Success of intrauterine insemination using cryopreserved donor sperm is related to the age of the woman and the number of preovulatory follicles

1996 ◽  
Vol 13 (4) ◽  
pp. 310-314 ◽  
Author(s):  
Rudiger U. Pittrof ◽  
Adel Shaker ◽  
Nicola Dean ◽  
Jinan S. Bekir ◽  
Stuart Campbell ◽  
...  
Keyword(s):  
Intrauterine Insemination ◽  
Donor Sperm ◽  
Preovulatory Follicles

Male Infertility: Surgical Treatment (Varicocele, Microsurgical Reconstruction, TUR Ejaculatory Ducts)

2019 ◽  
Author(s):  
Vanessa L. Dudley ◽  
Marc Goldstein
Keyword(s):  
Intrauterine Insemination ◽  
Ejaculatory Duct ◽  
Obstructive Azoospermia ◽  
Male Factor Infertility ◽  
Nonobstructive Azoospermia ◽  
Male Factor ◽  
Sperm Retrieval ◽  
Donor Sperm ◽  
Vitro Fertilization

Male factor infertility contributes to at least half of all cases of infertility in couples. The most common causes of male factor infertility are impaired sperm production due to varicoceles, obstruction of the ductal system, and genetic defects causing nonobstructive azoospermia. A majority of these underlying conditions are treatable. Even when in vitro fertilization with intracytoplasmic sperm injection (IVF-ICSI) is necessary, treatment of men has been shown to improve the outcomes of IVF-ICSI and potentially increase the chances of finding sperm with microdissection sperm extraction in some cases of nonobstructive azoospermia. Important advances in the field include abundant evidence now supporting microsurgical repair of varicocele in varicocele-associated nonobstructive azoospermia prior to IVF-ICSI or attempted surgical sperm retrieval. Advances in techniques for reconstruction of obstruction is dependent on the surgeon’s skill in creating a tension-free and leak-proof mucosa-to-mucosa accurate approximation with a good blood supply and healthy mucosa and muscularis and can result in higher patency rates. Treating the men often allows upgrading men from being solely candidates for donor sperm or adoption to candidates for ICF-ICSI with surgically retrieved testicular sperm to allowing IVF-ICSI with ejaculated sperm and from IVF-ICSI with ejaculated sperm to allowing the simpler intrauterine insemination and, finally, the possibility of a naturally conceived pregnancy. This review contains 27 figures, 1 table, and 69 references. Key Words: microsurgery, obstructive azoospermia, transurethral resection of the ejaculatory duct, varicocele, vasectomy reversal, vasoepididymostomy, vasography, vasovasostomy

scholarly journals IS THE MID-LUTEAL PROGESTERONE CHECK AN EXAMPLE OF MEDICALIZATION IN THE TREATMENT OF SAME-SEX FEMALE COUPLES UNDERGOING DONOR SPERM INTRAUTERINE INSEMINATION?

2020 ◽  
Vol 114 (3) ◽  
pp. e90
Author(s):  
Jenna Friedenthal ◽  
Joseph A. Lee ◽  
Noah Copperman ◽  
Daniel E. Stein ◽  
Tanmoy Mukherjee ◽  
...  
Keyword(s):  
Intrauterine Insemination ◽  
Same Sex ◽  
Donor Sperm

scholarly journals What is the ideal number of vials of donor sperm to purchase for patients undergoing donor sperm intrauterine insemination (DIUI)?

2019 ◽  
Vol 112 (3) ◽  
pp. e96-e97
Author(s):  
Sydney Chang ◽  
Dmitry Gounko ◽  
Joseph A. Lee ◽  
Melissa Bell ◽  
Margaret Daneyko ◽  
...  
Keyword(s):  
Intrauterine Insemination ◽  
Donor Sperm ◽  
Ideal Number ◽  
The Ideal

scholarly journals INTRACERVICAL INSEMINATION AND INTRAUTERINE INSEMINATION FOR DONOR SPERM TREATMENT IN THE NATURAL CYCLE: A RANDOMIZED CONTROLLED TRIAL

2020 ◽  
Vol 114 (3) ◽  
pp. e101-e102
Author(s):  
Petronella A.L. Kop ◽  
M. van Wely ◽  
Alexandre Soufan ◽  
Annemieke Aagje de Melker ◽  
Ben W. Mol ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Intrauterine Insemination ◽  
Controlled Trial ◽  
Natural Cycle ◽  
Donor Sperm ◽  
Randomized Controlled

scholarly journals Single-donor and double-donor sperm intrauterine insemination cycles: does double intrauterine insemination increase clinical pregnancy rates?

