Concerning the way to study the relative potencies of bronchodilator agents in vitro

Lung ◽  
1986 ◽  
Vol 164 (1) ◽  
pp. 303-305
Author(s):  
Jan A. M. Raaijmakers ◽  
Rea J. van Rozen
Keyword(s):  
Bronchodilator Agents ◽  
Relative Potencies ◽  
The Way

Anticoagulant Properties of Three Mucopolysaccharides Used in Rheumatology

1983 ◽  
Vol 50 (03) ◽  
pp. 652-655 ◽  
Author(s):  
F Bauer ◽  
P Schulz ◽  
G Reber ◽  
C A Bouvier
Keyword(s):  
Factor Xa ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Thrombin Time ◽  
Coagulation Tests ◽  
Amplification System ◽  
Relative Potencies ◽  
In Vivo Administration

SummaryThree mucopolysaccharides (MPS) used in the treatment of degenerative joint disease were compared to heparin to establish their relative potencies on 3 coagulation tests, the aPTT, the antifactor X a activity and the dilute thrombin time. One of the compounds, Arteparon®, was one fourth as potent as heparin on the aPTT, but had little or no influence on the 2 other tests. Further in vitro studies suggested that Arteparon® acted at a higher level than factor Xa generation in the intrinsic amplification system and that its effect was independent of antithrombin III. In vivo administration of Arteparon® confirmed its anticoagulant properties, which raises the question of the clinical use of this MPS.

New Imidazole Inhibitors of Mycobacterial FtsZ: the Way from High-Throughput Molecular Screening in Grid up to in vitro Verification

2016 ◽  
Vol 12 (3) ◽  
pp. 43-55 ◽  
Author(s):  
P.A. Karpov ◽  
◽  
O.M. Demchuk ◽  
V.M. Britsun ◽  
D.I. Lytvyn ◽  
...  
Keyword(s):  
High Throughput ◽  
Molecular Screening ◽  
The Way

Effects of summer mailing on in vivo and in vitro relative potencies of standardized timothy grass extract

2010 ◽  
Vol 104 (2) ◽  
pp. 147-151 ◽  
Author(s):  
Meredith Moore ◽  
Mark Tucker ◽  
Tom Grier ◽  
James Quinn
Keyword(s):  
Timothy Grass ◽  
Relative Potencies

Meet me halfway: Are in vitro 3D cancer models on the way to replace in vivo models for nanomedicine development?

2021 ◽  
Author(s):  
Sabina Pozzi ◽  
Anna Scomparin ◽  
Sahar Israeli-Dangoor ◽  
Daniel Rodriguez ◽  
Paula Ofek ◽  
...  
Keyword(s):  
In Vivo Models ◽  
Cancer Models ◽  
The Way

In vitro effects of temperature on red blood cell deformability and membrane stability in human and various vertebrate species

2021 ◽  
pp. 1-10
Author(s):  
Adam Attila Matrai ◽  
Gabor Varga ◽  
Bence Tanczos ◽  
Barbara Barath ◽  
Adam Varga ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Whole Blood ◽  
Mechanical Stability ◽  
Cell Deformability ◽  
Blood Samples ◽  
Effects Of Temperature ◽  
The Way ◽  
Rbc Deformability

BACKGROUND: The effects of temperature on micro-rheological variables have not been completely revealed yet. OBJECTIVE: To investigate micro-rheological effects of heat treatment in human, rat, dog, and porcine blood samples. METHODS: Red blood cell (RBC) - buffer suspensions were prepared and immersed in a 37, 40, and 43°C heat-controlled water bath for 10 minutes. Deformability, as well as mechanical stability of RBCs were measured in ektacytometer. These tests were also examined in whole blood samples at various temperatures, gradually between 37 and 45°C in the ektacytometer. RESULTS: RBC deformability significantly worsened in the samples treated at 40 and 43°C degrees, more expressed in human, porcine, rat, and in smaller degree in canine samples. The way of heating (incubation vs. ektacytometer temperation) and the composition of the sample (RBC-PBS suspension or whole blood) resulted in the different magnitude of RBC deformability deterioration. Heating affected RBC membrane (mechanical) stability, showing controversial alterations. CONCLUSION: Significant changes occur in RBC deformability by increasing temperature, showing inter-species differences. The magnitude of alterations is depending on the way of heating and the composition of the sample. The results may contribute to better understanding the micro-rheological deterioration in hyperthermia or fever.

