Neuronal mechanisms of site-specific nociceptive sensitization in the common snail

1999 ◽  
Vol 29 (2) ◽  
pp. 167-173 ◽  
Author(s):  
V. P. Nikitin ◽  
S. A. Kozyrev

1996 ◽  
Vol 26 (5) ◽  
pp. 468-476 ◽  
Author(s):  
V. P. Nikitin ◽  
S. A. Kozyrev




1998 ◽  
Vol 28 (5) ◽  
pp. 547-555 ◽  
Author(s):  
A. V. Shevelkin ◽  
V. P. Nikitin ◽  
S. A. Kozyrev ◽  
M. O. Samoilov ◽  
V. V. Sherstnev


2020 ◽  
Vol 64 (1) ◽  
pp. 135-153 ◽  
Author(s):  
Lauren Elizabeth Smith ◽  
Adelina Rogowska-Wrzesinska

Abstract Post-translational modifications (PTMs) are integral to the regulation of protein function, characterising their role in this process is vital to understanding how cells work in both healthy and diseased states. Mass spectrometry (MS) facilitates the mass determination and sequencing of peptides, and thereby also the detection of site-specific PTMs. However, numerous challenges in this field continue to persist. The diverse chemical properties, low abundance, labile nature and instability of many PTMs, in combination with the more practical issues of compatibility with MS and bioinformatics challenges, contribute to the arduous nature of their analysis. In this review, we present an overview of the established MS-based approaches for analysing PTMs and the common complications associated with their investigation, including examples of specific challenges focusing on phosphorylation, lysine acetylation and redox modifications.



1965 ◽  
Vol s3-106 (73) ◽  
pp. 3-13
Author(s):  
JOHN R. BAKER ◽  
ELIZABETH G. M. WILLIAMS

The cation of methyl green carriea two poaitive charges, that of malachite green only one; but the two dyes behave towards tissue-constituents in almost exactly the same way. These dyes are not specific for chromatin. They colour certain objects that are devoid of DNA, even when they are used in very dilute solution. The granules of cells called Körnchenzellen in the connective tissue of the common snail, Helix aspersa, are strongly coloured by both dyes from very dilute solutions, and thus provide a striking instance of the unspecificity of these dyes. Malachite green, which is stable and free from contamination by metachromstic impurities, can advantageously replace the methyl green commonly used in mixtures with pyronine. It is suggested that pyronine may have a greater capacity for penetrating into close-textured objects, such ss nucleoli and ribosomes, than methyl and malachite greens.



1994 ◽  
Vol 24 (6) ◽  
pp. 507-512 ◽  
Author(s):  
Yu. V. Burov ◽  
E. I. Drozdova ◽  
A. S. Pivovarov ◽  
T. N. Robakidze
Keyword(s):  


Nature ◽  
1879 ◽  
Vol 20 (511) ◽  
pp. 363-363 ◽  
Author(s):  
JAMES WARD
Keyword(s):  


1991 ◽  
Vol 69 (4) ◽  
pp. 988-994 ◽  
Author(s):  
Patrick T. Gregory ◽  
Kari J. Nelson

Diets of garter snakes (Thamnophis) often vary in space or time in response to variations in prey abundance. We compared the diet of the common garter snake (T. sirtalis) on Vancouver Island at fish-rearing facilities (hatcheries) and at nearby natural sites where fish were present but less abundant. Snakes of all sizes fed on fish at hatcheries, but fish were rarely eaten at natural sites, where amphibians or earthworms were the major prey types. Any particular characterization of the diet of this species therefore must be site specific. Although snakes exhibited intersite variation in diet, there was no evidence of temporal variation in diet at any site. The proportion of snakes with food in their stomachs varied among sites (perhaps indicating differences in frequency of feeding among sites) and was correlated with mean relative body mass of snakes. This suggests that some sites are more productive than others for snakes, but rigorous tests of whether snake populations are food-limited have not been done.





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