Three-Dimensional Biomechanical Finite Element Analysis of Lumbar Disc Herniation in Middle Aged and Elderly

Lumbar intervertebral disc protrusion disease refers to the degeneration of intervertebral disc, rupture of fibrous ring, nucleus pulpous protrusion and stimulation or compression of nerve root. The import command in Mimics medical 3D reconstruction software was used to erase the irrelevant image data and obtain vertebral body images. The original 3D model of each vertebral body was built by 3D computing function. A three-dimensional finite element model was established to analyze the effect of different surgical methods on the mechanical distribution of the spine after disentomb. The stress distribution of the spine, intervertebral disc, and left and right articular cartilage at L4/L5 stage and the position shift of the fourth lumbar vertebra were analyzed under 7 working conditions of vertical, forward flexion, extension, left and right flexion, and left and right rotation. The results showed that the established model was effective, and the smaller the area of posterior laminar decompression was, the lesser the impact on spinal stability was. The PELD treatment of lumbar disc herniation had little impact on spinal biomechanics and could achieve good long-term biomechanical stability. Combining the clinical experiment method and finite element simulation, using the advantages of finite element software to optimize the design function can provide guidance for the design and improvement of medical devices and has important significance for the study of clinical mechanical properties and biomechanics.

MicroRNA-517c Functions as a Tumor Suppressor in Hepatocellular Carcinoma via Downregulation of KPNA2 and Inhibition of PI3K/AKT Pathway

Objective. Hepatocellular carcinoma (HCC) is a kind of solid and highly aggressive malignant tumor with poor prognosis. MicroRNA (miRNA/miR) has been confirmed to be involved in HCC development. The current study focused on the functions and mechanisms of miR-517c in HCC. Methods. Expressions of miR-517c and Karyopherin α2 (KPNA2) mRNA in HCC cell lines and tissue samples were examined using quantitative real-time polymerase chain reaction (qRT-PCR). Western blot was conducted for detections of epithelial-to-mesenchymal transition (EMT) and PI3K/AKT markers. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and Transwell assays were utilized to investigate the influence of miR-517c on HCC cell proliferation, invasion, and migration. TargetScan and luciferase reporter assay were performed to search for the potential target gene of miR-517c. Results. We demonstrated that miR-517c expressions were decreased in HCC tissues and cells. Moreover, the clinical analysis showed that decreased miR-517c expressions in HCC tissues correlated with shorter overall survival and malignant clinicopathologic features of HCC patients. MTT assay showed that miR-517c upregulation prominently repressed HCC cell proliferation. In addition, miR-517c restoration could significantly suppress HCC cell invasion and migration as demonstrated by Transwell assays. We also found that miR-517c directly targeted KPNA2 and regulated the PI3K/AKT pathway and EMT, exerting prohibitory functions in HCC. Conclusion. Taken together, this study stated that miR-517c inhibited HCC progression via regulating the PI3K/AKT pathway and EMT and targeting KPNA2 in HCC, providing a novel insight into HCC treatment.

Application and Feasibility Study of Integrated Nursing Information Construction in Nephrology Nursing

With the continuous deepening of medical reforms and the continuous attempts and explorations of various management models, the traditional health care model is undergoing tremendous changes, and patients’ needs for medical institutions are becoming more and more comprehensive. Medical institutions are meeting the needs of providing medical services to patients at the same time. It is even more necessary to change our thinking and enhance the service concept. This article is based on case-based deep learning hospital nursing business process reengineering and the application and feasibility study of integrated nursing information construction in nephrology nursing. This article uses the literature analysis method, the social survey method, and other methods to discuss the construction of integrated nursing information. On the one hand, the content of this article uses the concept of process reengineering to analyze the current development status and existing problems of the hospital care industry and find countermeasures to solve problems. On the other hand, the main research content of this article is the construction of integrated nursing information and its analysis of the application and feasibility of nursing in the nephrology department. At the same time, under the background of the rapid development of the mobile Internet, we will carry out extended thinking on the continuous transformation of the construction of nursing information. According to the survey results, 87.5% of patients in the nephrology department are dissatisfied with the current hospital’s work efficiency, and 85.7% of the nursing staff in the nephrology department are generally satisfied with the information management of the current department. After the implementation of the hospital information integration system, patient satisfaction is as high as 98.2%, and the satisfaction of medical staff reached 94.2%. The construction of integrated nursing information has played a great role in the application of nephrology nursing.