In vitro studies on the relative potency of bronchodilator agents

Lung ◽  
1985 ◽  
Vol 163 (1) ◽  
pp. 161-171 ◽  
Author(s):  
Joseph H. Fleisher ◽  
Jacob L. Pinnas
Keyword(s):  
In Vitro Studies ◽  
Relative Potency ◽  
Bronchodilator Agents

scholarly journals STRONGYLS BENZIMIDAZOLE RESISTANCE IN EQUINE FROM ZOO

2009 ◽  
Vol 15 (1) ◽  
pp. 63-68
Author(s):  
Mihai CERNEA ◽  
Cristina CERNEA
Keyword(s):  
Drug Resistance ◽  
Drug Combinations ◽  
Drug Resistant ◽  
Time Treatment ◽  
Benzimidazole Resistance ◽  
Baia Mare ◽  
Significant Pathology ◽  
The Way

The research in view of establishing the development and the way in which antihelmintical treatment influences epidemiological indexes, was carried out between October 2008 and May 2009 in equine species from zoos. In the zoo located Targu Mures it was noticed am strongyls intensity of 2300 EPG - 8700 LPG in horses, and 700 EPG - 1400 LPG in ponies. In vitro effectiveness of bemzimidazoles (BZ) being low in both horses and ponies. In the zoo located in Turda the intensity of the strongyl parasitism reached the level of 900 EPG - 2300 LPG in horses and 2400EPG - 2800 LPG in ponies, the effectiveness of the benzimidazoles being low. In the zoo located in Baia Mare the intensity of strongyls infestation was of 900 EPG - 1600 LPG in horses, 1900 EPG – 2600 LPG in ponies, 900 EPG -1500 LPG in donkeys benzimidazoles treatment being proven effective. Cyathostomum species are considered as having the most significant pathology in equines. Worldwide, anthelmintical treatment, especially in strongylatosis, faces an ever-increasing phenomenon of drug resistance, to phenotiazin, thiabendazole as well as other BZ and ProBZ, in the strongyls population. The lack of success in treatment using drug combinations (piperazin and phenotiazin; triclorfon and phenotiazin; diclorfos and morantel) have spurred the development of new substances to which strongyls have not developed resistance. Tong time treatment with the same substance leads to the development of drug-resistant strongyl population, thus a low effectiveness, below the desired level.

Cross-species comparison of relative potencies and relative sensitivities of fishes to dibenzo-p-dioxins, dibenzofurans, and polychlorinated biphenyls in vitro

2015 ◽  
Vol 35 (1) ◽  
pp. 173-181 ◽  
Author(s):  
Bryanna K. Eisner ◽  
Jon A. Doering ◽  
Shawn C. Beitel ◽  
Steve Wiseman ◽  
Jason C. Raine ◽  
...  
Keyword(s):  
Polychlorinated Biphenyls ◽  
Species Comparison ◽  
Relative Potencies ◽  
Cross Species Comparison

Influence of analogues of phenylbutazone on renal transport of 4-aminohippurate

1963 ◽  
Vol 205 (3) ◽  
pp. 489-493 ◽  
Author(s):  
Agamemnon Despopoulos ◽  
Lloyd H. Pendergrass ◽  
John M. Stoeckinger
Keyword(s):  
Molecular Structure ◽  
Pharmacological Activity ◽  
Transport Mechanism ◽  
Renal Transport ◽  
Inhibitory Potency ◽  
In Vitro Technique ◽  
Dog Kidney ◽  
Relative Potencies ◽  
Clearance Technique

Analogues of phenylbutazone were tested for inhibitory potency in the renal transport mechanism for 4-aminohippurate. In a series of ten compounds examined by an in vitro technique, no correlation could be demonstrated between inhibitory potency and acidic strength of the inhibitor either in rabbit or in dog tissues. In a further series of 16 paired analogues, the hydroxylated member of each pair was 3–4 times less potent than its unhydroxylated counterpart. Correlations between molecular structure and pharmacological activity are suggested. In contrast to these observations, each of three selected phenylbutazone analogues (phenylbutazone, metabolite II, and sulfinpyrazone) depressed the maximum tubular excretory rate for 4-aminohippurate in intact dogs, but apparent inhibitory potencies by the clearance technique were unrelated to inhibitory potencies in dog kidney slices. Differences in relative potencies thus obtained are attributed to differences in metabolic alteration of each compound at extrarenal sites in intact dogs.

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