Clinically important drug interactions

Reactions ◽  
1988 ◽  
Vol 215 (1) ◽  
pp. 3-4
Keyword(s):  
Drug Interactions ◽  
Important Drug

scholarly journals In Silico Prediction of Drug–Drug Interactions Mediated by Cytochrome P450 Isoforms

Pharmaceutics ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 538
Author(s):  
Alexander V. Dmitriev ◽  
Anastassia V. Rudik ◽  
Dmitry A. Karasev ◽  
Pavel V. Pogodin ◽  
Alexey A. Lagunin ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Interactions ◽  
Cytochromes P450 ◽  
Investigational Drug ◽  
Web Resource ◽  
Average Accuracy ◽  
Structural Formulas ◽  
Cytochrome P450 Isoforms ◽  
Leave One Out ◽  
Important Drug

Drug–drug interactions (DDIs) can cause drug toxicities, reduced pharmacological effects, and adverse drug reactions. Studies aiming to determine the possible DDIs for an investigational drug are part of the drug discovery and development process and include an assessment of the DDIs potential mediated by inhibition or induction of the most important drug-metabolizing cytochrome P450 isoforms. Our study was dedicated to creating a computer model for prediction of the DDIs mediated by the seven most important P450 cytochromes: CYP1A2, CYP2B6, CYP2C19, CYP2C8, CYP2C9, CYP2D6, and CYP3A4. For the creation of structure–activity relationship (SAR) models that predict metabolism-mediated DDIs for pairs of molecules, we applied the Prediction of Activity Spectra for Substances (PASS) software and Pairs of Substances Multilevel Neighborhoods of Atoms (PoSMNA) descriptors calculated based on structural formulas. About 2500 records on DDIs mediated by these cytochromes were used as a training set. Prediction can be carried out both for known drugs and for new, not-yet-synthesized substances. The average accuracy of the prediction of DDIs mediated by various isoforms of cytochrome P450 estimated by leave-one-out cross-validation (LOO CV) procedures was about 0.92. The SAR models created are publicly available as a web resource and provide predictions of DDIs mediated by the most important cytochromes P450.

Principles of Clinically Important Drug Interactions with Carbamazepine. Part II

1991 ◽  
Vol 11 (5) ◽  
pp. 306???312
Author(s):  
TERENCE A. KETTER ◽  
ROBERT M. POST ◽  
KATHY WORTHINGTON
Keyword(s):  
Drug Interactions ◽  
Important Drug

Important Drug Interactions in Dermatology

Drugs ◽  
2000 ◽  
Vol 59 (2) ◽  
pp. 181-192 ◽  
Author(s):  
Thomas Christian Roos ◽  
Hans Friedrich Merk
Keyword(s):  
Drug Interactions ◽  
Important Drug

Appropriate Prescribing and Important Drug Interactions in Older Adults

2015 ◽  
Vol 99 (2) ◽  
pp. 295-310 ◽  
Author(s):  
Jeffrey Wallace ◽  
Douglas S. Paauw
Keyword(s):  
Older Adults ◽  
Drug Interactions ◽  
Appropriate Prescribing ◽  
Important Drug

scholarly journals Practical Pointers: Clinically important drug-drug interactions and how to manage them*

2009 ◽  
Vol 1 (2) ◽  
pp. 150 ◽  
Author(s):  
Linda Bryant ◽  
Tana Fishman
Keyword(s):  
Health Care ◽  
Primary Health Care ◽  
Drug Interactions ◽  
Primary Health ◽  
Important Drug

* This article is designed to be read in conjunction with the A3 table of drug interactions provided as an insert in this issue of the Journal of Primary Health Care and also available on the journal website.

Important drug interactions exist between cannabidiol oil and commonly prescribed drugs in rheumatology practice

Rheumatology ◽  
2019 ◽  
Vol 59 (1) ◽  
pp. 249-251 ◽  
Author(s):  
Harold Wilson-Morkeh ◽  
Ahmad Al-Abdulla ◽  
Lauren Sien ◽  
Hodan Mohamed ◽  
Taryn Youngstein
Keyword(s):  
Drug Interactions ◽  
Important Drug ◽  
Rheumatology Practice
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