Blood gases and acid-base balance in children with bronchial asthma

Lung ◽  
1978 ◽  
Vol 155 (1) ◽  
pp. 111-122 ◽  
Author(s):  
Ejvor Oberger ◽  
Inga Engström
2020 ◽  
pp. 565-571
Author(s):  
K.I. ISMOILOV ◽  
◽  
M.M. SHARIPOVA ◽  

Objective: To examine the acid-base balance, blood gases and echocardiographic changes in bronchial asthma in children. Methods: The results of the examination of 60 children suffering from bronchial asthma (BA), aged from 5 to 14 years are presented. The patients were divided into 2 groups depending on their age. The first group consisted of 28 children from 5 to 10 years old, the second – 32 children aged 11 to 14 years. The control group included 20 healthy children, identical to the surveyed groups in terms of gender and age. Echocardiography was performed on a Vivad 3 apparatus (GE, USA), the acid-base balance and blood gases were studied on an ABL 800 Flex apparatus (Radiometer Medical, Denmark). Results: Studies have shown that children with asthma had significant changes in the ventilation capacity of the lungs in the form of perfusion and diffusion disorders, which undoubtedly influenced the severity of their condition. In children of both groups, there was a significant lack of bases (p<0.001) and a decrease of pH average value in comparison with similar indicators of healthy children. A significant difference in BE and pH values was found between the two groups of patients (p<0.01). The main changes in hemodynamics were reflected in the indicators of TV A and TV E/A. As in children under 10 years of age with BA, and in children over 10 years of age with BA, TV A was higher than in children of the control group (0.48±0.02 versus 0.38±0.02 (p<0.05) and 0.59±0.02 versus 0.49±0.02 (p<0.05) respectively), while the TV E/A ratio was lower in children with BA (1.22±0.03 versus 1.42±0.05 (p<0.05) and 1.31±0.04 versus 1.59±0.06 (p<0.05) respectively). Conclusions: It was found that third patients in the interictus period of the disease have mild hypoxemia, which, as a rule, is combined with a drop in the alveolar-arterial O2 gradient. The examined patients were characterized by respiratory acidosis. The detected echocardiographic changes confirmed the presence of myocardial dystrophy and the development of «cor pulmonale» in 2 children of the second group with more than 6 years and occurring frequent exacerbations. Keywords: Bronchial asthma, children, heart, echocardiography, acid-base balance, blood gases.


PEDIATRICS ◽  
1970 ◽  
Vol 46 (5) ◽  
pp. 730-736
Author(s):  
Katherine H. Halloran ◽  
Steven C. Schimpff ◽  
Jean G. Nicolas ◽  
Norman S. Talner

Tolerance to acetyl strophanthidin, a rapid-acting cardiac aglycone, was determined in 28 anesthetized mongrel puppies, ages 16 to 56 days, and compared to tolerance in 16 littermate puppies in whom acute hypercapnic acidemia was produced. The tolerance was also compared to that of four adult mongrel dogs. The toxic dose was defined as the intravenous amount required to produce four consecutive premature ventricular contractions. A marked variation in the toxic dose was found in the 28 control puppies (range 83 to 353 µg/kg, mean 169 µg/kg) which could not be correlated with age, arterial blood gases or pH, serum potassium or sodium, arterial pressure, or heart rate. The toxic dose was significantly greater in the puppies than in the adult dogs, in whom the mean toxic dose was 64 µg/kg (range 50 to 89 µg/kg). A significant increase in tolerance was also observed in the puppies with hypercapnic acidemia (mean toxic dose 220 µg/kg, range 93 to 375 µg/kg) in comparison to tolerance in the control puppies and despite the wide range of tolerance, each of the puppies with hypercapnic acidemia showed greater tolerance than its littermate control puppy. Assessment of the clinical implications of these findings will require study of the effects of alterations in acid-base balance on the inotropic effect of acetyl strophanthidin in addition to the toxic electrophysiologic effects.


1982 ◽  
Vol 63 (1) ◽  
pp. 56-56
Author(s):  
E. S. Karashurov ◽  
S. E. Karashurov

Frequent complications of glomectomy are headaches and a mild, less-like state for several days or weeks after surgery, and sometimes hemi- and monoparesis. The reasons for these complications have not yet been revealed. In search of their explanation, we decided to study the volumetric blood flow of the brain and the acid-base state (ACS). Volumetric blood flow was studied by rheoencephalography (REG) in 43 patients, and acid base balance - in 100 patients (age from 22 to 67 years). The course of bronchial asthma before the operation in the examined patients was moderate and severe.


Author(s):  
Isabel A. Lea ◽  
Susan J. Borghoff ◽  
Gregory S. Travlos

1989 ◽  
Vol 10 (04) ◽  
pp. 279-285 ◽  
Author(s):  
T. Yoshida ◽  
M. Udo ◽  
M. Chida ◽  
K. Makiguchi ◽  
M. Ichioka ◽  
...  

Toxicon ◽  
1982 ◽  
Vol 20 (4) ◽  
pp. 802-805 ◽  
Author(s):  
F. Tash ◽  
Kh. Ghoneim ◽  
N. Swelam ◽  
M.F. Bassiony ◽  
M.F. El-Asmar

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