Ultrastructure of electrophysiologically identified human sinoatrial nodes

1988 ◽  
Vol 83 (4) ◽  
pp. 401-409 ◽  
Author(s):  
J. E. Lowe ◽  
T. Hartwich ◽  
M. Takla ◽  
J. Schaper
Keyword(s):  
Sinoatrial Nodes

scholarly journals Functional Roles of Ca v 1.3 (α 1D ) Calcium Channel in Sinoatrial Nodes

2002 ◽  
Vol 90 (9) ◽  
pp. 981-987 ◽  
Author(s):  
Zhao Zhang ◽  
Yanfang Xu ◽  
Haitao Song ◽  
Jennifer Rodriguez ◽  
Dipika Tuteja ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Functional Roles ◽  
Sinoatrial Nodes

scholarly journals The Chronotropic Function of Propofol and the Underlying Mechanism in Rabbits

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Wenjie Cheng ◽  
Xiaohua Sun ◽  
Yanfang Liu ◽  
Shiqi Han ◽  
Wanlu Ren
Keyword(s):  
Heart Rate ◽  
Action Potentials ◽  
Sinus Node ◽  
Underlying Mechanism ◽  
Dependent Manner ◽  
Pacemaker Cells ◽  
Concentration Dependent Manner ◽  
Sinoatrial Nodes ◽  
Chronotropic Action ◽  
Dose Dependent

The report of bradycardia caused by propofol is increasing. In the experiment, we investigated the chronotropic function of propofol and the underlying mechanism. Rabbits of both sexes were randomly divided into 4 groups: propofol 5 mg/kg group, 10 mg/kg group, 15 mg/kg group, and sham group. Heart rate and frequency of vagal efferent discharge were recorded before the injection and 0, 0.5, 1, 2, and 10 min after the injection through intravenous mode. Then, their hearts were removed, and sinoatrial nodes were dissected. The action potentials of the sinus node pacemaker cells were recorded by the intracellular glass microelectrode technique, and the sinoatrial (SA) node was exposed to propofol 1, 3, 5, and 10 µM respectively. The action potentials were recorded after the sinoatrial nodes were exposed to each concentration of propofol for 15 min. Our results show that the heart rate significantly decreased, and the vagal efferent discharge was significantly increased at 0, 0.5, 1, and 2 min after the injection, respectively. Besides, as the dose increases, the magnitude of change shows a dose-dependent manner. Propofol exerts a negative chronotropic action on sinoatrial node pacemaker cells. The drug significantly decreased APA, VDD, RPF, and prolonged APD90 in a concentration-dependent manner. These effects may be the main mechanism of propofol-induced bradycardia in clinical study.

Biophysical Model of Sinoatrial Nodes Bioelectrical Activity to Simulate Heart Rate Variability in Normal and Diabetic Patients

2009 ◽  
Vol 4 (2) ◽  
pp. 88-100 ◽  
Author(s):  
Dhanjoo Ghista ◽  
Roustem Miftahof ◽  
Rajendra Acharya ◽  
Kamlakar Desai
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Biophysical Model ◽  
Diabetic Patients ◽  
Bioelectrical Activity ◽  
Sinoatrial Nodes

The pacemaker cell of the sinoatrial node of the rabbit

1978 ◽  
Vol 235 (4) ◽  
pp. H407-H412 ◽  
Author(s):  
J. J. Taylor ◽  
L. S. D'Agrosa ◽  
E. M. Burns
Keyword(s):  
Action Potential ◽  
Sinoatrial Node ◽  
Pacemaker Cell ◽  
Cell Of Origin ◽  
Pacemaker Potential ◽  
Sinoatrial Nodes ◽  
P Cells ◽  
Pacemaker Action

Rabbit sinoatrial nodes were isolated and studied in an attempt to determine the cell of origin of the true pacemaker potential. Cells of the sinoatrial node of the rabbit giving rise to the characteristic true pacemaker potential were iontophoretically tagged with lanthanum. The lanthanum appeared within the cytoplasm of cells, which morpholigically are (P) cells. The lanthanum appeared as small, amorphous, electron-dense globules. It is concluded from this study that the P or pale cell is the source of the true pacemaker action potential of the sinoatrial node.

