Cyclotron production, radiochemical separation and quality control of platinum radiotracers for toxicological studies

1998 ◽  
Vol 236 (1-2) ◽  
pp. 159-164 ◽  
Author(s):  
M. Bonardi ◽  
C. Birattari ◽  
M. Gallorini ◽  
F. Groppi ◽  
D. Arginelli ◽  
...  
Keyword(s):  
Quality Control ◽  
Radiochemical Separation ◽  
Cyclotron Production ◽  
Toxicological Studies

scholarly journals 122Sb - a potential radiotracer: Evaluation of cyclotron production via novel routes

2011 ◽  
Vol 26 (1) ◽  
pp. 58-63 ◽  
Author(s):  
Milad Enferadi ◽  
Mahdi Sadeghi
Keyword(s):  
Nuclear Reaction ◽  
Environmental Contamination ◽  
Radiochemical Separation ◽  
Half Life ◽  
Extraction Methods ◽  
Liquid Extraction ◽  
Food Crops ◽  
Cyclotron Production ◽  
Liquid Liquid Extraction ◽  
Existing Data

Antimony-122, having a half-life of 2.723 d and I?-=97.59%, is an important radiotracer in studies of environmental contamination and food crops. For the work discussed in this paper, the production of 122Sb was done via the natSn(p, xn)122Sb nuclear reaction. Radiochemical separation was performed by silica gel column chromatography and liquid-liquid extraction methods. Excitation functions for the 122Sb radionuclide, via 122Sn(p, n)122Sb, natSn(p, xn)122Sb, 122Sn(d, 2n)122Sb, natSn(d, xn)122Sb, 124Sn(p, 3n)122Sb and 124Sn(d, 4n)122Sb reactions, were calculated by ALICE/91, ALICE/ASH, and TALYS-1.2 codes and compared with existing data.

scholarly journals QUANTITATIVE DETERMINATION AND PREPARATIVE ISOLATION OF TWO MAJOR ALKALOIDS FROM THE VIETNAMESE MEDICINAL HERB EVODIAE FRUCTUS

2019 ◽  
pp. 26-32
Author(s):  
N. VAN T. NGUYEN ◽  
X. DAO T. NGUYEN ◽  
K. NGAN H. NGUYEN ◽  
T. KIEN NGUYEN ◽  
M. PHUONG NGUYEN ◽  
...  
Keyword(s):  
Quality Control ◽  
Mobile Phase ◽  
Fruit Size ◽  
Alkaloid Content ◽  
Spearman Correlation ◽  
Open Mouth ◽  
Toxicological Studies ◽  
One Step ◽  
Alkaloid Contents

Objective: To develop a simple and accurate HPLC-DAD method for simultaneous determination, the content of major components: limonin, evodiamine, and rutaecarpine in Evodiae fructus and evaluation the quality of Evodiae fructus sold in markets. Methods: Open column chromatography was used to separate and purify rutaecarpine and evodiamine, the two major alkaloids from Evodiae fructus extract as a laboratory standard. Chromatographic separation was achieved using a Germini C18 column (150 mm × 4.6 mm I.D., 5 µm), detected at 210 nm. The mobile phase consisted of acetonitrile (A), methanol (B), and water (C). The validated method simultaneously determined alkaloid content in 40 batches of samples collected from markets in different regions of Vietnam. Results: In one-step purification, our method yielded 326 mg of rutaecarpine and 128 mg of evodiamine from 3.2 g of crude extract, with purities of 98.9 and 98.5%, respectively. The structures of these compounds were identified using 1H NMR and 13C NMR. There was a significant correlation between alkaloid content and fruit size, with a Spearman correlation coefficient of>0.5 (p<0.001), and there was a large difference in alkaloid contents between three maturity degrees of the fruit. Open-mouth fruits and fruits with average sizes of 4 to 6 mm had the highest alkaloid contents, whereas closed-mouth fruits had the lowest. Conclusion: This study provided information on the standardization and quality control of evodiamine and rutaecarpine in Evodiae fructus, as well as a foundation for further pharmacological and toxicological studies.

scholarly journals Cyclotron production and radiochemical separation of 55Co and 58mCo from 54Fe, 58Ni and 57Fe targets

2017 ◽  
Vol 130 ◽  
pp. 90-101 ◽  
Author(s):  
H.F. Valdovinos ◽  
R. Hernandez ◽  
S. Graves ◽  
P.A. Ellison ◽  
T.E. Barnhart ◽  
...  
Keyword(s):  
Radiochemical Separation ◽  
Cyclotron Production

Metallobiochemistry of current environmental levels of trace metals: A new method of cyclotron production of48V for toxicological studies

1989 ◽  
Vol 134 (1) ◽  
pp. 199-208 ◽  
Author(s):  
E. Sabbioni ◽  
M. Bonardi ◽  
G. Tanet ◽  
Li Da-Kang ◽  
M. Gallorini ◽  
...  
Keyword(s):  
Trace Metals ◽  
New Method ◽  
Cyclotron Production ◽  
Toxicological Studies

Ultrastructural investigations of MDL 19,660-induced effects on the canine platelet and megakaryocyte

1990 ◽  
Vol 48 (3) ◽  
pp. 374-375
Author(s):  
D.E. Loudy ◽  
J. Sprinkle-Cavallo ◽  
J.T. Yarrington ◽  
F.Y. Thompson ◽  
J.P. Gibson
Keyword(s):  
Antidepressant Drug ◽  
Beagle Dogs ◽  
Long Term Effects ◽  
Short Term ◽  
Platelet Counts ◽  
Toxicological Studies ◽  
Induced Aggregation ◽  
Internal Architecture

Previous short term toxicological studies of one to two weeks duration have demonstrated that MDL 19,660 (5-(4-chlorophenyl)-2,4-dihydro-2,4-dimethyl-3Hl, 2,4-triazole-3-thione), an antidepressant drug, causes a dose-related thrombocytopenia in dogs. Platelet counts started to decline after two days of dosing with 30 mg/kg/day and continued to decrease to their lowest levels by 5-7 days. The loss in platelets was primarily of the small discoid subpopulation. In vitro studies have also indicated that MDL 19,660: does not spontaneously aggregate canine platelets and has moderate antiaggregating properties by inhibiting ADP-induced aggregation. The objectives of the present investigation of MDL 19,660 were to evaluate ultrastructurally long term effects on platelet internal architecture and changes in subpopulations of platelets and megakaryocytes.Nine male and nine female beagle dogs were divided equally into three groups and were administered orally 0, 15, or 30 mg/kg/day of MDL 19,660 for three months. Compared to a control platelet range of 353,000- 452,000/μl, a doserelated thrombocytopenia reached a maximum severity of an average of 135,000/μl for the 15 mg/kg/day dogs after two weeks and 81,000/μl for the 30 mg/kg/day dogs after one week.

The role of the ubiquitin–proteasome system in ER quality control

2005 ◽  
Vol 41 (1) ◽  
pp. 99 ◽  
Author(s):  
Yihong Ye
Keyword(s):  
Quality Control ◽  
Ubiquitin Proteasome System ◽  
Er Quality Control ◽  
Ubiquitin Proteasome
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