Organothallium compounds. Study of the iodination of dibutylthallium salts by molecular iodine in dioxane

1997 ◽  
Vol 46 (12) ◽  
pp. 2130-2134 ◽  
Author(s):  
I. F. Gun'kin ◽  
E. V. Finaenova
Keyword(s):  
Molecular Iodine ◽  
Organothallium Compounds

Molecular iodine synergized and sensitized neuroblastoma cells to the antineoplastic effect of ATRA

2020 ◽  
Vol 27 (12) ◽  
pp. 699-710
Author(s):  
Irasema Mendieta ◽  
Gabriel Rodríguez-Gómez ◽  
Bertha Rueda-Zarazúa ◽  
Julia Rodríguez-Castelán ◽  
Winniberg Álvarez-León ◽  
...  
Keyword(s):  
Residual Disease ◽  
Neuroblastoma Cells ◽  
Survivin Expression ◽  
Body Weight Loss ◽  
Immunohistochemical Analysis ◽  
Molecular Iodine ◽  
Tyrosine Kinase Receptor ◽  
Adjuvant Effect

Neuroblastoma (NB) is the most common solid childhood tumor, and all-trans retinoic acid (ATRA) is used as a treatment to decrease minimal residual disease. Molecular iodine (I2) induces differentiation and/or apoptosis in several neoplastic cells through activation of PPARγ nuclear receptors. Here, we analyzed whether the coadministration of I2 and ATRA increases the efficacy of NB treatment. ATRA-sensitive (SH-SY5Y), partially-sensitive (SK-N-BE(2)), and non-sensitive (SK-N-AS) NB cells were used to analyze the effect of I2 and ATRA in vitro and in xenografts (Foxn1 nu/nu mice), exploring actions on cellular viability, differentiation, and molecular responses. In the SH-SY5Y cells, 200 μM I2 caused a 100-fold (0.01 µM) reduction in the antiproliferative dose of ATRA and promoted neurite extension and neural marker expression (tyrosine hydroxylase (TH) and tyrosine kinase receptor alpha (Trk-A)). In SK-N-AS, the I2 supplement sensitized these cells to 0.1 μM ATRA, increasing the ATRA-receptor (RARα) and PPARγ expression, and decreasing the Survivin expression. The I2 supplement increased the mitochondrial membrane potential in SK-N-AS suggesting the participation of mitochondrial-mediated mechanisms involved in the sensibilization to ATRA. In vivo, oral I2 supplementation (0.025%) synergized the antitumor effect of ATRA (1.5 mg/kg BW) and prevented side effects (body weight loss and diarrhea episodes). The immunohistochemical analysis showed that I2 supplementation decreased the intratumoral vasculature (CD34). We suggest that the I2 + ATRA combination should be studied in preclinical and clinical trials to evaluate its potential adjuvant effect in addition to conventional treatments.

Organic Domino Reactions Catalyzed by Molecular Iodine

2012 ◽  
Vol 1 (2) ◽  
pp. 137-158 ◽  
Author(s):  
Gunasekar Ramachandran ◽  
Kulathu Sathiyanarayanan
Keyword(s):  
Molecular Iodine ◽  
Domino Reactions

Antiproliferative Effects of Molecular Iodine in Cancers

2011 ◽  
Vol 5 (3) ◽  
pp. 168-176
Author(s):  
Pompilio Elio Torremante ◽  
Harald Rosner
Keyword(s):  
Molecular Iodine ◽  
Antiproliferative Effects

Radical polymerization of butadiene mediated by molecular iodine: a kinetic study of solution homopolymerization

2021 ◽  
Vol 28 (8) ◽  
Author(s):  
Mahdi Abdollahi ◽  
Masoud Akbari Hajiataloo
Keyword(s):  
Kinetic Study ◽  
Radical Polymerization ◽  
Molecular Iodine

ChemInform Abstract: One-Pot Four-Component Domino Reaction for the Synthesis of Substituted Dihydro-2-oxypyrrole Catalyzed by Molecular Iodine.

ChemInform ◽  
2012 ◽  
Vol 43 (36) ◽  
pp. no-no
Author(s):  
Abu T. Khan ◽  
Arindam Ghosh ◽  
Md. Musawwer Khan
Keyword(s):  
Molecular Iodine ◽  
Domino Reaction ◽  
One Pot

Thermal Isotropic Exchange between Ethyl Iodide and Molecular Iodine in the Liquid Phase

1957 ◽  
Vol 61 (1) ◽  
pp. 111-112 ◽  
Author(s):  
L. R. Darbee ◽  
G. M. Morris
Keyword(s):  
Liquid Phase ◽  
Molecular Iodine ◽  
Ethyl Iodide ◽  
Isotropic Exchange
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