scholarly journals The antipsychotic activity of alcoholic extract of Withania coagulans fruits in Swiss albino mice

2018 ◽  
Vol 7 (12) ◽  
pp. 2389
Author(s):  
Amit S. Kamdi ◽  
Sarika D. Kokane ◽  
Pankaj N. Bohra ◽  
Suvarna M. Kalambe
Keyword(s):  
Avoidance Response ◽  
Conditioned Avoidance ◽  
Conditioned Avoidance Response ◽  
P Value ◽  
Alcoholic Extract ◽  
Swiss Albino Mice ◽  
Withania Coagulans ◽  
Antipsychotic Activity ◽  
Albino Mice ◽  
Cns Effects

Background: Schizophrenia is one of the most distressing central nervous system (CNS) disorders. It is described by positive, negative and cognitive symptoms. These symptoms can be controlled by the antipsychotic medicines. The numerous antipsychotic medications used today are not lacking the adverse drug reactions. The Withania coagulans a susceptible species, is not explored much for its CNS effects except in late seventies. Therefore, it was thought worthwhile to investigate anti-psychotic activities of alcoholic extract of Withania coagulans fruits. The objective of the present study was to assess the antipsychotic activity of alcoholic extract of Withania coagulans fruits in Swiss albino mice by Cook’s Pole Climb Apparatus for conditioned avoidance response (CAR)Methods: Cook’s Pole Climb Apparatus for conditioned avoidance response was used for assessing the antipsychotic activity of the alcoholic extract of 200mg/kg, 500mg/kg and 1000mg/kg doses of Withania coagulans fruits.Results: There was statistically (p-value >0.05) no significant association between any of the 200mg/kg, 500mg/kg and 1000mg/kg doses of the alcoholic extracts of Withania coagulans fruits with antipsychotic activity in Swiss albino mice.Conclusions: Withania coagulans fruits alcoholic extract did not demonstrate antipsychotic activity in Swiss albino mice under standard conditions.

scholarly journals The antianxiety activity of aqueous extract of Withania coagulans fruits in swiss albino mice by elevated plus maze

2020 ◽  
Vol 9 (9) ◽  
pp. 1337
Author(s):  
Devesh D. Gosavi ◽  
Amit S. Kamdi ◽  
Suvarna M. Kalambe ◽  
Pankaj N. Bohra
Keyword(s):  
Aqueous Extract ◽  
Open Space ◽  
Elevated Plus Maze ◽  
P Value ◽  
Swiss Albino Mice ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Withania Coagulans ◽  
Plus Maze ◽  
Albino Mice

Background: Several anti-anxiety drugs used today have the numerous side effects. The Withania coagulans a rare species, is not studied much for its actions on anxiety except in late seventies where it was explored for neuropsychopharmacology. Thus, it was thought commendable to explore the anti-anxiety activities of aqueous extract of Withania coagulans fruits in swiss albino mice using elevated plus maze test.Methods: Elevated plus maze (EPM) test was used for evaluating the anti-anxiety action of Withania coagulans fruits’ aqueous extract. If the extract had anti-anxiety action, then it was expected that the time spent in the open space would increase and that in the closed space would decrease. This increase in time in the open space, if found statistically significant, was considered for antianxiety action.Results: There was statistically highly significant (p value <0.001) association observed between the aqueous extract of Withania coagulans fruits with antianxiety action in the swiss albino mice by elevated plus maze test.Conclusions: The aqueous extract of Withania coagulans fruits did prove the antianxiety effect in the swiss albino mice by elevated plus maze test.

scholarly journals The Motor Coordination Activity Of Aqueous Extract Of Withania Coagulans Fruits In Swiss Albino Mice By Rota Rod Test

2020 ◽  
Vol 2 (3) ◽  
Author(s):  
Amit Shankarrao Kamdi ◽  
Devesh D. Gosavi ◽  
Suvarna M. Kalambe ◽  
Pankaj N. Bohra
Keyword(s):  
Aqueous Extract ◽  
Motor Coordination ◽  
P Value ◽  
Endurance Time ◽  
Swiss Albino Mice ◽  
Cns Depressant ◽  
Withania Coagulans ◽  
Rota Rod Test ◽  
Albino Mice ◽  
Cns Depressant Activity

