Roxithromycin 150 mg b.i.d. versus amoxycillin 500 mg/clavulanic acid 125 mg t.i.d. for the treatment of lower respiratory tract infections in general practice

Infection ◽  
1995 ◽  
Vol 23 (S1) ◽  
pp. S15-S20 ◽  
Author(s):  
N. C. Karalus ◽  
J. E. Garrett ◽  
S. D. R. Lang ◽  
R. A. Leng ◽  
G. N. Kostalas ◽  
...  
Keyword(s):  
General Practice ◽  
Respiratory Tract ◽  
Clavulanic Acid ◽  
Lower Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Lower Respiratory Tract Infections ◽  
Tract Infections

Treatment of Lower Respiratory Tract Infections with Amoxycillin/Clavulanic Acid in Adults

1993 ◽  
Vol 21 (2) ◽  
pp. 98-101 ◽  
Author(s):  
G Tatsis ◽  
M Veslemes ◽  
C Hadjistavrou ◽  
A Votsiou ◽  
J Jordanoglou
Keyword(s):  
Respiratory Tract ◽  
Clavulanic Acid ◽  
Lower Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Adverse Side Effect ◽  
Lower Respiratory Tract Infections ◽  
Acute Exacerbations ◽  
Sputum Volume ◽  
Chest X Ray ◽  
Tract Infections

Patients with lower respiratory tract infections [pneumonia ( n = 16), bronchiectasis ( n = 5) and acute exacerbations of chronic bronchitis ( n = 44)] were treated daily with amoxycillin/clavulanic acid given either 1.2 g intravenously three times daily or 625 mg orally three times daily for 7–15 days. Symptoms, signs and sputum volume and colour were monitored daily. Chest X-ray, sputum culture and Gram-stain examinations were also carried out on days 1 and 5, and immediately after the end of the treatment. There was a clinical improvement, as indicated by the incidence of cough, dyspnoea and rales, and by sputum volume and colour in 90.8% of the patients. Microbiological improvement, as indicated by the complete elimination of sputum pathogens and pus cells, was achieved in the same proportion of patients (90.8%). In one patient, an adverse side-effect, diffuse exanthema, was noted. Amoxycillin/clavulanic acid possesses a high clinical and microbiological efficacy for lower respiratory tract infections.

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