-HT2A (ketanserin; 2 μg/100 nL) antagonists were microinjected into the LC and body temperature was monitored by biotelemetry. Intra-LC microinjections of ketanserin or WAY-100635 caused no change in body temperature of euthermic animals. 5-HT2A antagonism abolished the first phase of the lipopolysaccharide-induced fever. Taken together, these results indicate that serotonin acting on 5-HT2A receptors in the LC mediates the first phase of the febrile response, whereas 5-HT1A receptors are not involved in the lipopolysaccharide-induced fever.

The serotoninergic receptor subtype 5-HTR1B contributes to the pathogenesis of allergic airway inflammation

Pneumologie ◽  
2012 ◽  
Vol 66 (11) ◽  
Author(s):  
T Müller ◽  
A Hüttel ◽  
M Idzko
Keyword(s):  
Airway Inflammation ◽  
Allergic Airway Inflammation ◽  
Receptor Subtype ◽  
Serotoninergic Receptor

Effect of serotoninergic receptor blockers upon diffuse noxious inhibitory controls (dnic)

Pain ◽  
1981 ◽  
Vol 11 ◽  
pp. S241
Author(s):  
D. Chitour ◽  
A. H. Dickenson ◽  
D. Le Bars
Keyword(s):  
Diffuse Noxious Inhibitory Controls ◽  
Receptor Blockers ◽  
Serotoninergic Receptor

Serotoninergic receptor activation by dextrofenfluramine enhances the blunted pituitary-adrenal responsiveness to corticotropin-releasing hormone in obese subjects

Metabolism ◽  
1992 ◽  
Vol 41 (1) ◽  
pp. 17-21 ◽  
Author(s):  
G.P. Bernini ◽  
G.F. Argenio ◽  
C. Del Corso ◽  
M.S. Vivaldi ◽  
R. Birindelli ◽  
...  
Keyword(s):  
Receptor Activation ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Obese Subjects ◽  
Serotoninergic Receptor

The 5-HT2A serotoninergic receptor is expressed in the MCF-7 human breast cancer cell line and reveals a mitogenic effect of serotonin

2006 ◽  
Vol 343 (4) ◽  
pp. 1053-1059 ◽  
Author(s):  
Brigitte Sonier ◽  
Madeleine Arseneault ◽  
Carole Lavigne ◽  
Rodney J. Ouellette ◽  
Cathy Vaillancourt
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Breast Cancer Cell Line ◽  
Human Breast Cancer ◽  
Cancer Cell Line ◽  
Human Breast Cancer Cell ◽  
Mitogenic Effect ◽  
Human Breast ◽  
Serotoninergic Receptor ◽  
Mcf 7

S.15.03 Serotoninergic receptor subtypes in cognition

2003 ◽  
Vol 13 ◽  
pp. S135-S136
Author(s):  
M.C. Buhot ◽  
M. Wolff ◽  
L. Segu
Keyword(s):  
Receptor Subtypes ◽  
Serotoninergic Receptor
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