Effects of the serotonin-antagonist ketanserin on the function of ischaemic and normally perfused myocardium and modification by β-1-blockade in anaesthetized normotensive dogs

1992 ◽  
Vol 192 (1) ◽  
pp. 355-365
Author(s):  
H. Schad ◽  
W. Heimisch ◽  
A. Barankay ◽  
S. Hesse ◽  
N. Mendler
Keyword(s):  
Serotonin Antagonist

Depression of Collateral Blood Flow Following Arterial Thrombosis

1977 ◽  
Vol 38 (04) ◽  
pp. 0850-0862 ◽  
Author(s):  
Robert G. Schaub ◽  
Ronald Sande ◽  
Kenneth M. Meyers
Keyword(s):  
Blood Flow ◽  
Arterial Thrombosis ◽  
Hind Limb ◽  
Therapeutic Interventions ◽  
Collateral Blood Flow ◽  
Serotonin Antagonist ◽  
Limb Perfusion ◽  
Clinical Consequences ◽  
Collateral Vessels ◽  
Iliac Bifurcation

SummaryPermanent ligation of the feline aorta at the iliac bifurcation is followed by rapid opening of pre-existing collateral blood vessels. However, if ligation is combined with formation of a clot, these protective collateral vessels do not function. This study was undertaken to determine if drugs which alter serotonin function can improve collateral blood flow after arterial thrombosis. Permanent ligations were placed at the iliac bifurcation, circumflex iliac and sixth lumbar arteries in all cats. A clot was produced in the aorta of 27 cats by injection of 0.1 ml of thromboplastin. Ligated clot-occluded cats were untreated (10); had blood serotonin depleted using a single dose of reserpine (0.1 mg/kg i. m.) followed by para-chlorophenylanine (p-CPA) (100 mg/kg orally) every 3 days (9) ; or were treated prior to surgery with a serotonin antagonist cinanserin HC1 (4 mg/kg i. v.) (8). Control cats (18) were acutely ligated. 9 of these cats were untreated, 5 were cinanserin HC1-treated, and 4 were reserpine/p-CPA-treated. Extent of collateral development was assessed by aortograms 3 days after occlusion and by neurologic rating. Aortograms of acutely ligated cats indicated a significant collateral blood flow around the segment of ligated aorta, while ligated clot-occluded cats had a severely depressed hind-limb perfusion. Reserpine/p-CPA-treated ligation clot-occluded cats had aortograms similar to acutely ligated cats. The cinanserin HC1-treated ligation clot-occluded cats had aortograms which indicated hind-limb perfusion was not as adequate as the acutely ligated cats. However, the perfusion of these animals was improved over untreated ligation clot-occluded cats. Neurologic rating correlated with aortograms. These results suggest: 1) the clinical consequences of arterial thrombosis cannot be entirely attributed to mechanical occlusion of an artery, but may be due to depression of protective collateral blood flow induced by thrombosis, 2) serotonin is an important factor in this depression of collateral blood flow, and 3) isolation of the factors responsible for collateral inhibition could permit the development of therapeutic interventions.

Influence of Certain Drugs on the Adhesiveness of Human, Rat, and Rabbit Blood Platelets in Vitro

1965 ◽  
Vol 13 (02) ◽  
pp. 428-438 ◽  
Author(s):  
K Reber ◽  
A Studer
Keyword(s):  
Sodium Citrate ◽  
Blood Platelets ◽  
Drug Application ◽  
Normal Range ◽  
Blood Samples ◽  
Serotonin Antagonist ◽  
Thrombocyte Count ◽  
Particle Count ◽  
Rabbit Blood

SummaryThis is a comparative study of the methods described by H. P. Wright and O’Brien for determining the adhesiveness of thrombocytes. An attempt is made to characterize and statistically correlate both techniques. With the aid of a Coulter Counter for thrombocyte counts, a normal range is presented for human, rat, and rabbit blood. Anticoagulants used are sodium citrate and Heparin.The influence of Cocaine and the Serotonin antagonist Ro 3-0837 was studied on these same substrates, to determine a pharmacological interference with results of either Wright’s test or O’Brien’s. Both drugs are found to induce a statistically significant increase in the “thrombocyte count” as compared to the corresponding controls. These effects are not real but to be attributed to an increase in particle count due to thrombocyte fragmentation as a consequence of drug application. There is no evidence for the claim that these drugs decrease the adhesiveness of thrombocytes.Numerical results of both tests often show a high and statistically significant correlation, especially following the addition of Ro 3-0837. Such is not true of individual blood samples to which no drug has been added. Evidentally, both tests are not specific for the same characteristic of normal blood platelets. But, when Ro 3-0837 is added, the breakdown of unstable platelets is induced; and the corresponding increase in count of thrombocyte fragments is expressed by both tests in the same fashion.

