scholarly journals Antihyperglycemic effect of water extract of dry fruits ofTerminalia chebula in experimental diabetes mellitus

2004 ◽  
Vol 19 (2) ◽  
pp. 202-204 ◽  
Author(s):  
Y. K. Murali ◽  
Ramesh Chandra ◽  
P. S. Murthy
Keyword(s):  
Diabetes Mellitus ◽  
Experimental Diabetes ◽  
Water Extract ◽  
Experimental Diabetes Mellitus ◽  
Antihyperglycemic Effect ◽  
Effect Of Water

Antihyperglycemic effect of the fruit-pulp of Eugenia jambolana in experimental diabetes mellitus

2006 ◽  
Vol 104 (3) ◽  
pp. 367-373 ◽  
Author(s):  
Suman Bala Sharma ◽  
Afreena Nasir ◽  
Krishna Madhava Prabhu ◽  
Pothapragada Suryanarayana Murthy
Keyword(s):  
Diabetes Mellitus ◽  
Experimental Diabetes ◽  
Fruit Pulp ◽  
Experimental Diabetes Mellitus ◽  
Antihyperglycemic Effect ◽  
Eugenia Jambolana

scholarly journals Pathogenetical aspects of tubulointerstitial syndrome development in alloxan-induced experimental diabetes mellitus

2021 ◽  
Vol 25 (1) ◽  
pp. 17-21
Author(s):  
О. А. Olenovych
Keyword(s):  
Diabetes Mellitus ◽  
Filtration Rate ◽  
Experimental Diabetes ◽  
Intraperitoneal Administration ◽  
Water Extract ◽  
Male Rats ◽  
Control Group ◽  
Sodium Reabsorption ◽  
Experimental Diabetes Mellitus ◽  
Sodium And Potassium

Annotation. The aim of our study was to explore the pathogenetical aspects of tubulointerstitial syndrome development in alloxan-induced experimental diabetes mellitus. The experiments were carried out on 20 white non-linear mature male rats, 10 with experimental diabetes mellitus (EDМ) induced by intraperitoneal administration of alloxan at a dose of 160 mg/kg of body weight, 10 intact rats served as the control group. 25 days after administration of the diabetogenic substance, the animals were withdrawn from the experiment. The concentration of sodium and potassium ions in urine and blood plasma samples was determined, followed by calculation (considering water-induced 2-hour diuresis and endogenous creatinine clearance) of glomerular filtration rate, electrolyte excretion, their filtration rate, absolute and relative reabsorption, clearance, their proximal and distal renal transport. Removed after decapitation rats’ kidneys were dissected to 3 parts – renal cortex, medulla and papilla, sodium and potassium content was determined in water-extract of the corresponding part of the renal parenchyma, and papillary-cortical, papillary-medullar and medullary-cortical concentration ion gradients were calculated. Significant suppression of papillary-medullar and papillary-cortical concentration sodium gradients, as well as a slight limitation of its medullary-cortical gradient were established. The concentration potassium gradients were significantly reduced. Statistical processing of the obtained data was carried out with the determination of the average value, standard deviations. To assess the probability of the difference between the study groups used non-parametric Mann-Whitney ranking criterion according to the algorithms implemented in the computer program “Statistica for Windows”, “Version 8.0”. There was a decrease of the sodium-potassium ratio in urine, enhanced urinary excretion of potassium and an increase of its content in urine, as well as intensification of absolute transtubular sodium transport due to equivalent augmentation of the filtration charge of this cation, increase of proximal sodium reabsorption and, to a lesser degree, – of distal one. The distal and proximal sodium reabsorption, reduced to a unit of active nephrons, was found to be decreased, and the relative reabsorption of the cation significantly exceeded the control values, contributing to the limitation of natriuresis. The results of the study suggest that in 26-day alloxan-induced experimental diabetes hemodynamic-hyperperfusion overload on the tubular apparatus of the kidney causes the development of relative insufficiency of the proximal and distal tubules, disorders of hormone-dependent reabsorption of cations, limitation of regulatory influence of aldosterone and ADH with further tubulointerstitial disturbances that unable adequate osmotic concentration of urine.