Analysis on the Influence of Students’ Health Quality Based on Intelligent Optimization of Sports Facilities and Equipment

Physical health promotion has always been a way for schools to pay close attention to and devote resources to their students’ development, physical fitness, and social adaptability. To promote the improvement of students’ overall physical quality, we must begin with the foundation and school physical education. This study proposes an improved K-means algorithm based on an analysis of the influencing factors of intelligent optimization of sports facilities and equipment on students’ health quality. Clustering analysis is carried out based on two groups of data classified as boys and girls, using the improved K-means algorithm. The findings reveal that the average change trend of physical fitness test items in each male cluster is generally similar, with a moderate change. The change in the average score of physical fitness test items for each cluster of girls in the group showed two distinct valleys, and the trend was complicated. This necessitates schools to invest funds to construct venues and purchase equipment in order to increase the number of sporting events.

Effect of Huaiqihuang Granules Combined with Comprehensive Nursing on Children with Primary Nephrotic Syndrome

Background. To observe the effect of Huaiqihuang granules combined with comprehensive nursing intervention on children with primary nephrotic syndrome (PNS) and its effect on renal function index. Methods. A total of 104 patients were included, and the patients were randomly divided into two groups, with 52 cases in each group. The control group was treated with glucocorticoid, and the study group was treated with Huaiqihuang granules. The clinical efficacy of the two groups was observed. The levels of TG, TC, EGFR, 24 h UTP, BUN, Scr, IgA, IgG, IgM, IFN-γ and TNF-α were compared between two groups before and after treatment. The incidence of adverse reactions and recurrence rate after treatment were compared between the two groups. Results. The effective rate of the study group (94.23%) was significantly higher than that of the control group (78.85%). Before treatment, there was no significant difference in TG and TC levels between the two groups. After treatment, the levels of TG and TC in both groups were decreased, and the decrease was more obvious in the study group. Compared with before treatment, the levels of 24 h UTP, BUN, Scr, IFN-γ, and TNF-α in both groups were significantly decreased after treatment, while EGFR, IgA, IgG, and IgM levels were significantly increased. Compared with the control group, the changes of each index in the study group were more obvious after treatment. After treatment, the incidence of adverse reactions and recurrence rate in the study group were significantly lower than those in the control group. Conclusions. Huaiqihuang granules combined with comprehensive nursing treatment in children with PNS can reduce the occurrence of recent recurrence and adverse reactions and improve the cellular immune function and renal function.

A Novel Clustering-Based Algorithm for Continuous and Noninvasive Cuff-Less Blood Pressure Estimation

Extensive research has been performed on continuous and noninvasive cuff-less blood pressure (BP) measurement using artificial intelligence algorithms. This approach involves extracting certain features from physiological signals, such as ECG, PPG, ICG, and BCG, as independent variables and extracting features from arterial blood pressure (ABP) signals as dependent variables and then using machine-learning algorithms to develop a blood pressure estimation model based on these data. The greatest challenge of this field is the insufficient accuracy of estimation models. This paper proposes a novel blood pressure estimation method with a clustering step for accuracy improvement. The proposed method involves extracting pulse transit time (PTT), PPG intensity ratio (PIR), and heart rate (HR) features from electrocardiogram (ECG) and photoplethysmogram (PPG) signals as the inputs of clustering and regression, extracting systolic blood pressure (SBP) and diastolic blood pressure (DBP) features from ABP signals as dependent variables, and finally developing regression models by applying gradient boosting regression (GBR), random forest regression (RFR), and multilayer perceptron regression (MLP) on each cluster. The method was implemented using the MIMIC-II data set with the silhouette criterion used to determine the optimal number of clusters. The results showed that because of the inconsistency, high dispersion, and multitrend behavior of the extracted features vectors, the accuracy can be significantly improved by running a clustering algorithm and then developing a regression model on each cluster and finally weighted averaging of the results based on the error of each cluster. When implemented with 5 clusters and GBR, this approach yielded an MAE of 2.56 for SBP estimates and 2.23 for DBP estimates, which were significantly better than the best results without clustering (DBP: 6.27, SBP: 6.36).

