Development and validation of an reversed-phase liquid chromatographic method for analysis of spiramycin and related substances

2001 ◽  
Vol 54 (1-2) ◽  
pp. 51-56 ◽  
Author(s):  
H. K. Chepkwony ◽  
A. Vermaelen ◽  
E. Roets ◽  
J. Hoogmartens
Keyword(s):  
Chromatographic Method ◽  
Reversed Phase ◽  
Related Substances ◽  
Liquid Chromatographic Method ◽  
Phase Liquid ◽  
Development And Validation ◽  
Liquid Chromatographic

scholarly journals Development and Validation of Liquid Chromatographic Method for Estimation of Ibuprofen and Famotidine in Combined Dosage Form

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Dimal A. Shah ◽  
Dixita J. Suthar ◽  
Sunil L. Baldania ◽  
Usman K. Chhalotiya ◽  
Kashyap K. Bhatt
Keyword(s):  
Mobile Phase ◽  
Dosage Form ◽  
Chromatographic Method ◽  
Reversed Phase ◽  
Assay Method ◽  
Liquid Chromatographic Method ◽  
Phase Liquid ◽  
Development And Validation ◽  
Liquid Chromatographic

An isocratic, reversed phase-liquid-chromatographic assay method was developed for the quantitative determination of ibuprofen and famotidine in combined-dosage form. A Brownlee C18, 5 μm column with mobile phase containing water : methanol : acetonitrile (30 : 60 : 10, v/v/v) was used. The flow rate was 1.0 mL/min, and effluents were monitored at 264 nm. The retention times of ibuprofen and famotidine were 4.9 min and 6.8 min, respectively. The linearity for ibuprofen and famotidine was in the range of 2–20 μg/mL and 0.1–10 μg/mL, respectively. The proposed method was validated with respect to linearity, accuracy, precision, specificity, and robustness. The method was successfully applied to the estimation of ibuprofen and famotidine in combined dosage form.

Development and validation of a reversed phase liquid chromatographic method with fluorescence detection for the pharmacokinetic study of a new chimeric peptide

2016 ◽  
Vol 8 (12) ◽  
pp. 2620-2627 ◽  
Author(s):  
Xiaoyun Zhang ◽  
Ying Chen ◽  
Lin Li ◽  
Hua Qiao ◽  
Rui Wang ◽  
...  
Keyword(s):  
Fluorescence Detection ◽  
Pharmacokinetic Study ◽  
Chromatographic Method ◽  
Reversed Phase ◽  
Chimeric Peptide ◽  
Liquid Chromatographic Method ◽  
Phase Liquid ◽  
Development And Validation ◽  
Liquid Chromatographic

HPLC-FLD was validated and employed in the pharmacokinetic study of FITC-BN-9 in rats.

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