Mechanism of action of H2-antagonists on histamine-or dimaprit-stimulated H2-receptors of spontaneously beating guinea-pig atrium

1990 ◽  
Vol 31 (1-2) ◽  
pp. 23-35 ◽  
Author(s):  
M. J. Krielaart ◽  
D. M. J. Veenstra ◽  
K. J. H. Buuren
Keyword(s):  
Guinea Pig ◽  
Mechanism Of Action ◽  
H2 Antagonists ◽  
H2 Receptors ◽  
Guinea Pig Atrium

scholarly journals Mechanism of Action of Guinea Pig Liver Transglutaminase

1970 ◽  
Vol 245 (23) ◽  
pp. 6424-6435 ◽  
Author(s):  
S.I. Chung ◽  
R.I. Shrager ◽  
J.E. Folk
Keyword(s):  
Guinea Pig ◽  
Mechanism Of Action ◽  
Pig Liver ◽  
Guinea Pig Liver

scholarly journals Mechanism of Action of Guinea Pig Liver Transglutaminase

1967 ◽  
Vol 242 (11) ◽  
pp. 2615-2621 ◽  
Author(s):  
J.E. Folk ◽  
P.W. Cole ◽  
J.P. Mullooly
Keyword(s):  
Guinea Pig ◽  
Mechanism Of Action ◽  
Pig Liver ◽  
Guinea Pig Liver

Occurrence of H2-receptors for histamine in the guinea-pig intestine

1975 ◽  
Vol 24 (11-12) ◽  
pp. 1215-1219 ◽  
Author(s):  
Ivone Bareicha ◽  
M.Rocha e Silva
Keyword(s):  
Guinea Pig ◽  
H2 Receptors

Ouabain uptake by endocytosis in isolated guinea pig atria

1988 ◽  
Vol 255 (4) ◽  
pp. C479-C485 ◽  
Author(s):  
H. Nunez-Duran ◽  
L. Riboni ◽  
E. Ubaldo ◽  
E. Kabela ◽  
L. Barcenas-Ruiz
Keyword(s):  
Electron Microscope ◽  
Guinea Pig ◽  
Mammalian Cells ◽  
Isometric Tension ◽  
Cardiac Cells ◽  
Inotropic Effect ◽  
Experimental Protocols ◽  
Guinea Pig Atrium ◽  
Endocytic Vesicles ◽  
Guinea Pig Atria

Mammalian cells specifically internalize some molecular species through receptor-mediated endocytosis (RME). We have used four different experimental protocols to investigate whether ouabain enters cardiac cells of guinea pig atrium through this pathway. First, by electron microscope morphometry we found that ouabain increased endocytic vesicles in atrial cells. Second, by scintillation counting we found that [3H]ouabain uptake by the tissue is decreased by three treatments that decrease RME, i.e., NH4Cl, trifluoperazine, and 16 mM [K+]0. Third, by radioautography at the electron microscope level, we checked that in preceding experiments [3H]ouabain was washed out of plasma membrane after 60-min rinse and interiorized into the cardiac cells. Fourth, isometric tension recordings showed that the positive inotropic effect of ouabain was diminished in the presence of inhibitors, whereas that of a hydrophobic analogue, ouabagenin, was not affected. These results suggest that ouabain enters cardiac cells through RME and also that an intracellular site may, at least in part, be responsible for its inotropic effect.

scholarly journals Calcium Exchange and Contraction Strength of Guinea Pig Atrium in Normal and Hypertonic Media

1969 ◽  
Vol 54 (4) ◽  
pp. 494-511 ◽  
Author(s):  
Gerald R. Little ◽  
William W. Sleator
Keyword(s):  
Steady State ◽  
Ion Exchange ◽  
Guinea Pig ◽  
Extracellular Space ◽  
Entry Rate ◽  
Steady State Condition ◽  
Peak Tension ◽  
Guinea Pig Atrium ◽  
Calcium Exchange ◽  
The Difference

A Krebs-Henseleit (KH) medium made hypertonic by adding nonpermeant molecules substantially increased the isometric peak tension at steady-state contractions below 3 per sec in guinea pig atrium at 27°C. Action potential durations were decreased. KH plus 100 mM raffinose or sucrose resulted in similar and nearly maximal changes which were essentially reversible upon return to normal KH. When one active contracting atrium was used to passively stretch a second atrium, the difference in Ca ion exchange (1 min exchange with the extracellular space) between active and stretched atria significantly increased at 1 per sec and at 2 per sec in going from normal to 100 mM hypertonic KH. The calculated mean Ca ion cellular exchange per beat per 100 g of cells (a) doubled in changing from normal to 100 mM hypertonic KH, and (b) decreased slightly in changing from contractions of 1 per sec to 2 per sec in normal KH. These data are consistent with the hypothesis (a) that Ca ion entry per beat from the extracellular space is proportional to membrane depolarized time with a constant medium and a steady-state condition, and the hypothesis (b) that 100 mM hypertonicity doubles the Ca ion entry rate during depolarization. These data enable rejection of the hypothesis that the peak tension is proportional to the Ca ion entry per beat from the extracellular space under steady-state conditions, and suggest that any additional Ca ion involved in the larger contractions at higher frequencies comes from an increase in Ca ion available from intracellular stores.

Positive inotropic effect of prostacyclin on isolated guinea-pig atria. Mechanism of action

1984 ◽  
Vol 27 ◽  
pp. 32
Author(s):  
G. Fassina ◽  
L. Perissinotto
Keyword(s):  
Guinea Pig ◽  
Mechanism Of Action ◽  
Positive Inotropic Effect ◽  
Inotropic Effect ◽  
Guinea Pig Atria

scholarly journals Use-dependent block of Ca2+ current by moricizine in guinea-pig ventricular myocytes: a possible ionic mechanism of action potential shortening

1993 ◽  
Vol 108 (3) ◽  
pp. 812-818 ◽  
Author(s):  
Tei-ichi Yamane ◽  
Akihiko Sunami ◽  
Tohru Sawanobori ◽  
Masayasu Hiraoka
Keyword(s):  
Guinea Pig ◽  
Action Potential ◽  
Mechanism Of Action ◽  
Ventricular Myocytes ◽  
Ionic Mechanism ◽  
Action Potential Shortening

Compound-X-induced TdP in the anesthetized guinea-pig: Unraveling the mechanism of action

2010 ◽  
Vol 62 (2) ◽  
pp. e23
Author(s):  
Brigitte G.P. Loenders ◽  
Jan Verrelst ◽  
Hua Rong Lu ◽  
Eddy Vlaminckx ◽  
Jutta Rohrbacher ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Mechanism Of Action
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