scholarly journals 10.4 Acute Administration of Vitamin C Decreases Sympathetic Nervous Activity and Blood Pressure in Hypertensive Patients

2008 ◽  
Vol 15 (3) ◽  
pp. 293-293
Author(s):  
R.M. Bruno ◽  
E. Daghini ◽  
L. Ghiadoni ◽  
I. Sudano ◽  
D. Versari ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Vitamin C ◽  
Nervous Activity ◽  
Sympathetic Nervous Activity ◽  
Acute Administration ◽  
Hypertensive Patients ◽  
Sympathetic Nervous

scholarly journals Effect of propranolol on sympathetic nervous activity in hydrallazine- treated hypertensive patients.

1978 ◽  
Vol 6 (3) ◽  
pp. 217-220 ◽  
Author(s):  
M Velasco ◽  
E Romero ◽  
H Bertoncini ◽  
A Urbina-Quintana ◽  
J Guevara ◽  
...  
Keyword(s):  
Nervous Activity ◽  
Sympathetic Nervous Activity ◽  
Hypertensive Patients ◽  
Sympathetic Nervous

Effects of long term device-guided slow breathing on sympathetic nervous activity in hypertensive patients: a randomized open-label clinical trial

2017 ◽  
Vol 26 (6) ◽  
pp. 359-365 ◽  
Author(s):  
Silvana de Barros ◽  
Giovanio Vieira da Silva ◽  
Josiane Lima de Gusmão ◽  
Tatiana Goveia de Araújo ◽  
Dinoélia Rosa de Souza ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Nervous Activity ◽  
Sympathetic Nervous Activity ◽  
Open Label ◽  
Hypertensive Patients ◽  
Sympathetic Nervous ◽  
Slow Breathing

scholarly journals 10.3 Inhibition of NO-Synthase Modulates Sympathetic Nervous Activity in hypertensive Patients

2008 ◽  
Vol 15 (3) ◽  
pp. 292-292
Author(s):  
R.M. Bruno ◽  
I. Sudano ◽  
L. Ghiadoni ◽  
A. Magagna ◽  
S. Taddei ◽  
...  
Keyword(s):  
Nervous Activity ◽  
No Synthase ◽  
Sympathetic Nervous Activity ◽  
Hypertensive Patients ◽  
Sympathetic Nervous

Abstract 5430: Obstructive Sleep Apnoea Exacerbates Muscular Sympathetic Nervous Activity in Patients with Metabolic Syndrome

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Ivani C Trombetta ◽  
Cristiane M Nunes ◽  
Luciano F Drager ◽  
Raffael F Fraga ◽  
Maria Janieire N Alves ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Heart Rate ◽  
Oxygen Saturation ◽  
Obstructive Sleep Apnoea ◽  
Nervous Activity ◽  
Sleep Apnoea ◽  
Sympathetic Nervous Activity ◽  
Obstructive Sleep ◽  
Sympathetic Nervous

Obstructive sleep apnoea (OSA) and metabolic syndrome (MetS) independently increases muscular sympathetic nervous activity (MSNA). Unknown is whether OSA has an additive effect on MSNA in patients with MetS. We tested the hypothesis that: OSA would have an additive effect on MSNA in patients with MetS. In addition, we studied whether the increase in MSNA in patients with MetS is associated with alteration in arterial baroreflex sensitivity (BRS). Twenty four patients with MetS diagnosed according ATP-III were divided in two groups: MetS+OSA (n=14) and MetS (n=10). They were matched for age, body mass index, waist circumference, and metabolic profile: OSA was defined by an apnoea/hypopnoea index (AHI)>15 events/hour by polysonography. MSNA was recorded directly from the peroneal nerve using the technique of microneurography. Blood pressure (BP) was monitored on a beat-by-beat basis (Finapress) and heart rate by ECG. BRS was analyzed by spontaneous BP and heart rate fluctuations. AHI was higher (42±9 vs. 7±1 events/h, P =0.0001) and minimum oxygen saturation lower (77±2 vs. 87±1 %, P =0.001) in MetS+OSA patients. Patients MetS+OSA had higher MSNA (55±3 vs. 43±2 bursts/100 beats, P =0.01) and systolic BP (158±4 vs.144±3 mmHg, P =0.01) when compared with patients with MetS without OSA. Further analysis showed that AHI and minimum oxygen saturation have significant correlation with MSNA (r=0.65; P =0.001 and r=−0.48; P =0.017, respectively). Patients with MetS+OSA had lower BRS for increases (7.8±0.9 vs. 13.4 ± 1.4 msec/mmHg, P =0.01) and decreases (7.2±0.9 vs. 13.2 ± 2.0 msec/mmHg, P =0.03) in blood pressure than patients with MetS without OSA. MSNA significantly correlated with BRS during spontaneous increases in blood pressure (r=−0.56, P =0.01). OSA exacerbates MSNA in patients with MetS. In addition, the augmented MSNA in patients with MetS+OSA is associated with reduced BRS. These findings suggest that OSA increases the risk for cardiovascular disease in patients with MetS.

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