scholarly journals Rescue therapy with inhaled nitric oxide in critically ill patients with severe hypoxemic respiratory failure (Brief report)

2002 ◽  
Vol 49 (3) ◽  
pp. 315-318 ◽  
Author(s):  
Fred J. Baxter ◽  
Jill Randall ◽  
John D. Miller ◽  
David A. Higgins ◽  
A. C. Peter Powles ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Respiratory Failure ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Rescue Therapy ◽  
Inhaled Nitric Oxide ◽  
Hypoxemic Respiratory Failure

Inhaled Nitric Oxide Treatment for Stabilization and Emergency Medical Transport of Critically Ill Newborns and Infants

PEDIATRICS ◽  
1995 ◽  
Vol 95 (5) ◽  
pp. 773-776
Author(s):  
John P. Kinsella ◽  
Jeffrey M. Schmidt ◽  
Jeff Griebel ◽  
Steven H. Abman
Keyword(s):  
Nitric Oxide ◽  
Respiratory Failure ◽  
Critically Ill ◽  
Tertiary Care ◽  
Inhaled Nitric Oxide ◽  
Hypoxemic Respiratory Failure ◽  
Emergency Medical ◽  
Medical Transport ◽  
Tertiary Care Centers ◽  
Inhaled No

Stabilization and transport of critically ill newborns and infants is a vital component of regionalized care. With the advent and proliferation of new therapies for the management of severe hypoxemic respiratory failure, emergency medical transport to tertiary care centers increasingly requires novel transport innovations. Inhaled nitric oxide (NO) therapy has been used in the management of severe persistent pulmonary hypertension of newborns (PPHN) and of hypoxemic respiratory failure in older pediatric patients.1-5 We report the use of inhaled NO therapy during transport in six patients with critical hypoxemia. This report describes a practical approach to stabilization and transport of critically ill newborns and infants using inhaled NO.

Soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1) is Highly Associated With Mortality and Persistent Organ Dysfunction in the Critically Ill: a Cohort Study

2020 ◽  
Author(s):  
Neha Alhad Sathe ◽  
Pavan K. Bhatraju ◽  
Carmen Mikacenic ◽  
Eric D. Morrell ◽  
W. Conrad Liles ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Respiratory Failure ◽  
Critically Ill ◽  
Organ Dysfunction ◽  
Critically Ill Patients ◽  
Academic Medical Center ◽  
Myeloid Cells ◽  
Soluble Form ◽  
Hypoxemic Respiratory Failure ◽  
Study Enrollment

Abstract Background. The triggering receptor expressed on myeloid cells-1 (TREM-1) mediates fatal septic shock in murine models, but studies linking the soluble form of TREM-1 (sTREM-1) to mortality in clinical sepsis are inconclusive, and few have examined its relationship to organ dysfunction. We sought to identify associations between circulating sTREM-1 and both mortality and organ dysfunction among a broad cohort of critically ill medical, post-surgical and trauma patients. Methods. We enrolled a prospective cohort of patients who met two or more criteria for the systemic inflammatory response syndrome (SIRS) within 24 hours of intensive care unit (ICU) admission at a large academic medical center. sTREM-1 concentrations were measured at study enrollment. We used relative risk regression, adjusted for age, sex, and Charlson comorbidity index, to determine associations between sTREM-1 and the primary outcome of 28-day mortality. We also examined secondary outcomes of prevalent organ dysfunction on enrollment, and composites of persistent organ dysfunction or death at day 7. Results. Among 231 critically ill patients, non-survivors (n=19, 8%) had a higher proportion of pre-existing comorbidities, mechanical ventilation (79% vs. 44%) and shock (58% vs. 28%) compared to survivors. At study enrollment, increasing sTREM-1 was associated with a higher risk of severe acute kidney injury (AKI), shock, and acute hypoxemic respiratory failure requiring mechanical ventilation. sTREM-1 was higher among non-survivors than survivors (885 vs 336 pg/mL); each doubling of sTREM-1 concentration was associated with a 2.41-fold higher risk of 28-day mortality (95% CI 1.57, 3.72). Among 92 patients with shock on enrollment, doubling of sTREM-1 was associated with a 3.89-fold higher risk of persistent shock or death by day 7 (95% CI 1.85, 8.17). Higher sTREM-1 was also associated with a higher risk of both persistent AKI and persistent hypoxemic respiratory failure or death. Conclusions. Elevated plasma sTREM-1 is highly associated with 28-day mortality and organ dysfunction across a diverse critically ill population. These data support that early activation of the innate immune system plays a role in the development of organ dysfunction and death. Further studies should address whether modulation of the TREM-1 pathway might be beneficial in critically ill patients.

scholarly journals Inhaled Nitric Oxide Use in Pediatric Hypoxemic Respiratory Failure

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
John T. Berger ◽  
Aline B. Maddux ◽  
Ron W. Reeder ◽  
Russell Banks ◽  
Peter M. Mourani ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Respiratory Failure ◽  
Inhaled Nitric Oxide ◽  
Hypoxemic Respiratory Failure

Inhaled epoprostenol vs inhaled nitric oxide for refractory hypoxemia in critically ill patients

2013 ◽  
Vol 28 (5) ◽  
pp. 844-848 ◽  
Author(s):  
Heather Torbic ◽  
Paul M. Szumita ◽  
Kevin E. Anger ◽  
Paul Nuccio ◽  
Susan LaGambina ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Inhaled Nitric Oxide ◽  
Refractory Hypoxemia

scholarly journals Longitudinal follow-up in Preterm and Full Term Newborns Treated with Inhaled Nitric Oxide (iNO) for Severely Hypoxemic Respiratory Failure

1999 ◽  
Vol 45 (4, Part 2 of 2) ◽  
pp. 211A-211A
Author(s):  
Jean-Christophe Mercier ◽  
Peter Onody ◽  
Patrick Truffert ◽  
Josefa Llado-Paris ◽  
Anne Clerckx
Keyword(s):  
Nitric Oxide ◽  
Respiratory Failure ◽  
Full Term ◽  
Inhaled Nitric Oxide ◽  
Hypoxemic Respiratory Failure ◽  
Term Newborns

Is there a role for inhaled nitric oxide as a rescue therapy in respiratory failure associated with hematologic malignancies?

2006 ◽  
Vol 81 (10) ◽  
pp. 729-734
Author(s):  
Mark T. Keegan ◽  
Eric Nygren ◽  
Bekele Afessa ◽  
William J. Hogan ◽  
Barry A. Harrison
Keyword(s):  
Nitric Oxide ◽  
Respiratory Failure ◽  
Rescue Therapy ◽  
Hematologic Malignancies ◽  
Inhaled Nitric Oxide

scholarly journals INHALED NITRIC OXIDE IN COVID-19-INDUCED HYPOXEMIC RESPIRATORY FAILURE

CHEST Journal ◽  
2021 ◽  
Vol 160 (4) ◽  
pp. A1125-A1126
Author(s):  
Siva Naga Yarrarapu ◽  
Abhishek Giri ◽  
Israr Baloch ◽  
Nirmaljot Kaur ◽  
Augustine Lee ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Respiratory Failure ◽  
Inhaled Nitric Oxide ◽  
Hypoxemic Respiratory Failure
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