Genes associated with long-chain omega-3 fatty acids in bovine skeletal muscle

2010 ◽  
Vol 51 (4) ◽  
pp. 479-487 ◽  
Author(s):  
R. Perez ◽  
J. Cañón ◽  
S. Dunner
1994 ◽  
Vol 299 (3) ◽  
pp. 831-837 ◽  
Author(s):  
S Liu ◽  
V E Baracos ◽  
H A Quinney ◽  
M T Clandinin

Feeding animals with diets high in saturated fat induces insulin resistance, and replacing saturated fat isocalorically with poly-unsaturated fat, especially long-chain omega-3 fatty acids, will prevent the development of insulin resistance in skeletal-muscle tissue. To investigate the mechanism, rats were fed on high-fat (20%, w/w) semipurified diets for 6 weeks. Diets containing ratios of polyunsaturated/saturated (P/S) fatty acid of 0.25 (low-P/S diet) and 1.0 (high-P/S diet) were used to study the effect of the level of saturated fat. To study the effects of omega-3 fatty acids, diets with a low-P/S ratio containing either 0 (low-omega-3 diet) or 3.3% (high-omega-3 diet) long-chain omega-3 fatty acids from fish oil were fed. Plasma membrane from skeletal muscle was purified. The content of fatty acids in sarcolemmal phospholipid was significantly related to the dietary composition. Insulin binding to intact sarcolemmal vesicles prepared from rats fed on diets high in omega-3 fatty acids increased 14-fold compared with animals fed on the low-omega-3 diet (P < 0.0001). Feeding rats on a diet with a high P/S ratio increased sarcolemmal insulin binding by 2.3-fold (P < 0.05). Increased insulin binding was due to increased receptor number at the low-affinity high-capacity binding site. Dietary effects on insulin binding were eliminated when studies were carried out on detergent-solubilized membranes, indicating the importance of the phospholipid fatty acyl composition for insulin binding. The results suggest that dietary omega-3 and polyunsaturated fatty acids increase insulin binding to sarcolemma by changing the fatty acyl composition of phospholipid surrounding the insulin receptor, and this might be the mechanism by which dietary fatty acids modify insulin action.


Foods ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1816
Author(s):  
Michael F. Tlusty

Humans under-consume fish, especially species high in long-chain omega-3 fatty acids. Food-based dietary guidelines are one means for nations to encourage the consumption of healthy, nutritious food. Here, associations between dietary omega-3 consumption and food-based dietary guidelines, gross domestic product, the ranked price of fish, and the proportions of marine fish available at a national level were assessed. Minor associations were found between consumption and variables, except for food-based dietary guidelines, where calling out seafood in FBDGs did not associate with greater consumption. This relationship was explored for consumers in the United States, and it was observed that the predominant seafood they ate, shrimp, resulted in little benefit for dietary omega-3 consumption. Seafood is listed under the protein category in the U.S. Dietary Guidelines, and aggregating seafood under this category may limit a more complete understanding of its nutrient benefits beyond protein.


2021 ◽  
Vol 4 ◽  
pp. 100089
Author(s):  
Rachel A Murphy ◽  
Prasad P. Devarshi ◽  
Shauna Ekimura ◽  
Keri Marshall ◽  
Susan Hazels Mitmesser

2009 ◽  
Vol 41 (1) ◽  
pp. 36-66 ◽  
Author(s):  
Lefkothea-Stella Kremmyda ◽  
Maria Vlachava ◽  
Paul S. Noakes ◽  
Norma D. Diaper ◽  
Elizabeth A. Miles ◽  
...  

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