Comparison of the 5-Hydroxytryptamine3(Serotonin) Antagonist Ondansetron (Gr 38032F) with High-Dose Metoclopramide in the Control of Cisplatin-Induced Emesis

1990 ◽  
Vol 322 (12) ◽  
pp. 816-821 ◽  
Author(s):  
Michel Marty ◽  
Pierre Pouillart ◽  
Susy Scholl ◽  
Jean Pierre Droz ◽  
Mohamed Azab ◽  
...  
Keyword(s):  
High Dose ◽  
Serotonin Antagonist

scholarly journals C-027 Inhibits IgE-mediated passive sensitization bronchoconstriction and acts as a histamine and serotonin antagonist in human airways

2011 ◽  
Vol 32 (5) ◽  
pp. 359-365 ◽  
Author(s):  
Philip R. Cooper ◽  
Jie Zhang ◽  
Gautam Damera ◽  
Toshinori Hoshi ◽  
David A. Zopf ◽  
...  
Keyword(s):  
Serotonin Antagonist ◽  
Passive Sensitization ◽  
Ige Mediated ◽  
Human Airways

Duodenal acid-induced gastric relaxation is mediated by multiple pathways

1999 ◽  
Vol 276 (6) ◽  
pp. G1501-G1506 ◽  
Author(s):  
Yuan-Xu Lu ◽  
Chung Owyang
Keyword(s):  
Gastric Motility ◽  
No Reduction ◽  
Direct Action ◽  
Intragastric Pressure ◽  
Afferent Pathways ◽  
Serotonin Antagonist ◽  
Intraduodenal Infusion ◽  
Rate Dependent ◽  
Vagal Afferent

In this study, we used an in vivo anesthetized rat model to investigate the mechanisms responsible for duodenal acid-induced inhibition of gastric motility. Intraduodenal infusion of HCl produced a rate-dependent decrease in intragastric pressure. Infusion of HCl at 2 ml/h produced a physiological plasma secretin level and elicited a decrease in intragastric pressure of 3.0 ± 0.2 cmH20. Infusion of rabbit secretin antiserum reduced the acid-induced inhibition of gastric motility by 85 ± 5%, suggesting mediation mainly by endogenous secretin. Administration of the cholecystokinin (CCK)-A antagonist MK-329 caused only a modest 10 ± 3% reduction in gastric relaxation, whereas the serotonin antagonist ICS-205930 had no effect. In contrast, immunoneutralization with the secretin antibody caused only a 15% reduction in the relaxation evoked by a higher rate of HCl infusion (3 ml/h), whereas MK-329 and ICS-205930 caused a 20 ± 4% reduction and no reduction, respectively. Bilateral truncal vagotomy or perivagal application of capsaicin completely abolished gastric relaxation in response to low rates (1–2 ml/h) of 0.1 N HCl infusion but only partially affected gastric relaxation in response to a higher infusion rate (3 ml/h). These observations indicate that multiple pathways mediate the duodenal acid-induced inhibition of gastric motility. At low rates of HCl infusion, gastric relaxation is mediated primarily by endogenous secretin, which acts through vagal afferent pathways. At higher rates of HCl infusion, gastric relaxation is mediated by endogenous secretin, CCK, and possibly by the direct action of HCl on vagal afferent pathways or yet unidentified neuropathways.

Serotonin antagonist pirenperone inhibits sexual behavior in the male rat: Attenuation by quipazine

1985 ◽  
Vol 22 (4) ◽  
pp. 565-571 ◽  
Author(s):  
Scott D. Mendelson ◽  
Boris B. Gorzalka
Keyword(s):  
Sexual Behavior ◽  
Male Rat ◽  
Serotonin Antagonist

The Influence of Ritanserin, a Serotonin Antagonist, in Anxiety Disorders: A Double-blind Placebo-controlled Study versus Lorazepam

1985 ◽  
Vol 18 (05) ◽  
pp. 303-305 ◽  
Author(s):  
D. Ceulemans ◽  
M.-L. Hoppenbrouwers ◽  
Y. Gelders ◽  
A. Reyntjens
Keyword(s):  
Anxiety Disorders ◽  
Controlled Study ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Serotonin Antagonist

scholarly journals Фармакотерапевтична ефективність перитолу та водорозчинного аспірину у лікуванні поросят, хворих на гастроентерит

2015 ◽  
pp. 103-108
Author(s):  
П. П. Шатохін ◽  
К. В. Супруненко ◽  
Л. П. Каришева
Keyword(s):  
Antioxidant System ◽  
Serotonin Antagonist ◽  
Treatment Regimens

Розглянуто питання лікування поросят відлучноговіку хворих на гастроентерит. Метою нашого дослід-ження було застосування в комплексному лікуванніхворих поросят препаратів, а саме: антагоністасеротоніну – перитолу та препарату з групи саліци-латів – водорозчинну форму ацетилсаліцилової кис-лоти [15]. Встановлено, що препарати, які ми за-стосовували, виявляють різнобічну дію на організмпоросят, зокрема на показники еритропоезу, деякіпоказники антиоксидантної системи та концентра-цію тіреоїдних гормонів. За результатами дослідіввизначено терапевтичну ефективність запропонова-них нами схем лікування. We dealed with a subject of piglets'gastroenteritis treatment. The aim of our study wasANNOTATIONS№ 3 • 2015 • ВІСНИК Полтавської державної аграрної академії 207to use in the treatment of patients pigletspreparations, namely serotonin antagonist – peritoland drugs from the group of salicylates – watersoluble form of aspirin. It was established that thedrugs we used exhibit diverse effects on the pigs, inparticular, on the performance of erythropoiesis,some indicators of antioxidant system and thyroidconcentration of hormones. According to the resultsof experiments determined the therapeutic efficacyof our proposed treatment regimens.

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