Deep Learning Application for Effective Classification of Different Types of Psoriasis

Psoriasis is a chronic inflammatory skin disorder mediated by the immune response that affects a large number of people. According to latest worldwide statistics, 125 million individuals are suffering from psoriasis. Deep learning techniques have demonstrated success in the prediction of skin diseases and can also lead to the classification of different types of psoriasis. Hence, we propose a deep learning-based application for effective classification of five types of psoriasis namely, plaque, guttate, inverse, pustular, and erythrodermic as well as the prediction of normal skin. We used 172 images of normal skin from the BFL NTU dataset and 301 images of psoriasis from the Dermnet dataset. The input sample images underwent image preprocessing including data augmentation, enhancement, and segmentation which was followed by color, texture, and shape feature extraction. Two deep learning algorithms of convolutional neural network (CNN) and long short-term memory (LSTM) were applied with the classification models being trained with 80% of the images. The reported accuracies of CNN and LSTM are 84.2% and 72.3%, respectively. A paired sample T-test exhibited significant differences between the accuracies generated by the two deep learning algorithms with a p < 0.001 . The accuracies reported from this study demonstrate potential of this deep learning application to be applied to other areas of dermatology for better prediction.

Factors Affecting Adenoma Risk Level in Patients with Intestinal Polyp and Association Analysis

Objective. To explore the factors affecting the adenoma risk level in patients with intestinal polyp and association. Methods. The clinical data of 3,911 patients with intestinal polyp treated in our hospital from January 2018 to January 2021 were retrospectively analyzed, all patients accepted the histopathological examination, their risk of suffering from adenoma was evaluated according to the results of pathological diagnosis, and relevant hazard factors affecting adenoma risk level in them were analyzed by multifactor logistic regression analysis. Results. The results of multifactor logistic analysis showed that male gender, age ≥60 years, number of polyps >3, diameter ≥2 cm, onset at colon, and physiologically tubulovillous adenoma were the hazard factors causing high-grade adenoma risk in patients with intestinal polyp. Conclusion. There are many risk factors causing high-grade adenoma in patients with intestinal polyp, and therefore, the screening for high-risk population shall be enhanced to reduce the potential of carcinomatous change in such patients.

The Significance of Apolipoprotein-A in the Long-Term Death of Patients with STEMI

Objective. To analyze apolipoprotein-A for its predictive value for long-term death in individuals suffering from acute ST-segment elevation myocardial infarction following percutaneous coronary intervention. Methods. We selected patients suffering from acute ST-segment elevation myocardial infarction who underwent emergency PCI at the Affiliated Hospital of Putian University from January 2017 to August 2019. The patients were divided into a high-Apo-A group and low-Apo-A group, and we observed all-cause deaths of patients in the 2 groups within 2 years. Results. The ROC curve analysis indicated the best critical value for predicting 2-year mortality as 0.8150 (area under the curve was 0.626, sensitivity 75.1%, and specificity 51.9%). There was no statistical difference among the two groups in gender, age, lesion vessel, and comorbidities. The two groups had statistically significant differences in apolipoprotein-B/A, high-density lipoprotein, apolipoprotein-A, and hypersensitivity C-reactive protein. Correlation analysis showed a significant negative correlation between apolipoprotein-A and hypersensitive C-reactive protein. The results of the 24-month analysis indicated the incidence of all-cause mortality as higher in the low-Apo-A group, and Kaplan–Meier survival analysis showed the same trend. Conclusion. Apolipoprotein-A can predict the potential for long-term mortality among individuals having acute ST-segment elevation myocardial infarction.

Effects of Equine-Assistant Activity on Gross Motor Coordination in Children Aged 8 to 10 Years

Generally, adequate motor coordination (MC) ability is one among the critical factors for the overall development of children. In this paper, we have thoroughly analyzed the effects of equine-assistant activity (EAA) training on MC in children. For this purpose, MC test, specifically for children, was used to the Körperkoordinationstest für Kinder (KTK), and a total of 100 children, particularly those in 8 to 10 age, were equally separated into equine-assistant activity group (EAAG) and control group (CG), respectively. The EAAG group has attended a 14-week EAA training program, while the CG joined in physical education activity once per week. The experimental results have indicated that four indices of KTK test (i.e., backward walk [WB], height jump [HH], jumping sideways [JS] and moving sideways [MS], and motor quotient [MQ] score) showed significant differences ( ∗ P < 0.05 ) after a 14-week EAA training. Furthermore, the indices of physical fitness test, standing long jump (SLJ), and sit and reach (SAR) showed significant differences ( ∗ P < 0.05 ), but the handgrip (HG) increased slightly without significant difference ( P > 0.05 ) after a 14-week EAA training. In conclusion, there were improvements in MC, lower limb strength, and flexibility by EAAG for those who participated in a 14-week EAA training, and this study has demonstrated the effectiveness of the KTK assessment of MC in children 8 to 10 years.