Effects of Amobarbital on the Conditioned Emotional Response and Conditioned Avoidance Response

1966 ◽  
Vol 16 (1) ◽  
pp. 13-16 ◽  
Author(s):  
Dennis K. Kamano ◽  
Louis K. Martin ◽  
Michael E. Ogle ◽  
Barbara J. Powell
1966 ◽  
Vol 18 (2) ◽  
pp. 645-646 ◽  
Author(s):  
Barbara J. Powell ◽  
M. E. Ogle ◽  
L. K. Martin ◽  
D. K. Kamano

In studying the relationship between level of CS intensity (light) and drug condition (amobarbital sodium) in the acquisition of the conditioned avoidance response of the white rat in a jump-box task, data showed that both variables influenced avoidance performance. Although the over-all performance of drugged Ss was better than that of those given a placebo, primary differences occurred at 50,000 and 800,000 peak candles of CS intensity; performance of Ss under placebo showed a marked decline at 800,000 peak candles.


1976 ◽  
Vol 25 (3) ◽  
pp. 448-448
Author(s):  
R. DANTZER ◽  
P. MORMEDE ◽  
B. FAVRE

Author(s):  
Amit S. Kamdi ◽  
Sarika D. Kokane ◽  
Pankaj N. Bohra ◽  
Suvarna M. Kalambe

Background: Schizophrenia is one of the most distressing central nervous system (CNS) disorders. It is described by positive, negative and cognitive symptoms. These symptoms can be controlled by the antipsychotic medicines. The numerous antipsychotic medications used today are not lacking the adverse drug reactions. The Withania coagulans a susceptible species, is not explored much for its CNS effects except in late seventies. Therefore, it was thought worthwhile to investigate anti-psychotic activities of alcoholic extract of Withania coagulans fruits. The objective of the present study was to assess the antipsychotic activity of alcoholic extract of Withania coagulans fruits in Swiss albino mice by Cook’s Pole Climb Apparatus for conditioned avoidance response (CAR)Methods: Cook’s Pole Climb Apparatus for conditioned avoidance response was used for assessing the antipsychotic activity of the alcoholic extract of 200mg/kg, 500mg/kg and 1000mg/kg doses of Withania coagulans fruits.Results: There was statistically (p-value >0.05) no significant association between any of the 200mg/kg, 500mg/kg and 1000mg/kg doses of the alcoholic extracts of Withania coagulans fruits with antipsychotic activity in Swiss albino mice.Conclusions: Withania coagulans fruits alcoholic extract did not demonstrate antipsychotic activity in Swiss albino mice under standard conditions.


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