Experimental production of gastric ulcers by vessel ligation

1968 ◽  
Vol 3 (4) ◽  
pp. 290-291
Author(s):  
T. Maki ◽  
T. Shiratori ◽  
M. Tsukamoto ◽  
N. Harata ◽  
T. Hatafuku ◽  
...  
Keyword(s):  
Gastric Ulcers ◽  
Experimental Production ◽  
Vessel Ligation

The experimental production of gastric ulcers by induced muscle spasm

1974 ◽  
Vol 61 (4) ◽  
pp. 259-263 ◽  
Author(s):  
George Qvist ◽  
John Dormandy ◽  
Colin Brown ◽  
David Slome ◽  
G. B. D. Scott
Keyword(s):  
Muscle Spasm ◽  
Gastric Ulcers ◽  
Experimental Production

scholarly journals THE EXPERIMENTAL PRODUCTION OF NECROSIS OF THE LIVER IN THE GUINEA PIG

1914 ◽  
Vol 20 (2) ◽  
pp. 169-179 ◽  
Author(s):  
Moyer S. Fleisher ◽  
Leo Loeb
Keyword(s):  
Guinea Pig ◽  
Intravenous Injection ◽  
Liver Cells ◽  
Gastric Ulcers ◽  
Toxic Substances ◽  
Experimental Production ◽  
Mechanical Factors

Through the intravenous injection of various substances differing very much in character, multiple necrosis can be produced in the liver of the guinea pig. In the mouse the effect of these substances is absent or much less marked. Different substances seem to differ, however, in their power to produce necrosis. In control animals necrosis in the liver is much more rare. It is found especially in animals subjected to various injurious influences. The necrotic areas are usually situated between the portal and central areas of the liver acini. Their development is not due to thromboses interfering with the circulation in certain areas of the liver. They are probably due to a weakening of the circulation in the liver or to interference with the metabolism of the cells as a result of the injection of foreign substances. Mechanical factors (pressure on the liver cells) may have an additional effect. This necrosis may be compared etiologically to the acute gastric ulcers which can be produced through a great variety of toxic substances in the guinea pig.

Gastric Ulcers Produced by Cisplatin

1981 ◽  
Vol 39 ◽  
pp. 582-583
Author(s):  
S.K. Aggarwal ◽  
J. San Antonio
Keyword(s):  
Electron Microscopy ◽  
Single Dose ◽  
Side Effects ◽  
Antitumor Agent ◽  
Gastric Ulcers ◽  
Enzyme Cytochemistry ◽  
Intestinal Toxicity ◽  
Ovarian Cancers ◽  
Inner Surface

Cisplatin (cis-dichlorodiammineplatinum(II)) a potent antitumor agent is now available for the treatment of testicular and ovarian cancers. It is however, not free from its serious side effects including nephrotoxicity, gastro intestinal toxicity, myelosuppression, and ototoxicity. Here we now report that the drug produces peculiar bloating of the stomach in rats and induces acute ulceration.Wistar-derived rats weighing 200-250 g were administered cisplatin(9 mg/kg) ip as a single dose in 0.15 M NaCl. After 3 days the animals were sacrificed by decapitation. The stomachs were removed, the contents analyzed for pepsin and acidity. The inner surface was examined with a dissecting microscope after a moderate stretching for ulcers. Affected areas were fixed and processed for routine electron microscopy and enzyme cytochemistry.The drug treated animals kept on food and water consistently showed bloating and lesions (Fig. 1) with a frequency of 6-70 ulcers in the rumen section of the stomachs.

Experimental production of human "blue velvet" and "red devil" lesions

JAMA ◽  
1966 ◽  
Vol 197 (13) ◽  
pp. 1100-1102 ◽  
Author(s):  
H. E. Puro
Keyword(s):  
Experimental Production
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