Two cases of congenital asplenia with isomerism of the cardiac atria and the sinoatrial nodes

1964 ◽  
Vol 13 (3) ◽  
pp. 407-414 ◽  
Author(s):  
Lodewyk H.S. Van Mierop ◽  
Paul R. Patterson ◽  
Ralph W. Reynolds
Keyword(s):  
Sinoatrial Nodes

scholarly journals Anatomopathological changes in canine distemper seropositive dogs and virus detection in sinoatrial nodes

2020 ◽  
Vol 36 (2) ◽  
Author(s):  
José Eugenio Diniz Bastos ◽  
Neide Maria Silva ◽  
Marisol Patrícia Pallete Briceño ◽  
Tais Meziara Wilson ◽  
Alessandra Aparecida Medeiros-Ronchi
Keyword(s):  
Sinoatrial Node ◽  
Virus Detection ◽  
Viral Disease ◽  
Canine Distemper ◽  
Rt Pcr ◽  
Bladder Epithelium ◽  
Concentric Hypertrophy ◽  
Lymphocytic Myocarditis ◽  
Sinoatrial Nodes ◽  
Viral Inclusions

Canine distemper is a viral disease that affects several systems on dogs, among them, the cardiovascular system. The aim of this study was to identify canine distemper virus (CDV) in the sinoatrial node (SAN) of dogs serologically positive for distemper by Polymerase Chain Reaction preceded by reverse transcription (RT-PCR), and to analyze gross and microscopic changes of distemper in the heart and other tissues. SAN and tissue fragments were collected from 17 serologically positive dead animals, necropsied from October 2015 to December 2016. In the heart, right heart dilatation was observed in 13 dogs (76.47%) and left concentric hypertrophy in two dogs (11.76%). Microscopically, lymphocytic myocarditis was observed in four (23.53%) dogs and 41.18% presented viral inclusion corpuscles of CDV in the bladder epithelium. Only one (5.88%) dog presented a 319 bp target fragment for distemper virus using primers CDV 1 and CDV 2 at the sinoatrial node. In conclusion, CDV can be located in the sinoatrial node of naturally infected dogs, as demonstrated in this study by the RT-PCR technique, reinforcing the hypothesis that CDV is capable of causing inflammatory lesions in the sinoatrial node of this species. Macroscopic and microscopic cardiac changes are frequently observed in dogs with distemper, mainly cardiac dilatation and myocarditis. Viral inclusions of CDV in bladder epithelial cells are an important microscopic finding for the diagnosis of distemper.

Levosimendan differentially modulates electrophysiological activities of sinoatrial nodes, pulmonary veins, and the left and right atria

2018 ◽  
Vol 29 (8) ◽  
pp. 1150-1158 ◽  
Author(s):  
Yung-Kuo Lin ◽  
Yao-Chang Chen ◽  
Yi-Ann Chen ◽  
Jen-Hung Huang ◽  
Shih-Ann Chen ◽  
...  
Keyword(s):  
Pulmonary Veins ◽  
Sinoatrial Nodes ◽  
Left And Right ◽  
Right Atria

scholarly journals Evidence of Superior and Inferior Sinoatrial Nodes in the Mammalian Heart

2020 ◽  
Vol 6 (14) ◽  
pp. 1827-1840
Author(s):  
Jaclyn A. Brennan ◽  
Qing Chen ◽  
Anna Gams ◽  
Jhansi Dyavanapalli ◽  
David Mendelowitz ◽  
...  
Keyword(s):  
Mammalian Heart ◽  
Sinoatrial Nodes
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