Association of the peroxisome proliferator-activated receptor-γ2 Pro12Ala but not the C1431T gene variants with lower body mass index in Type 2 diabetes

2007 ◽  
Vol 30 (11) ◽  
pp. 937-943 ◽  
Author(s):  
M. Ben Hadj Mohamed ◽  
N. Mtiraoui ◽  
I. Ezzidi ◽  
M. Chaieb ◽  
T. Mahjoub ◽  
...  

2000 ◽  
Vol 66 (2) ◽  
pp. 527-538 ◽  
Author(s):  
Robert C. Williams ◽  
Jeffrey C. Long ◽  
Robert L. Hanson ◽  
Maurice L. Sievers ◽  
William C. Knowler


2020 ◽  
Vol 27 (15) ◽  
pp. 1649-1660
Author(s):  
Sofia Perez-Calahorra ◽  
Fernando Civeira ◽  
Pilar Guallar-Castillón ◽  
Xavier Pinto ◽  
José R Banegas ◽  
...  

A low prevalence of type 2 diabetes mellitus has been reported in familial hypercholesterolaemia. Whether a healthier lifestyle could explain it has not been explored. This cross-sectional study determines the prevalence of lifestyle-related cardiovascular risk factors in heterozygous familial hypercholesterolaemia (HeFH) from the Dyslipidaemia Registry of the Spanish Atherosclerosis Society and in the ENRICA study, a representative sample of the adult Spanish general population, weighted to match the age and sex distribution of the HeFH sample. A total of 2185 HeFH patients and 11,856 individuals from ENRICA were included. HeFH had lower body mass index and fewer of them were smokers than in the reference population. A model adjusted for age, sex and body mass index showed that HeFH more frequently had cardiovascular disease (odds ratio (OR) 23.98; 95% confidence interval (CI) 18.40–31.23) and hypertension (OR 1.20; 95% CI 1.07–1.35), and took anti-hypertensive medication (OR 1.36; 95% CI 1.18–1.56) and anti-diabetic medication (OR 1.25; 95% CI 1.00–1.56), but less frequently were smokers (OR 0.79; 95% CI 0.71–0.89). In a HeFH subsample ( n = 513) with complete blood glucose information, those patients without cardiovascular disease showed lower prevalence of smoking and type 2 diabetes mellitus, lower body mass index and glucose, and higher diastolic blood pressure than the Spanish population. The differences in type 2 diabetes mellitus were justified mostly by the difference in body mass index. Body mass index adjustment also showed higher prevalence of hypertension and use of anti-hypertensive drugs in HeFH. In summary, HeFH patients had lower body mass index, which may contribute to explaining the lower prevalence of diabetes, and lower current smoking but higher hypertension.



Oncotarget ◽  
2017 ◽  
Vol 8 (42) ◽  
pp. 73133-73143 ◽  
Author(s):  
Jian Wang ◽  
Rengna Yan ◽  
Juan Wen ◽  
Xiaocen Kong ◽  
Huiqin Li ◽  
...  


2020 ◽  
Vol 39 (1) ◽  
pp. 192-197 ◽  
Author(s):  
Linlin Li ◽  
Jinjin Wang ◽  
Zhiguang Ping ◽  
Yuqian Li ◽  
Chongjian Wang ◽  
...  


Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 2496-PUB
Author(s):  
ZHANG CHENGHUI ◽  
LI MINGXIA ◽  
WANG SUYUAN ◽  
WU YUNHONG


Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 2086-P
Author(s):  
ERIC NYLEN ◽  
PETER KOKKINOS ◽  
CHARLES FASELIS ◽  
PUNEET NARAYAN ◽  
PAMELA KARASIK ◽  
...  


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