Background: The various sedative and hypnotic medications used today have the central nervous system (CNS) depressant effects. A very little work has been done on the Withania coagulans – a vulnerable species as it is not found rampant in the world except in late seventies. Therefore, it was important to explore the CNS depressant activities of aqueous extract of Withania coagulans fruits in Swiss albino mice by using rota rod test. Methods: Motor coordination was assessed by using the Rota Rod Test. The CNS depressant drugs decrease the endurance time of mice on the rota rod as they impair the motor coordination so that mice fall early on the rotating rod. This endurance time is statistically correlated among the control, standard and the test drugs. Results: There was statistically highly significant (p-value < 0.001) association observed between aqueous extract of Withania coagulans fruits with endurance time in Swiss albino mice on rota rod test. Conclusion: The aqueous extract of Withania coagulans fruits demonstrated the CNS depressant activity in Swiss albino mice by rota rod test.

scholarly journals The spontaneous motor activity of aqueous extract of Withania coagulans fruits in Swiss albino mice by actophotometer

2020 ◽  
Vol 9 (9) ◽  
pp. 1440
Author(s):  
Devesh D. Gosavi ◽  
Amit S. Kamdi ◽  
Suvarna M. Kalambe ◽  
Pankaj N. Bohra
Keyword(s):  
Locomotor Activity ◽  
Aqueous Extract ◽  
Motor Coordination ◽  
Spontaneous Locomotor Activity ◽  
P Value ◽  
Swiss Albino Mice ◽  
Cns Depressant ◽  
Withania Coagulans ◽  
Albino Mice ◽  
Cns Depressant Activity

Background: People spend about one third of their time in sleep every day. The various sedative and hypnotic medications used today have numerous side effects. In the late seventies a very little work was done on the Withania coagulans - a vulnerable species that is found scattered in the world. Therefore, it was essential to discover the CNS depressant activities of aqueous extract of Withania coagulans fruits in swiss albino mice by using actophotometer.Methods: The spontaneous locomotor activity was evaluated by using the actophotometer. The CNS depressant drugs decrease the locomotor activity in mice as they impair the motor coordination so that mice stay at one place for the longer time. Therefore, there is less disruption of the beams of light. This spontaneous locomotor activity time is statistically correlated among the control, standard and the test drugs.Results: There was statistically highly significant (p value <0.001) association observed between aqueous extract of Withania coagulans fruits with spontaneous locomotor activity in swiss albino mice on the actophotometer.Conclusions: The aqueous extract of Withania coagulans fruits demonstrated the CNS depressant activity in swiss albino mice by actophotometer.

scholarly journals The study of effects of inhibition of the renin angiotensin system on memory in rats

2018 ◽  
Vol 7 (9) ◽  
pp. 1847
Author(s):  
Medhinee Kulkarni ◽  
Prasad Pandit ◽  
Kiran Bhave
Keyword(s):  
Avoidance Response ◽  
Normal Saline ◽  
Renin Angiotensin System ◽  
Conditioned Avoidance ◽  
Study Groups ◽  
Conditioned Avoidance Response ◽  
P Value ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Significant Difference

Background: The existence of an independent renin angiotensin aldosterone system (RAAS) has been well-established and is known to modulate various pathological processes such as neuroinflammation, neurodegeneration, and neural injury, in addition to the RAAS in the cardiovascular system.Methods: Eighteen Wistar rats were divided into 3 study groups (n=6; Losartan, Ramipril, Normal Saline), trained on the Cook’s Pole climbing apparatus till the conditioned avoidance response (CAR) rate was 100%. The retention of CAR was tested each week for 4 consecutive weeks. The number of times that the animal successfully avoided the shock, and the time taken for this avoidance were measured and compared with placebo (Normal Saline). The values have been expressed as Mean±Standard Deviation (SD). A p-value of less than 0.05 has been considered as significant.Results: The retention of the conditioned avoidance response in the group receiving study drugs was significantly more than the placebo group. However, there was no show significant difference between Losartan and Ramipril in the rate of retention, or the time taken for avoidance.Conclusions: In this study, Ramipril and Losartan have a beneficial effect on learning and memory as compared to plcebo.

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