Neural cell adhesion molecule (NCAM) in normal and neoplastic human pituitary tissues: Analysis by immunohistochemistry and in situ hybridization

1992 ◽  
Vol 3 (3) ◽  
pp. 144-151 ◽  
Author(s):  
Long Jin ◽  
Michael Stone ◽  
William F. Chandler ◽  
Ricardo V. Lloyd
Keyword(s):  
Cell Adhesion ◽  
In Situ Hybridization ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Neural Cell ◽  
Human Pituitary ◽  
Neural Cell Adhesion

scholarly journals Differential expression of the neural cell adhesion molecule NCAM 140 in human pituitary tumors

FEBS Letters ◽  
1990 ◽  
Vol 272 (1-2) ◽  
pp. 45-49 ◽  
Author(s):  
Maria C. Aletsee-Ufrecht ◽  
Keith Langley ◽  
Otmar Gratzl ◽  
Manfred Gratzl
Keyword(s):  
Cell Adhesion ◽  
Differential Expression ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Pituitary Tumors ◽  
Neural Cell ◽  
Human Pituitary ◽  
Neural Cell Adhesion

Neural cell adhesion molecule expression in human pituitary adenomas

1995 ◽  
Vol 25 (3) ◽  
pp. 205-213 ◽  
Author(s):  
B. K. Kleinschmidt-DeMasters ◽  
David R. Conway ◽  
Wilbur A. Franklin ◽  
Kevin O. Lillehei ◽  
Carol A. Kruse
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Pituitary Adenomas ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Neural Cell ◽  
Adhesion Molecule Expression ◽  
Human Pituitary ◽  
Human Pituitary Adenomas ◽  
Neural Cell Adhesion

Expression of Neural Cell Adhesion Molecule and Polysialic Acid in Cultured Spiral Ganglion Neurons

Skull Base ◽  
2007 ◽  
Vol 17 (S 1) ◽  
Author(s):  
Kyoung Ho Park ◽  
Ki Hong Jang ◽  
Sang Yeo ◽  
Helge Rask-Andersen ◽  
Frederic Troy, II
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Polysialic Acid ◽  
Spiral Ganglion ◽  
Neural Cell ◽  
Spiral Ganglion Neurons ◽  
Neural Cell Adhesion ◽  
Ganglion Neurons

scholarly journals Regulation of Neural Cell Adhesion Molecule Polysialylation: Evidence for Nontranscriptional Control and Sensitivity to an Intracellular Pool of Calcium

1998 ◽  
Vol 140 (5) ◽  
pp. 1177-1186 ◽  
Author(s):  
Juan L. Brusés ◽  
Urs Rutishauser
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Calcium Ionophore ◽  
Cytosolic Calcium ◽  
Neural Cell ◽  
Ciliary Ganglion ◽  
Cellular Mechanisms ◽  
Neural Cell Adhesion

The up- and downregulation of polysialic acid–neural cell adhesion molecule (PSA–NCAM) expression on motorneurons during development is associated respectively with target innervation and synaptogenesis, and is regulated at the level of PSA enzymatic biosynthesis involving specific polysialyltransferase activity. The purpose of this study has been to describe the cellular mechanisms by which that regulation might occur. It has been found that developmental regulation of PSA synthesis by ciliary ganglion motorneurons is not reflected in the levels of polysialyltransferase-1 (PST) or sialyltransferase-X (STX) mRNA. On the other hand, PSA synthesis in both the ciliary ganglion and the developing tectum appears to be coupled to the concentration of calcium in intracellular compartments. This study documents a calcium dependence of polysialyltransferase activity in a cell-free assay over the range of 0.1–1 mM, and a rapid sensitivity of new PSA synthesis, as measured in a pulse–chase analysis of tissue explants, to calcium ionophore perturbation of intracellular calcium levels. Moreover, the relevant calcium pool appears to be within a specific intracellular compartment that is sensitive to thapsigargin and does not directly reflect the level of cytosolic calcium. Perturbation of other major second messenger systems, such as cAMP and protein kinase–dependent pathways, did not affect polysialylation in the pulse chase analysis. These results suggest that the shuttling of calcium to different pools within the cell can result in the rapid regulation of PSA synthesis in developing tissues.

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