Evoked Activity of Dorsal Root Afferent Fibers of the Rat Spinal Cord in Experimental Diabetes Mellitus

2016 ◽  
Vol 7 (2) ◽  
pp. 97-104
Author(s):  
Oleksandr G. Rodinsky ◽  
Elena G. Zinov'eva ◽  
Olexandr S. Trushenko ◽  
Maria J. Kachan
Keyword(s):  
Diabetes Mellitus ◽  
Spinal Cord ◽  
Dorsal Root ◽  
Experimental Diabetes ◽  
Rat Spinal Cord ◽  
Experimental Diabetes Mellitus ◽  
Afferent Fibers ◽  
Evoked Activity

Effect of Curcuma longa and Galega orientalis on renal function in rats with experimental diabetes mellitus and acute renal failure

2019 ◽  
pp. 88-95
Author(s):  
Р.И. Айзман ◽  
А.П. Козлова ◽  
Е.И. Гордеева ◽  
М.С. Головин ◽  
Г.А. Корощенко ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Renal Failure ◽  
Renal Function ◽  
Acute Renal Failure ◽  
Experimental Diabetes ◽  
Curcuma Longa ◽  
Diabetic Rats ◽  
Standard Diet ◽  
Experimental Diabetes Mellitus ◽  
Galega Orientalis

Цель - исследование влияния куркумы длинной и галеги восточной на осмо- и ионорегулирующую функции почек крыс при аллоксан-индуцированном сахарном диабете и острой почечной недостаточности в эксперименте. Методика. Эксперименты выполнены на самцах крыс Wistar (n=70) с моделью сахарного диабета (1-я серия) и острой почечной недостаточности (2-я серия). В обеих сериях животные были поделены на 3 группы: крыс 1-й группы содержали на стандартном корме, крысам остальных групп в корм добавляли куркуму (2-я группа) или галегу (3-я группа) (2% от массы корма). На 7-е сут эксперимента проводили исследование диуретической и ионоуретической функций почек натощак и после 5% водной нагрузки. Концентрацию ионов в моче и плазме определяли методом пламенной фотометрии; осмотическую концентрацию биологических жидкостей - методом криоскопии; биохимические показатели крови - колориметрическим методом. Результаты. У животных с сахарным диабетом фоновый диурез, а также экскреция натрия и калия были статистически значимо выше, чем у контрольных животных. При острой почечной недостаточности наблюдался более низкий уровень диуреза и ионоуреза, особенно после водной нагрузки. Прием куркумы и галеги вызывал улучшение осмо- и ионорегулирующей функции почек у крыс с сахарным диабетом, и практически не влиял на эти функции почек при острой почечной недостаточности. Заключение. При сахарном диабете оба фитопрепарата вызывали понижение концентрации глюкозы, креатинина, мочевины и улучшение ионно-осмотических показателей плазмы крови, при этом эффект куркумы был выражен отчетливее. При острой почечной недостаточности эти фитопрепараты не давали описанного эффекта. Aim. To study effects of the phytomedicines, Curcuma longa and Galega orientalis, on osmosis- and ion-regulating renal functions in rats with experimental diabetes mellitus (DM) and acute renal failure (ARF). Methods. Experiments were performed in two series on Wistar male rats (n=70) with modeled diabetes mellitus (series 1) and acute renal failure (series 2). In each series, the animals were divided into 3 groups, 1) rats of group 1 receiving a standard diet; 2) rats of groups 2 and 3 receiving a standard diet supplemented with turmeric or galega (2% of food weight), respectively. On the 7th day of the experiment, the diuretic and ionuretic renal function was studied in fasting state and after 5% water loading. Concentrations of ions in urine and plasma were determined by flame photometry; osmotic concentrations of biological fluids were measured by cryoscopy; blood biochemical parameters were measured by colorimetry. Results. In diabetic rats, background diuresis and sodium and potassium excretion were significantly higher than in the control animals. In rats with acute renal failure, diuresis and ionuresis were significantly lower, particularly after the water loading. Turmeric and galega supplementation improved the osmotic and ion-regulating renal function in diabetic rats and left practically unchanged these functions in rats with acute renal failure. Conclusion. In rats with diabetes mellitus, both herbal remedies reduced concentrations of glucose, creatinine, and urea and improved ion-osmotic parameters of blood plasma with a more pronounced effect of turmeric. In acute renal failure, these phytomedicines did not produce the described effects.

MORPHOFUNCTIONAL CHANGES IN THE LIVER OF 24-MONTH-OLD RATS IN THE EARLY STAGES OF EXPERIMENTAL DIABETES MELLITUS DEVELOPMENT

2018 ◽  
Vol 14 (65) ◽  
pp. 152
Author(s):  
O. Ya. Zhurakivska ◽  
Yu. V. Bodnarchuk ◽  
V. M. Pertsovych ◽  
H. B. Kulynych ◽  
V. A. Мiesoiedova
Keyword(s):  
Diabetes Mellitus ◽  
Experimental Diabetes ◽  
Experimental Diabetes Mellitus ◽  
Early Stages ◽  
Old Rats
Sign in / Sign up

Export Citation Format

Share Document