2014 ◽  
Vol 102 (3) ◽  
pp. 739-743 ◽  
Author(s):  
Shvetha M. Zarek ◽  
Micah J. Hill ◽  
Kevin S. Richter ◽  
Mae Wu ◽  
Alan H. DeCherney ◽  
...  
Keyword(s):  
Intrauterine Insemination ◽  
Pregnancy Rates ◽  
Clinical Pregnancy ◽  
Donor Sperm ◽  
Single Donor ◽  
Clinical Pregnancy Rates

scholarly journals Effects of Letrozole-HMG and Clomiphene-HMG on Incidence of Luteinized Unruptured Follicle Syndrome in Infertile Women Undergoing Induction Ovulation and Intrauterine Insemination: A Randomised Trial

2015 ◽  
Vol 8 (4) ◽  
pp. 244 ◽  
Author(s):  
Azra Azmoodeh ◽  
Mansoureh Pejman Manesh ◽  
Firouzeh Akbari Asbagh ◽  
Azizeh Ghaseminejad ◽  
Zeinab Hamzehgardeshi
Keyword(s):  
Menstrual Cycle ◽  
Endometrial Thickness ◽  
Intrauterine Insemination ◽  
Clomiphene Citrate ◽  
Randomised Trial ◽  
Induction Of Ovulation ◽  
Infertile Women ◽  
Significant Difference ◽  
Preovulatory Follicles ◽  
Luteinized Unruptured Follicle

<p><strong>BACKGROUND: </strong>Luteinized unruptured follicle (LUF) syndrome is considered a cause of ovulation failure and a subtle cause of infertility. Preovulatory injection of human chorionic gonadotropin (HCG) prevents or treats LUF syndrome, but it has also occurred after the induction of ovulation with clomiphene/HMG and HCG. This study was designed for evaluation and comparison of LUF incidence in eligible infertile women undergoing two stimulation protocols (clomiphene + HMG<strong> </strong>and letrozole + HMG) in addition to intrauterine insemination (IUI). Some related factors were compared between LUF and non-LUF cycles as secondary outcomes.</p> <p><strong>METHODS:</strong> The study was designed as a prospective randomized controlled trial. Patients were randomized using a table of random numbers into two equal protocol groups.<strong> </strong>For group A, (n = 90) clomiphene citrate was administrated orally in doses of 100 mg/day, and group B (n = 90) orally received letrozole 5 mg/day from day 3 to 7 of the menstrual cycle. Then HMG 75IU/day was administered intramuscularly in both groups on day 8 of the menstrual cycle and the dose was adjusted on the basis of ovarian response. The optimum size of preovulatory follicles for the injection of HCG (10,000 IU) was considered 18–23 mm. The number and size of preovulatory follicles were assessed by vaginal ultrasound 12 h before HCG (D0). Endometrial thickness was measured as well. IUI was performed on all patients 38–40 h after HCG. The second ultrasound examination was performed to observe the evidence of oocyte releasing at the time of IUI (D1). If the follicles were unruptured,<strong> </strong>a<strong> </strong>third sonography was performed on day 7 after HCG (D7) to observe LUF syndrome.</p> <p><strong>RESULTS: </strong>There was a significant difference between clomiphene-HMG and letrozole-HMG in LUF (p = 0.021) and pregnancy (p = 0.041). The complete LUF in letrozole-HMG was lower than the alternative group and the pregnancy rate was higher. The patients in the non-LUF group had higher midluteal progesterone and a thicker endometrium compared to LUF cycles (p = 0.039) and (p &lt; 0.001). The results of our multivariate logistic regression indicate that size 18–19.9 mm leads to the complete LUF  less than ≥22 mm [AOR: 0.25, P = 0.005], and  in size 20– 21.9 mm  as well [AOR: 0.17, P = 0.002].</p> <p><strong>CONCLUSION: </strong>Letrozole, with lower incidences of LUF, is more effective than clomiphene citrate for the induction of ovulation in IUI cycles. In our study, we illustrated that larger follicles of ≥22 mm diameter were associated with higher incidences of LUF. We recommend that further studies investigate and focus on the relationship between follicular size and/or full hormonal profiles and LUF.<strong></strong></p>

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